Volume 20, Issue 6 (Jan-Feb 2013)
JSSU 2013, 20(6): 716-723 |
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Naghsh N, Amirkhani-Dehkordi S, Aghababa H. Investigating Nanosilver Effects on Blood Cells Counter in Male Rats . JSSU 2013; 20 (6) :716-723
URL: http://jssu.ssu.ac.ir/article-1-2282-en.html
URL: http://jssu.ssu.ac.ir/article-1-2282-en.html
Abstract: (8872 Views)
Introduction: Nanosilver particles are one of the functional grounds in nanotechnology field. These nanoparticles may produce free radicals and destruct different cells. In this study, Nanosilver toxic effects on RBC and WBC numbers in male Rats were studied. Thus, male rats were treated with nanosilver and RBC and WBC were detected.
Methods: In this study, RBC was detected in male Wistar rats following exposure to 50, 100, 200 and 400ppm concentration of silver nanoparticles administrated peritoneally.
Then, RBC and WBC were collected in rats 3, 8 and 12 days after treatment of nanosilver particles. Numbers of RBC and WBC were compared in treatment and control groups.
Results: The study results indicated that dose of 400ppm nanosilver was effective on decrease of RBC and increase of WBC in treatment rats 12 day after treatment. These results were significant (p≤0/01).
Discussion: The efficiency of 400ppm concentration of nanosilver, RBC decease and WBC increase could be referred to probabale lyses of RBC cell membranes and sever incitement of cellular immune system. The extra investigation is recommended regarding variety of new shapes, sizes and composition of nanosilver.
Keywords: Nanosilver; Rat; RBC; Toxic effects; WBC
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