Volume 27, Issue 1 (Apr 2019)
JSSU 2019, 27(1): 1175-1186 |
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zare shehneh M, kalantar S M, Sheikhha M H, asri kojabad A, Haghiralsadat B F. Study of anti-cancer effects of Curcumin; formulation of Curcumin-loaded nano carrier and its toxicity effect on MCF-7 Cell line.. JSSU 2019; 27 (1) :1175-1186
URL: http://jssu.ssu.ac.ir/article-1-4574-en.html
URL: http://jssu.ssu.ac.ir/article-1-4574-en.html
Masoud Zare shehneh 
, Seyed mehdi Kalantar , Mohammad Hasan Sheikhha , Amir Asri kojabad , Bibi fatemeh Haghiralsadat *
, Seyed mehdi Kalantar , Mohammad Hasan Sheikhha , Amir Asri kojabad , Bibi fatemeh Haghiralsadat *
Abstract: (4141 Views)
Introdution: Nanotechnology introduced new methods to chemotherapy drugs delivery into cancer cells to reduce the side effect of drugs it increases the quality of cancer treatment and reduces the side effects of chemotherapy. . In this study, different lipid formulations of nucliposomes containing curcumin was prepared by thin-layer method and evaluated for chemical-physical evaluation on MCF-7 cell line.
Methods: This study was a descriptive-analytic. Various formulations of liposomes prepared from Span 60, SPC and cholesterol. Curcumin was loaded in the liposomes. Final liposome formulation selected and PEGylated. The Optimal formulation characterized by DLS, FT-IRT, Fe-SEM and SEM. Statistical analysis was performed with Prism6 software.
Results: The average size of liposomes, encapsulation efficacy of liposomal loaded curcumin and Zeta potential was about 63.9 nm, -41mV and %95.58, respectively. Liposomes exhibited the slowest release rate in normal and turmeric cell culture condition. To compare the function of free curcumin in similar concentrations, liposomal curcumin formulation was %63 toxic to MCF7 Cell line.
Conclusion: The present study shows that an optimally optimized nanoliposome with curcumin having appropriate physicochemical properties, improving drug toxicity in cancerous cell lines and increasing drug stability can be a good vector for drug delivery to breast cancer cells.
Conclusion: The present study shows that an optimally optimized nanoliposome with curcumin having appropriate physicochemical properties, improving drug toxicity in cancerous cell lines and increasing drug stability can be a good vector for drug delivery to breast cancer cells.
Methods: This study was a descriptive-analytic. Various formulations of liposomes prepared from Span 60, SPC and cholesterol. Curcumin was loaded in the liposomes. Final liposome formulation selected and PEGylated. The Optimal formulation characterized by DLS, FT-IRT, Fe-SEM and SEM. Statistical analysis was performed with Prism6 software.
Results: The average size of liposomes, encapsulation efficacy of liposomal loaded curcumin and Zeta potential was about 63.9 nm, -41mV and %95.58, respectively. Liposomes exhibited the slowest release rate in normal and turmeric cell culture condition. To compare the function of free curcumin in similar concentrations, liposomal curcumin formulation was %63 toxic to MCF7 Cell line.
Conclusion: The present study shows that an optimally optimized nanoliposome with curcumin having appropriate physicochemical properties, improving drug toxicity in cancerous cell lines and increasing drug stability can be a good vector for drug delivery to breast cancer cells.
Conclusion: The present study shows that an optimally optimized nanoliposome with curcumin having appropriate physicochemical properties, improving drug toxicity in cancerous cell lines and increasing drug stability can be a good vector for drug delivery to breast cancer cells.
Type of Study: Original article |
Subject:
Oncology
Received: 2018/05/28 | Accepted: 2018/06/23 | Published: 2019/05/13
Received: 2018/05/28 | Accepted: 2018/06/23 | Published: 2019/05/13
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