Volume 33, Issue 12 (3-2026)
JSSU 2026, 33(12): 9711-9723 |
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Forghani M S, Jafari F, Mirhosseini H, Avazbakhsh M H. Investigating the Effect of the Injection Speed of the Combination of Neostigmine and Atropine on the Heart Rate of Patients under General Anesthesia in Shahid Rahnamoun Hospital, in Yazd City in 2021. JSSU 2026; 33 (12) :9711-9723
URL: http://jssu.ssu.ac.ir/article-1-6211-en.html
URL: http://jssu.ssu.ac.ir/article-1-6211-en.html
Abstract: (11 Views)
Introduction: A large number of surgical procedures are performed worldwide each year, and it is essential to take precautions to ensure maximum patient safety. The combination of atropine and neostigmine, commonly known as reversal, is administered at the end of surgery to counteract the effects of muscle relaxants; however, it may influence cardiovascular stability. The aim of this study was to find a way to minimize this impact.
Methods: The present study was conducted as a double-blind clinical trial involving 69 patients who were candidates for various surgical procedures and met the inclusion criteria. Participants were selected purposively and randomly divided into three groups based on the reversal injection speed (10 seconds, 1 minute, and 3 minutes). Heart rate was measured and recorded using a data checklist- first at the end of the operation and before the reversal injection, and then at different intervals after the injection. Then, the data was entered into SPSS version 26 software and analyzed using descriptive statistical methods.
Results: The variables of gender and injection speed significantly affected changes in heart rate. Specifically, the mean heart rate variation was higher among female patients than male ones, and lower in the 3-minute injection group compared to the other groups.
Conclusion: Administrating the reversal drug over three minutes resulted in the smallest alternations in patients' heart rates following surgery.
Methods: The present study was conducted as a double-blind clinical trial involving 69 patients who were candidates for various surgical procedures and met the inclusion criteria. Participants were selected purposively and randomly divided into three groups based on the reversal injection speed (10 seconds, 1 minute, and 3 minutes). Heart rate was measured and recorded using a data checklist- first at the end of the operation and before the reversal injection, and then at different intervals after the injection. Then, the data was entered into SPSS version 26 software and analyzed using descriptive statistical methods.
Results: The variables of gender and injection speed significantly affected changes in heart rate. Specifically, the mean heart rate variation was higher among female patients than male ones, and lower in the 3-minute injection group compared to the other groups.
Conclusion: Administrating the reversal drug over three minutes resulted in the smallest alternations in patients' heart rates following surgery.
Type of Study: clinical trial |
Subject:
Pharmacology
Received: 2024/05/12 | Accepted: 2025/03/1 | Published: 2025/05/5
Received: 2024/05/12 | Accepted: 2025/03/1 | Published: 2025/05/5
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