Volume 28, Issue 5 (7-2020)                   JSSU 2020, 28(5): 2660-2672 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rokhsati S, Souri R, Shabkhiz F, Rabbani S, Shahsavari Z. Effect of High Intensity Interval Training on the Level of Atrial Fibrillation, Fibroblast Growth Factor 23 and Klotho Protein in Male Rats with Renal Failure. JSSU. 2020; 28 (5) :2660-2672
URL: http://jssu.ssu.ac.ir/article-1-5115-en.html
Abstract:   (1163 Views)
Introduction: Cardiovascular problems and atrial fibrillation is one of the most prevalent secondary consequences in hemodialysis patients. This study aimed to examine the effect of high intensity interval training on the level of atrial fibrillation, fibroblast growth factor 23 and Klotho in male rats with chronic kidney disease.
Methods: In this study, 30 male rats Wistar (7-8 weeks) were randomly assigned into three groups of exercise, control and sham. Rats in the exercise and control groups were entered to the study by using nephrectomy 5/6Nx, which made renal failure. Exercise protocol included training protocol as high intensity interval training (85% Maximum oxygen consumption) on treadmill for 8 weeks and three sessions in each week. Atrial fibrillation, fibroblast growth factor 23, Klotho, and other parameters were examined at the post intervention in all three groups. Data analysis was performed by one-way ANOVA and to examine the difference between groups, followed post-hoc Bonferroni analysis test at P <0.05.
Results: Interval training was able to make a significant difference between the exercise and control groups in the level of atrial fibrillation (P<0/05). Klotho protein also had a considerable increase in the exercise group compared to the control group. However, the fibroblast growth factor 23 did not differ significantly between the exercise and control groups (P>0/05).
Conclusion: High intensity interval training can cause a significant decrease in the level of atrial fibrillation in chronic kidney patients; however, in the process of this improvement, the changes in fibroblast growth factor 23 and related factors are less and the role of Klotho protein has an important effect.
Full-Text [PDF 1102 kb]   (385 Downloads)    
Type of Study: Original article | Subject: Exercise Physiology
Received: 2020/04/6 | Accepted: 2020/07/31 | Published: 2020/07/31

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | SSU_Journals

Designed & Developed by : Yektaweb