Volume 19, Issue 4 (Sep-Oct 2011 2011)                   JSSU 2011, 19(4): 533-541 | Back to browse issues page

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Karimi S, Taherianfard M, Bahaoddini A, Fazeli M. Interaction of Electromagnetic Field and Modulation of GABA-B Receptor on Serum Testosterone Concentration in Aggressive Rats. JSSU. 2011; 19 (4) :533-541
URL: http://jssu.ssu.ac.ir/article-1-1641-en.html
Abstract:   (7896 Views)
Introduction: The aim of the present study is to investigate the effect of interaperitoneal injection of baclofen (GABA-B agonist) and CGP35348 (GABA-B antagonist) on serum testosterone concentration in aggressive rats exposed to electromagnetic field. Methods: Fifty five mature male rats weighing 200±20 grams were studied. Animals were divided into 2 main groups and four subgroups. Main groups composed of rats with and without exposure to electromagnetic field. Animals in the former group were exposed to electromagnetic field with 500 T intensity and 50Hz frequency for 8 hours a day for 30 days. Aggression was induced by applying 2mA current every 3 seconds for 5 minutes. Then serum testosterone concentration was measured by radioimmunoassay method. Results: Data showed that baclofen injection at 3mg/kg and CGP35348 at 100mg/kg significantly increased serum testosterone concentration in aggressive rats exposed to electromagnetic field. Conclusion: According to the simillar effect of baclofen and CGP35348 on testosterone secretion, it seems that GABA-B receptors in testes are two types, so it has caused similar effects. Also, electromagnetic exposure leads to increase in testosterone secretion.
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Type of Study: Original article | Subject: General
Received: 2011/10/5 | Published: 2011/10/15

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