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Introduction: Preoperative anxiety is known as a complaint in the majority of patients referring to surgery. Considering the effect of some medicinal plants as anti anxiety and sedative, this study was conducted to compare the effectiveness of Citrus Aurantium and oxazepam tablets on anxiety before coronary artery bypass graft. Methods: In this clinical trial, 66 patients, aged 40-65, were selected and randomly divided into two groups, who underwent coronary artery bypass graft surgery in Namazee and Shahid Faghihi Hospitals. Patients in group A (33 patients) received 10 ml (equivalent to 2 mg) of Citrus Aurantium per day for three days before surgery, and patients in group B (33 patients) took a tablet of Oxazepam (10 mg) in a single dose orally, the night before the operation. The patients’ anxiety was measured by Spielberger Anxiety Inventory. Moreover, the study data was analyzed by using t-test and paired t-test in SPSS software. Results: The study results revealed that anxiety in Citrus Aurantium group decreased significantly (P=0.00) after the intervention, whereas in oxazepam group, although anxiety levels decreased, the difference was not reported to be significant (P=0.29). In comparing anxiety level changes between the two groups, the difference was not observed to be significant (P=0.23). Conclusion: The results obtained from the present study indicated both Citrus Aurantium and Oxazepam tablets have similar effects on anxiety. Therefore, Citrus Aurantium can be used as an effective drug to reduce anxiety in patients before surgery.

Keywords: Anxiety, Citrus Aurantium, Coronary Artery Bypass Graft, Oxazepam Tablets, Surgery

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