Volume 34, Issue 4 (June 2026)
JSSU 2026, 34(4): 10094-10112 |
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balalak R, Ebrahimi M, Amirchaghmaghi E. Role of Natural Killer (NK) Cells in Endometriosis. JSSU 2026; 34 (4) :10094-10112
URL: http://jssu.ssu.ac.ir/article-1-6469-en.html
URL: http://jssu.ssu.ac.ir/article-1-6469-en.html
Abstract: (22 Views)
Introduction: Endometriosis is a chronic inflammatory disorder that depends on estrogen and affects approximately 10% of women of reproductive age. Although the exact cause of endometriosis remains unclear, it is suggested that combination of genetic, hormonal, and immunological factors is involved in its pathogenesis. Studies have shown that impaired immune system function plays a role in the development of endometriotic lesions. One type of immune cells that may contribute to the pathogenesis of endometriosis is the natural killer (NK) cells. NK cells are components of the innate immune system and play a critical role in defending against infections and eliminating abnormal cells, including cancerous cells. They are also involved in maternal-fetal tolerance and maintaining reproductive health. Increasing evidence suggests that both the function and number of NK cells are altered in endometriosis. Furthermore, recent research has shown promising results regarding the potential role of NK cells in the treatment of endometriosis.
Type of Study: Review article |
Subject:
Immunology
Received: 2025/06/30 | Accepted: 2025/09/15 | Published: 2026/07/6
Received: 2025/06/30 | Accepted: 2025/09/15 | Published: 2026/07/6
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