Evaluation of the Antinociceptive Effect of Hydroalcoholic Extract of Potentilla Reptans L. in the Adult Male Rat

Mahmoodi , M; Mohammadi, S; Enayati , F

Volume 24, Issue 3 (Jun 2016) JSSU 2016, 24(3): 201-210 | Back to browse issues page

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Mahmoodi M, Mohammadi S, Enayati F. Evaluation of the Antinociceptive Effect of Hydroalcoholic Extract of Potentilla Reptans L. in the Adult Male Rat. JSSU 2016; 24 (3) :201-210
URL: http://jssu.ssu.ac.ir/article-1-3153-en.html

Evaluation of the Antinociceptive Effect of Hydroalcoholic Extract of Potentilla Reptans L. in the Adult Male Rat

M Mahmoodi

, S Mohammadi ^*

, F Enayati

Abstract: (8039 Views)

Introduction: Medicinal plants have been a focus of attention to researchers due to their fewer side effects in treating diseases comared to chemical drugs. Some health properties of medicinal plants such as anti-hypercholesterolemia and antioxidant effects of Potentilla reptans have been proven. Therefore, the present study aimed to investigate the antinociceptive and analgesic effect of hydro-alcoholic extract of Potentilla reptans L. (HEP) in the male rat.

Methods: In this experimental study, 36 male rats were divided into 6 groups, including: control group (normal saline), morphine group (1mg/kg), HEP groups (treated with 25, 50 and 100 mg/kg), and naloxone group (200 mg/kg). Writhing, formalin and tail-flick tests were used to evaluate the analgesic effects of the extract. In order to analyze the study data, variance and Tukey test were applied.

Results: The results of the present study demonstrated that in writhing test (P<0.05 and P<0.001 respectively), formalin test (P<0.05, P<0.001) and tail-flick test (P<0.05, P<0.01); the injection of 50, and 100mg/kg dose of the extract produced significant analgesic effects compared with the control group. 50mg/kg dose of Naloxone injection extract has shown a significant analgesic effect in the formalin test (P<0.05). In addition, the effect of the analgesic dose of 100mg/kg of the extract in formalin test was similar to that of morphine.

Conclusions: The findings of the current study revealed that Potentilla reptans L. (HEP) has a significant analgesic effect. Opioid pathway seems to be one of the possible mechanisms of extract effects, which further clinical trials are recommended in this case.

Keywords: Anti-nociceptive, Pain, Potentilla reptan, Rat

Full-Text [PDF 673 kb] (2450 Downloads)

Type of Study: Original article | Subject: Pharmacology
Received: 2015/03/15 | Accepted: 2015/10/3 | Published: 2016/06/6

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