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Introduction: The first outcome of living with low physical activity is weight gain over time, which is associated with the onset and development of cardiovascular disease. In regard to importance of Apo I-A in the process of reverse cholesterol transport and producing HDL particles, this study aimed to compare the effects of aerobic and resistance training on Apo I-A in overweight women . Methods: By a paper recall, 24 overweight women were selected and randomly assigned into aerobic, resistance and control groups. The aerobic group were required to exercise based on aerobic program three days per week for 2 months, the resistance group accomplished resistance exercises in the same time manner, and the control group remained sedentary. Forty-eight hours before and after the two-month program, blood samples were obtained from all subjects in the same conditions. BFP, HDL, LDL and Apo I-A were measured via one-way ANOVA with between group factor methods using SPSS software version 16. Results: The results demonstrated that two months of aerobic exercise significantly decreased BFP and LDL levels (p=0.00092, p=0.00056 respectively). Levels of HDL and Apo I-A significantly increased compared to the control group ( p=0.0022, p=0.00391 respectively). Moreover due to the two month resistance training, BFP and LDL levels significantly decreased (p=0.00238 and p=0.00066 respectively), whereas levels of HDL and Apo I-A significantly increased (p=0.0254 and p=0.00519 respectively). Conclusions: Overweight women regardless of the type of training can engage in regular physical activity which in addition to the weight loss, they can benefit by improving levels of lipoproteins and reverse cholesterol transport, as well as by preventing the cardiovascular disease.

Keywords: Apolipoprotein, Obesity, Physical activity, Reverse transport of cholesterol

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