20 2228-5741 Shahid Sadoughi University of Medical Sciences 5920 Rheumatology New Insights into Pathogenesis, Diagnosis and Treatment of Psoriatic Arthritis Dadgar Farhad b Rostamian Abdolrahman c Najafizadeh Seyed Reza d Movaseghi Shafieh e Saffarian Zahra f b Department of Internal Medicine, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran c Department of Rheumatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. d Rheumatology Research Center, Vali-e-Asr Hospital ,Tehran University of Medical Sciences, Tehran, Iran. e Department of Rheumatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. f Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. 1 9 2023 31 6 6705 6717 19 01 2023 15 03 2023 Introduction: Psoriatic Arthritis (PSA) is an inflammatory musculoskeletal disorder characterized by significant dysfunction in synovial tissue, tendons and axial sites. PSA is associated with metabolic comorbidities such as diabetes, obesity, congestive heart failure, fatty liver disease, depression and/or anxiety. Due to differences in the clinical manifestations of PSA, some patients are not diagnosed through clinical examination. Delayed psoriatic arthritis diagnosis or consultation has been related to low quality of life and increased frequency of comorbidities and persistent inflammatory state. The aim of the present study was to explore multiple etiologies of PSA, screening tools, and pharmaceutical therapy. Articles were searched from international databases including Magiran, Scopus, Google Scholar, PubMed, and Springer. The keywords of Psoriatic Arthritis, Screening tools, pathogenesis, treatment, and Biomarkers were used to extract articles. Conclusion: Our study showed that heterogeneity in the etiology of PSA was a major reason for classification problems within this disease spectrum. The explanation for this disease heterogeneity may be focused on variations in genetic and environmental factors. Screening strategies (ex: CASPAR criteria and biomarkers) are a significant first step in early treatment. Moreover, many types of therapy are available to help decreased joint problems, muscle weakness, and disease severity. Detection of dependent factors related to PSA might help in the early intervention of these patients to address clinical and para-clinical issues. Here we have provided an updated review of the early diagnosis, clinical features, pathogenesis, screening tools, biomarkers, and treatment recommendations, such as new biologic medications, for Psoriatic Arthritis.  
5815 Genetics Evaluate the Effect of Dendrosomal Curcumin on Expression Level of HOTAIR Long Noncoding RNA in MCF-7 Breast Cancer Cell Line Mehrabi Maryam g Alemohammad Sara h Dashtebozorgi Reza i Tahmasebi Birgani Maryam j Hajjari Mohammad Reza k Mohammadi-Asl Javad l g Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. h Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. i Department of Genetics, Science and Research Branch, Islamic Azad University, Tehran, Iran. j Department of Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. k Depatrment of Biology, Faculty of Sciences, Shahid Chamran University of Ahva, Ahvaz, Iran. l Department of Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. 1 9 2023 31 6 6718 6731 10 08 2022 13 11 2022 Introduction: Breast cancer is one of the most common malignancies in women. Treatment with herbal drugs has been considered by researchers due to the lower side effects. Curcumin is a polyphenol extracted from turmeric with confirmed anti-cancer properties. Curcumin is water-insoluble with rapid metabolism. Drug delivery using nano-carriers is suggested to overcome such limitations. The aim of this study was based on evaluating the effect of Dendrosomes curcumin on expression level of HOTAIR long noncoding RNA in MCF-7 breast cancer cell line. Methods: This study was an applied basic research. Firstly, curcumin was loaded in dendrosomes and the entry of dendrosomal curcumin into cells was studied using fluorescent microscopy.  Cell death was investigated using MTT assay and apoptosis detection kit. The expression of HOTAIR gene was measured using real-time PCR. Increased expression of this gene was reported in a wide range of tumors. The data were analyzed using GraphPad Prism V9.5 statistical software, using NOVA one-way statistical analysis and Student t-test; the results were reported as mean ± standard deviation. Results: Dendrosomes increased the solubility of curcumin. The effective inhibitory doses of dendrosomal curcumin after 24 and 48h treatment were 25 and 20 micromolar, respectively. The percent of cells undergoing early apoptosis were 22.97±0.03 and 56.22±0.05, respectively, which was statistically significant in comparison with non-treated control cells. Following 24 and 48h treatment with 20 micromolar of dendrosomal curcumin, the HOTAIR gene expression was significantly decreased (P=0.001). Conclusion: These findings suggest that dendrosomal curcumin may promote breast tumor cells toward programmed cell death by reducing HOTAIR gene expression.   5759 Oncology Factors Related to Reduced Bone Density in β-Thalassemia Major Patients: Mazandaran Thalassemia Registry Karami Hossein m Kosaryan Mehrnoush n Naderisorki Mohammad o esfandiari Fatemeh p Ghazaiean Mobin Aliasgharian Aily Fallah Hanie Shakeri Salameh Darvishi-Khezri Hadi m Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. n Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. o Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. p Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran. Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. Islamic Azad University, Sari Branch, Sari, Iran. Thalassemia Research Center (TRC), Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran. 1 9 2023 31 6 6732 6745 09 06 2022 09 10 2022 Introduction: OsteoPenia and osteoPorosis are known to be one of the main comPlications of β-thalassemia major (β-TM). The aim of this study was to determine the factors associated with decreased bone density of these Patients. Methods: Lumbar and femoral neck bone mineral density (BMD) in β-TM Patients characterized via Dual-energy X-ray absorPtiometry (DXA) to PinPoint the association of iron chelators, diabetes mellitus, serum ferritin above 3000 ng/mL, hemoglobin below 8 gr/dl, using hydroxyurea, liver siderosis and moderate to severe hePatic and cardiac siderosis with BMD. The information was collected from the thalassemia registry in 2019 and statistical analysis was Performed by STATA-13 software. Results: Out of 1959 ParticiPants with β-thalassemia major registered in the registry, 139 ones (7.09%) had bone mineral density (53 males and 86 females). The Prevalence of abnormal bone density in the lumbar and femoral neck was (52.48 to 47.66) 57.5 and (40.18 to 57.52) 48.85 Percent, resPectively. After adjusting for the effects of Possible interventions, the odds ratio of abnormal bone density in the Patients consuming hydroxyurea and deferasirox were 0.24 (0.03 to 1.73) and 0.25 (0.03 to 1.69), resPectively. The highest odds were 8.21 (0.18 to 360.22), and 6.72 (0.60 to 74.83) for moderate to severe cardiac and hePatic dePosition, resPectively. Conclusion: The Prevalence of osteoPenia and osteoPorosis is high among thalassemia major Patients. ConsumPtion of hydroxyurea and deferasirox is the most imPortant Protective factor and moderate to severe cardiac and hePatic siderosis are the most imPortant risk factors for abnormal bone density.   5916 Psychology Role of Positive Adolescent Development and Self-compassion in the Aggression Tendency of Female High School Students in Yazd City Fotoohi Fatemeh Barzegar Bafroei Kazem Hassani Hossain Psychology and Educational Sciences Department, Yazd University, Yazd, Iran. Psychology and Educational Sciences Department, Yazd University, Yazd, Iran. Psychology and Educational Sciences Department, Yazd University, Yazd, Iran. 1 9 2023 31 6 6746 6763 16 01 2023 15 03 2023 Introduction: The present study was conducted with the aim of investigating the role of positive adolescent development and self-compassion in the aggression tendency of female students of high schools in Yazd City. Methods: The research design in this study was descriptive and correlational. The participants in this research were 362 female students in the second grade of high school in Yazd City in the academic year of 2020-2021, who were selected based on random cluster sampling In order to collect data, Goldhoff et al.'s Positive Development Questionnaire (2014), Self-Compassion Questionnaire (2003) and Bass and Perry's Aggression Questionnaire (1992) were used. Data analysis and correlation method based on the approach Structural equation modeling was done using AMOS software, version 21. Results: The results showed that the positive transformation of adolescence has a direct, positive and significant effect on self-compassion (β = 0.66 and P < 0.01) and a direct, negative and significant effect on aggression (β = -0.33 and P < 0.01) and self-compassion have a direct, negative and significant effect on aggression (β = -0.29 and P < 0.01) in the female students of the second grade of high school in Yazd City. Conclusion: self-compassion plays a mediating role in the relationship between the positive development of adolescence and aggression of female students in the second grade of high school in Yazd City and by increasing the positive development of adolescence and self-compassion in adolescents, their tendency to aggression can be reduced.   5908 Surgery Epidemiological Study of Adult Patients with Acute Abdomen Referred to Fatemi Ardabil Hospital from 2020 to 2021 Arabzadeh Amir Ahmad Amini Keyvan Sharghi Afshan Ataei Mahsa Seyed Sadeghi Mirsalim Department of Surgery، School of Medicine، Imam Khomeini Hospital، Fatemi Hospital، Ardabil University of Medical Sciences، Ardabil، Iran. Department of Internal Medicine، School of Medicine، Fatemi Hospital، Ardabil University of Medical Sciences، Ardabil، Iran. Department of Social Medicine, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Department of Surgery، School of Medicine، Imam Khomeini Hospital، Fatemi Hospital، Ardabil University of Medical Sciences، Ardabil، Iran. Department of Surgery، School of Medicine، Imam Khomeini Hospital، Fatemi Hospital، Ardabil University of Medical Sciences، Ardabil، Iran. 1 9 2023 31 6 6764 6771 02 01 2023 28 05 2023 Introduction: The prevalence and causes of acute abdomen can be different in various regions and races. Knowing the epidemiology of the disease can prevent unnecessary surgeries and unwanted complications caused by surgery. The present study was conducted with the aim of epidemiological investigation of adult patients with acute abdomen referred to Fatemi Ardabil Hospital from 2020 to 2021. Methods: A cross-sectional descriptive study was conducted during a year with a statistical population of 1031 patients referred to the Emergency Department of Fatemi Ardabil Hospital with abdominal pain. The sampling method was easy non-probability sampling. The information of these patients was collected through a preliminary questionnaire and analyzed using SPSS 16 software. Results: In this study, the number of 535 participants were male and 496 were female. 53.5% of patients had non-bilious vomiting، 67.6% had normal abdominal function، 53% had anorexia، 16.2% had abdominal distension and 14.3% had fever. 20.1% had pain in the right lower quadrant، 16.1% no tenderness، 15.6% rebound tenderness، 5.4% guarding، 5.8% psoas sign and 16.3% Murphy sign. 27% of abdominal pain was related to appendicitis، 20% to cholecystitis، 15.3% to intestinal obstruction and the lowest number of cases were related to metastasis and ectopic pregnancy with 0.3%. Conclusion: The best tools available for examining and managing abdominal pain are clinical examination and a comprehensive history.   5794 Dental Evaluation of Knowledge and Attitude of Dental Residents and Students of Shahid Sadoughi University of Medical Sciences towards the Need to Prescribe Cone Beam Computed Tomography (CBCT) in Years 2022-2023 Razavi Seyed Hossein Kabodsaz Yazdi Motahareh Namiranian Nasim Hajirafieiha Mina Hajirafieiha Mona Lesani Katayoun Department of Oral and Maxillofacial Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Oral and Maxillofacial Radiology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Farhangian Clinic, Qazvin, Iran. School of Dentistry, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 1 9 2023 31 6 6772 6780 13 07 2022 22 01 2023 Introduction: In recent years, CBCT imaging has found many applications in dentistry due to its advantages such as 3D images, ease of imaging and the possibility of data reconstruction. The aim of this study was to evaluate the knowledge and attitude of dental residents and students of Shahid Sadoughi University of Medical Sciences towards the need to prescribe CBCT in 2022-2023. Methods: the current study is a cross-sectional and descriptive study.146 general dentistry students and 24 dental residents participated in this study. 23 questions in the field of knowledge and attitude about the use of CBCT were used. The validity of the questionnaire was confirmed by using sources, valid scientific articles and by presenting and consulting radiology specialists. To determine the reliability, retest and Cronbach's alpha coefficient was used. Finally, the results were statistically analyzed by SPSS software version16 using chi-square, t-test and correlation tests. Results: The level of knowledge and attitude of general students was higher than dental residents. Moreover, there was a significant difference between the level of knowledge and attitude of students with their duration of study at the university, so the higher the academic year, the lower the knowledge and attitude. Conclusion: The results of the present study showed that dental students of Shahid Sadoughi University of Medical Sciences have a relatively moderate knowledge and attitude about the use of CBCT.   5903 Psychiatry Psychometric Properties of Persian Version of the Ottawa Self-Injury Inventory in Hospitalized Patients Valiollah Akbari Vahedian Mostafa Rahmatinejad Parvin Department of Psychiatry, Qom University of Medical Sciences, Qom, Iran. Department of Statistics and Epidemiology, Qom University of Medical Sciences, Qom, Iran. Nekoei-Hedayati Hospital, Qom University of Medical Sciences, Qom, Iran. 1 9 2023 31 6 6781 6791 26 12 2022 04 07 2023 Introduction: Non-Suicidal Self-Injury (NSSI) has high prevalence among the patients with psychiatric disorders. Self-Injury plays an important role in the treatment, prognosis and risk of suicide, which highlights the need for an appropriate tool to assess the nature and psychological functions of NSSI. Therefore, the aim of this study was to determine the psychometric properties of the Persian version of the Ottawa Self-Injury inventory (OSI) in hospitalized patients. Methods: The present study was a psychometric study based on analytical method. The research has been performed on 310 patients with non-suicidal self-injury who have been referred to Nekoei-Hedayati Hospital in Qom City. Sample group completed Persian version of the Ottawa Self-Injury inventory. Data were analyzed using SPSS-16 and Cronbach’s alpha coefficient, Content Validity Index (CVI) and Content Validity Ratio (CVR). Results: The results showed that content validity index in this study was more than 0.75 and content validity ratio for validity of questions was more than 0.79.   The impact score of all items (Except for the tenth question) was higher than 1.5 that confirmed the face validity of inventory. The total Cronbach's alpha coefficient was calculated 0.71. Another result of this study was that 52% of patients reported at least one addictive characteristic. Conclusion: The finding showed that Persian version of Ottawa Self-Injury inventory has appropriate validity (face /content) and reliability in the inpatient population.   5966 other Effect of Exercises in Water and Thera-Band on the Electrical Activity of Lower Limb Muscles in People with Pronated Foot During Walking: A Clinical Trial Study Piri Ebrahim Barghamadi Mohsen Farzizadeh Reza Department of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Department of Sports Biomechanics, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Department of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. 1 9 2023 31 6 6792 6804 06 04 2023 17 05 2023 Introduction: The ankle joint is one of the most vulnerable joints in the body due to weight bearing. Pronated foot is one of the most common complications of the lower limbs. Therefore, the aim of the present study was to investigate the effect of exercise protocol in water and theraband on the electrical activity of lower limb muscles in people with pronate foot during walking. Methods: The present research was a clinical trial study that was conducted in a semi-experimental and laboratory. The participants of the present study included 45 students of University of Mohaghegh Ardabili, Ardabil, Iran,  who had pronated foot. They were selected purposefully and divided into three equal groups. The age range of the subjects was 18-25 years. To measure the electrical activity muscles of lower limbs, it was recorded using an electromyography device. Electromyography data were analyzed using biometric datalite program. In addition, analysis of variance with repeated measurements and bonferroni post hoc test was used, and the significance level was P≤0.05. Results: The results showed that there was a significant difference between time*group activity of the gastrocnemius (P=0.001) and semitendinosus (P=0.046) in the three groups of training in water, theraband and control during the heel contact phase. Therefore, using the appropriate post hoc test (LSD), it was shown that the activity of the gastrocnemius muscle in the post-test compared to the pre-test in the group of training in water (P<0.001; d=6.08) and theraband (P<0.001; d=3.66) had a significant increase of 24.03 and 16.46%, respectively. The activity of the semitendinosus muscle in the post-test compared to the pre-test in the water training group (P=0.041; d=4.98) and theraband (P=0.048; d=4.76) had a significant increase of 21.06 and 19.01%, respectively. Conclusion: According to the present study, it seems that doing exercises in water and thera-band can play an effective role in improving the range of electrical activity of the muscles on lower limbs of people with pronated foot during walking. In addition, according to the effect size, it was found that training in water had a better effect on the activity of the gastrocnemius and semi tendinosus compared to thera-band.