Volume 18, Issue 4 (Sep-Oct 2010)
JSSU 2010, 18(4): 330-336 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Sheikhha M, Ghasemi N, Nazem H, Homaei A, Haghirossadat F. Comparison of the Rate of Mu Receptor Gene Single Nucleotide Polymorphism in Addicts and Non Addicts. JSSU 2010; 18 (4) :330-336
URL: http://jssu.ssu.ac.ir/article-1-1143-en.html
URL: http://jssu.ssu.ac.ir/article-1-1143-en.html
Comparison of the Rate of Mu Receptor Gene Single Nucleotide Polymorphism in Addicts and Non Addicts
Abstract: (11352 Views)
Introduction: The importance of scientific research in prevention of drug addiction is obvious. The main site of drug action is the brain. Mu receptor is the first place of drug action. In this study, the rate of mu receptor gene single nucleotide polymorphism (SNP) was compared in addicts and non-addicts.
Methods: In this study AA, AG and AA polymorphism of mu receptor gene was investigated in 47 addicts and 30 non-addicts (controls). DNA was extracted by salting out method from peripheral blood and the PCR-Arms was performed.
Results: In control group, 66.7% had AA polymorphism while 68.1% of addict group showed this polymorphism. The AG polymorphism was 30% and 27.7% in control and addict groups, respectively. The GG polymorphism was 3.3% in control and 4.3% in addict group. There were no significant differences between the two groups.
Discussion: Our results indicated that there is no relationship between the mu receptor gene SNP and addiction. The other SNPs in this gene and other genes must be investigated. In addition, it seems that other factors such as environmental factors could play a role in addiction.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
