Volume 25, Issue 7 (oct 2017)                   JSSU 2017, 25(7): 556-563 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Samiee Rad F, Jahani Hashemi H, Sofiabadi M, Bahrami H. Evaluation of severity of preeclampsia with mother’s serum high sensitive C-reactive protein (Hs-CRP) . JSSU. 2017; 25 (7) :556-563
URL: http://jssu.ssu.ac.ir/article-1-4122-en.html
Abstract:   (3392 Views)
Introduction: Preeclampsia is one of the most common complications in pregnancy and a main cause of death in the perinatal period. The early diagnosis of severe disease form is important. The aim of this study was to evaluate the relationship between the serum high sensitive C - reactive protein (hs-CRP) and severity of preeclampsia.
Methods: This cross-sectional study conducted between 2013 October -2014 February in third trimester pregnant women that had been admitted to Qazvin Kosar Hospital they were divided into three groups as: the first included 50 healthy pregnant women (control), the second included 45 women with mild preeclampsia and the third group included 42 women with severe pre-eclampsia. Blood pressure was measured after at least 10 minutes resting in a sitting position. Blood samples were taken six hours after admission and the hs-CRP measured by immunoturbidometric method using bionic kit. Data were analyzed using ANOVA, x2 and Kruskal-Wallis tests.
Results: The average serum levels of hs-CRP were 2.4 in the control, 8.7 in the mild and 32.6 in the severe preeclampsia groups and this difference were significant in all the three groups.
Conclusion: According to the results, it seems that the serum levels of hs-CRP can be used in the prediction and diagnosis of the severity of preeclampsia.
Full-Text [PDF 1041 kb]   (1761 Downloads)    
Type of Study: Original article | Subject: Obstetrics
Received: 2017/02/20 | Accepted: 2017/07/29 | Published: 2017/11/15

1. Garshasbi A, Fallah N. Maternalhematocrite level and risk of low birthweight and preterm delivery. Tehran University Medical J (TUMJ) 2006; 64(4): 87-94.
2. Alahyari E, Rahimi Foroushani A, Zeraati H, Mohammad K, Taghizadeh ZA . Predictive Model for the Diagnosis of Preeclampsia. J Reprod Infertil 2010; 10(4): 329.
3. Sibai BM .Diagnosis and management of gestational hypertention and preeclampsia.Am J Obstet Gnyecol 2003; 102(1): 181-92.
4. Schoenaker DA, Soedamah-Muthu SS, Mishra GD.The association between dietary factors and gestational hypertension and pre-eclampsia: a systematic review and meta-analysis of observational studies.BMC Med 2014; 12: 157.
5. Ghomian N. Investigation of duration of activity phase and method delivery in primipar with preeclampsia. Reza Behzistan 2003; 10(4): 6-9. [Persian]
6. Lelia Duley, obstetric epidemiologist, Shireen Meher, registrar, Edgardo Abalos. Management of pre-eclampsia.BMJ 2006 Feb 25; 332(7539): 463–468.
7. Lawlor DA, Morton SM, Nitsch D, leon DA. Association between childhood and adulthood socioeconomic position and pregnancy induced hypertention: Results from the Aberdeen children of the 1950s cohort study .J Epidemiol Community Health 2005; 59(1): 49-55.
8. Conde-Agudelo A,Belizan JM .Risk factors for preeclampsia in a large cohort of Latin American and Cribben women.Br J Obstet Gynaecol 2000; 107(1): 75-83.
9. Kovo M1, Schreiber L, Elyashiv O, Ben-Haroush A, Abraham G , Bar J. Pregnancy outcome and placental findings in pregnancies complicated by fetal growth restriction with and without preeclampsia. Bar J.Reprod Sci 2015; 22(3): 316-21.
10. Wang Y,Gu Y, Zhang Y,Lewis DF.Evidence of endothelial dysfunction in preeclampsia :decreased endothelial nitric oxcide synthase expression in associated with increased cell permeability in endothelial cells from preeclampsia.Am J Obstet Gynecol 2004; 190(3): 817-24.
11. Ridker PM, glynn RJ, Hennekens CH. C-reactive protein adds to the predictive value of total and HDL cholesterol in determining rik of first myocardial infraction.Circulation 1998; 97(20): 2007-11.
12. Sachin J, Vidhi G, Sania N. Acute-phase proteins: As diagnostic tool. J Pharm Bioallied Sci 2011; 3(1): 118-27.
13. Tushika B, Anita P, Deepa D, Ashish K. C - reactive protein (CRP) and its Association with Periodontal Disease: A Brief Review. J Clin Diagn Res. 2014; 8(7): ZE21–ZE24.
14. Jain S, Gautam V, Naseem S. Acute-phase proteins: As diagnostic tool.J Pharm Bioallied Sci 2011; 3(1): 118-127.
15. Malek A ,Bersinger NA ,Di Santo S, Mueller MD, sager R ,Schneider H,et al .C –reactive protein production in term human placental tissue.Placenta 2006; 27(6-7): 619-25.
16. Parker ES, Gissler M, Cande VA, Werler WW. Induced Abortions and the Risk of Preeclampsia Among Nulliparous Women. Am J Epidemiol 2015; 182(8): 663–669.
17. Hwang HS, Kwon JY, Kim MA, Park YW, Kim YH. Maternal serum highly sensitive C-reactive protein in normal pregnancy and pre-eclampsia. Int J Gynaecol Obstet 2007; 98(2): 105-109.
18. Oancea Mihaela D, Costin N, Pop Daria M, Ciortea R, Trif I, Mihu D. Evaluation of Infl ammatory Markers in PregnantWomen at Risk, for the Prediction of Preeclampsia. Acta Medica Marisiensis 2014; 60(3): 94-98
19. Nanda K, Sadanand G, Muralidhara Krishna CS, Mahadevappa KL. C-Reactive protein as a predictive factor of preeclampsia. Int J Biol Med Res 2012; 3(1): 1307-310.
20. Ayatollahi H, Hasanzade M, Farzadnia M, Khabbaz Khoob M, Rahmanian A. Serum Level of high Sensitive C-Reactive Protein in Normal and Preeclamptic Pregnancies. Iran J pathology 2007; 2(3): 100-4.
21. Savvidou MD, Lees CC,Parra M, Hingorani AD,Nicolaides KH.Levels of C-reactive protein in pregnant women who subsequently develop preeclampsia .BJOG 2002: 109(3): 297-301.
22. Gandevani SB, Banaem LM, Mohamadi B, Moghadam NA, Asghari M. Association of high-sensitivity C - reactive protein serum levels in early pregnancy with the severity of preeclampsia and fetal birth weight. J Perinat Med 2012; 40(6): 601-5.
23. 23- Ghosh TK, Ghosh S, Bhattacharjee D. C- reactive protein levels in women with pregnancy induced hypertension. BJMS 2011; 10(3): 159-162.

Add your comments about this article : Your username or Email:

Send email to the article author

© 2021 All Rights Reserved | SSU_Journals

Designed & Developed by : Yektaweb