Volume 25, Issue 6 (Aug 2017)                   JSSU 2017, 25(6): 426-435 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jalilzadeh-Amin G, Anassori E, Namvar M. Effects of Artemisia dracunculus Essential Oil on Blood Lipid Profiles in Hyperlipidemic Rat . JSSU. 2017; 25 (6) :426-435
URL: http://jssu.ssu.ac.ir/article-1-3645-en.html
Abstract:   (3977 Views)
Introduction: Hyperlipidemia and elevated serum total cholesterol is one of the greatest risk factors contributing to prevalence and severity of cardiovascular complications like coronary heart diseases, including atherosclerosis and death. To clarify the anti-hyperlipidemic effect of Artemisia dracunculus essential oil (ADEO), the present experimental study was designed.
Methods: The EOAD was extracted by clevenger apparatus using hydrodistillation. Hyperlipidemia was induced by giving high cholesterol (2%) diet in standard rat chow diet for twenty-one days. Animals were randomly divided into 6 groups (there were 6 rats in each groups). The groups of rats selected for the study were treated orally with lovastatin (10 mg/kg) and EOAD (15–60 mg/kg) daily for the two weeks.
Results: EOAD did not show significant difference in serum cholesterol (TC) and triglycerides (TG), but these values were lowered significantly (P< 0.05( by lovastatin. Also, there was a significant (P< 0.05 (increase in high density lipoprotein (HDL) levels after the treatment with EOAD. Marked decrease (P< 0.05( in low density lipoprotein (LDL) concentrations was observed in rats fed the lovastatin and EOAD (60 mg/kg) than in the control group. There was a significant reduction in TG: HDL, TC: HDL, LDL: HDL ratios and ath+rogenic index in the EOAD treated groups.
Conclusion: The present work indicated that essential oil of A. dracunculus could not prevent dyslipidemia that occurred in rats following feeding of high cholesterol diet in both dose-and time-dependent manners. However, it was affected HDL level and athrogenic index. Further studies are needed to characterize the effects of A. dracunculus in the prevention and treatment of atherosclerosis.
Full-Text [PDF 595 kb]   (1344 Downloads)    
Type of Study: Original article | Subject: Endocrinology and Metabolism
Received: 2016/03/8 | Accepted: 2016/09/24 | Published: 2017/10/17

1. Choudhary MI, Naheed S, Jalil S, Alam JM, Atta ur R. Effects of ethanolic extract of Iris germanica on lipid profile of rats fed on a high-fat diet. J Ethnopharmacol 2005; 98(1-2): 217-20.
2. Saravanakumar A, Vanitha S, Ganesh M, Jayaprakash J, Ramaswamy N. Hypolipidemic activity of Sesbania grandiflora in triton wr-1339 induced hyperlipidemic rats. Int J Phytomediation 2011; 2: 52-58.
3. Kayamori F, Igarashi K. Effects of dietary nasunin on the serum cholesterol level in rats. Biosci Biotechnol Biochem 1994; 57(3): 570-1.
4. Singh BB, Vinjamury SP, Der-Martirosian C, Kubik E, Mishra LC, Shepard NP, et al. Ayurvedic and collateral herbal treatments for hyperlipidemia: a systematic review of randomized controlled trials and quasi-experimental designs. Altern Ther Health Med 2007; 13(4): 22-28.
5. Anila L, Vijayalakshmi NR. Flavonoids from Emblica officinalis and Mangifera indica-effectiveness for dyslipidemia. J Ethnopharmacol 2002; 79(1): 81-7.
6. Roghani M, Baluchnejadmojarad T, Roghani-Dehlordi F. Effect of oral Artemisia drucunculus on glucose and lipid profile in insulin associated diabetic rats. Iranian J Endocrinology and Metabolism. 2005; 23: 235-39. [Persion]
7. Jafari Dinani N, Asgary S, Madani H, Naderi Gh, Mahzoni P. Hypocholesterolemic and antiatherosclerotic effect of Artemisia aucheri in hypercholesterolemia rabbits. Pak J Pharm Sci 2010; 23(3): 321-5.
8. Rafati A, Yaghmaei P, Moradi S, Ismaeili-Dahadje M, Jalali B. Comparison of the efficiency of Lovostatin and seed dill extract in reduction of serum lipid levels in rats. J Shahid Sadoughi Univ Med Sci 2006; 13(5): 41-9. [Persion]
9. Lucas EA, Wild RD, Hammond LJ, Khalil DA, Juma SH, Daggy BP, et al. Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinal Metab 2002; 87(4):1527-32.
10. Hirunpanich V, Utaipat A, Morales NP, Bunyapraphatsara N, Sato H, Herunsale A, et al. Hypocholesterolemic and antioxidant effects of aqueous extracts from the dried calyx of Hibiscus sabdariffa L. in hypercholesterolemic rats. J Ethnopharmacol 2006; 103(2): 252-60.
11. Sierens J, Hartly J, Campbell MJ, leathem AJ, Woodside JV. In vitro isoflavone supplementation reduces hydrogen peroxide-induced DNA damage insperm. Teratog Carcinog Mutagen 2002; 22(3): 227-34.
12. Dufful KG, Ngadjui BT, Simeon KF, Abegaz BM, Croft KD. Antioxidant activity of prenylated flavonoids from the Wes Afvican medicinal plant Dorsteniamanii. J Ethnopharmacol 2003; 87:67-72.
13. Zarei A, Ashtiyani SC, Rasekh F, Mohammadi A, Jabary A. The effects of Physalisalkekengi extract on lipids concentrations in rats. Arak Med Univ J 2011; 14: 48-55. [Persion]
14. Krause BR, Newton RS. Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL models. Atherosclerosis 1995; 117(2):237–44.
15. Haytham M, Daradka M, Badawneh JA, jamal A, Bataineh Y. Hypolipidemic Efficacy of Artemisia absinthium Extracts in Rabbits. World App Sci J 2014; 31(8): 1415-1421.
16. Yazdanparast R, Saei A. Effects of aqueous tarragon, Artemisia dracunculus, extract on lipid and coagulatory parameters in rats. Biomedical letters 1999; 59(233): 137-141.
17. Jang JY, Choi HJ. Effects of Artemisia Iwayomogi Oligosaccharide on the Blood Lipids, Abdominal Adipose Tissues and Leptin Levels in the Obese Rats. The Korean Journal of Nutrition 2003; 36(5): 437-45.
18. Yazdanparast R, Bahramikia S. Evaluation of the effect of Anethum graveolens L. crude extracts on serum lipids and lipoproteins profiles in hypercholesterolaemic rats. Daru 2008; 16(2): 88-94.
19. Asgary S, Jafari Dinani N, Madani H, Mahzoun P. Ethanolic extract of Artemisia aucheri induces regression of aorta wall fatty streaks in hypercholesterolemic rabbits. Pharmazie 2008; 63(5): 394–7.
20. Chen YL, Huang HC, Weng YI, Yu YJ, Lee YT. Morphological evidence for the antiatherogenic effect of scoparone in hyperlipidaemic diabetic rabbits. Cardiovascular Res 1994; 28(11): 1679-85.
21. Harrison D, Kathy KG, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol 2003; 91(3): 7–11.
22. Weggemans RM, Trautwein EA. Relation between soy-associated isoflavones and LDL and HDL cholesterol concentrations in humans: a Meta analysis. Eur J Clin Nutr 2003; 57(8): 940–6.
23. Bouderbala AS, Lamri-Senhadji M, Prost J, Lacaille-Dubois MA, Bouchenak M. Changes in antioxidant defense status in hypercholesterolemic rats treated with. Phytomedicine 2008; 15(6-7): 453–61.
25. 24- Kim KS, Lee S, Lee YS, Jung SH, Park Y, Shin KH, et al. Antioxidant activity of the extracts from the herbs of Artemisia apiacea. J Ethnopharmacol 2003; 85(1): 69-72.
26. 25- Marrif H, Ali BH, Hassan KM. Some pharmacological studies on Artemisia herba- alba in rabbits and mice. J Ethnopharmacol 1995; 49(1): 51-5.
27. 26- Nazari A, Delfan B, Shahsavari G. The effect of Satureja khuzestanica on triglyceride, glucose, creatinine and alkaline phosphatase activity in rat. J Shahrekord Univ Med Sci 2005; 7:1-8. [Persion]

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | SSU_Journals

Designed & Developed by : Yektaweb