Volume 23, Issue 10 (Jan 2016)                   JSSU 2016, 23(10): 912-922 | Back to browse issues page

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Azami M, Tardeh Z, Abangah G, Sayemiri K. The Prevalence of Impaired Glucose Tolerance in Patients with Thalassemia Major in Iran: A systematic Review and Meta-analysis. JSSU. 2016; 23 (10) :912-922
URL: http://jssu.ssu.ac.ir/article-1-3318-en.html
Abstract:   (10066 Views)

Introduction: Impaired glucose tolerance (IGT) is one of the most common endocrine complications in major thalassemia patients. IGT prevalence in patients with thalassemia major has been differently in different studies in Iran, about which no total estimate can be proposed. Hence, this meta analysis study aimed to investigate IGT prevalence in major thalassemia patients in Iran.

Methods: This study was a systematic review based on electronic databases including Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, Sciencedirect, Cochrane, Embase, Web of Science, Springer, Online Library Wiley as well as Google Scholar search engine without any time limitations up to 2015. All the potentially relevant papers were reviewed independently by two investigators using the standard key words. Then, all the reviewed studies that had inclusion criterion were evaluated. In order to statistically analyze the study data, random effect model was used via Stata software (Ver.11.1).

Results: 1346 subjects were examined in 13 studies. IGT prevalence in patients with thalassemia major was estimated 9.6 %( CI: 95%, 6.6-12.5) in Iran. The IGT prevalence in male and female major thalassemia patients were 6.5 %( CI: 95%, 1.6-11.3) and 10.2 %( CI: 95% , 6.1-14.3), respectively.

Conclusion: IGT Prevalence was demonstrated to be really high in patients with thalassemia major. As a result, implementing screening programs seems to be necessary in regard with early diagnosis of endocrine disorders especially IGT in these patients. Furthermore, it is recommended that annual glucose tolerance test be taken within such patients.

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Type of Study: Review article | Subject: Endocrinology and Metabolism
Received: 2015/07/18 | Accepted: 2015/10/19 | Published: 2016/01/5

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