Volume 29, Issue 10 (1-2022)                   JSSU 2022, 29(10): 4164-4179 | Back to browse issues page


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Khalili A. A Review of Primary Immunodeficiency Diseases with Skin Manifestations. JSSU. 2022; 29 (10) :4164-4179
URL: http://jssu.ssu.ac.ir/article-1-5396-en.html
Abstract:   (678 Views)
Introduction: Primary immunodeficiencies (PID) are rare heterogeneous disorders with defects in which one or more components of the immune system are malfunctioning. Clinical presentations of the patients according to type of immunodeficiency are variable. The majority of these patients are susceptible to infections depending on the type of disorder. In these patients, one of the most important and common symptoms is a skin manifestation that in many cases helps to diagnose the disease. Skin symptoms can include infectious-inflammatory-autoimmune-allergic manifestations and malignancies. In some cases, skin involvement can be the initial manifestation of immunodeficiency diseases, so understanding the relationship between the type of primary immunodeficiency and the type of skin involvement is very important in diagnosing the disease. The majorities of skin diseases are not pathogenomonic in primary immunodeficiencies and may be seen in other diseases with normal levels of immunity. However, there are numerous skin findings that are so characteristic of immunodeficiency diseases that it is necessary to evaluate the immune system.
Conclusion: Skin is an organ that may be involved in many diseases, including primary immunodeficiency. Sometimes skin is the first organ involved in immune deficiencies. Therefore, recognizing skin manifestations in these patients is one of the most important factors in early diagnosis of these people.
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Type of Study: Review article | Subject: Immunology
Received: 2021/03/9 | Accepted: 2021/07/25 | Published: 2021/12/31

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