20 2228-5741 Shahid Sadoughi University of Medical Sciences 4276 Epidemiology Prevalence of obesity among Iranian female university students (2001-2017): A systematic review and meta-analysis Mohammadi Masoud b b Department of Nursing, School of Nursing and Midwifery 1 2 2018 25 11 843 852 04 08 2017 02 12 2017 Abstract Introdution: The prevalence of obesity in the world has been rising and it has involved developing and developed countries. The study aimed to investigate the prevalence of obesity among Iranian female university students and the importance of preventing this problem through a systematic review and meta-analysis. Methods: The study was performed via meta-analysis method, and some relevant articles were obtained in scientific databases, including SID, Sciencedirect, PubMed and Google scholar. Reference lists of identified articles were reviewed for additional articles. Heterogeneity of the studies was checked using  index. Data were analyzed using the comprehensive meta-analysis (CMA) software. Results: By investigating 10 studied articles,the overall prevalence of obesity among female university students in Iran was 3 % (95% Cl 2.5%-3.6%) during 2001-2017. The highest prevalence of obesity was recorded in Tehran in 2005, 9.3% (95% Cl: 5.6%-15.1%) and the lowest prevalence of obesity was found in Ardebil in 2012, 1% (95% Cl: 0.4%-4%). Conclusion: According to the results of this study, the prevalence of obesity is not high in female students (3 %), but it is necessary to pay particular attention to information on obesity and girls' sports in universities, so that the prevalence of this disease is not increased.  
4560 Prevalence of obesity among Iranian female university students (2001-2017): A systematic review and meta-analysis Mohammadi Masoud c c Department of Nursing, School of Nursing and Midwifery 1 2 2018 25 11 843 852 20 05 2018 20 05 2018 Abstract Introdution: The prevalence of obesity in the world has been rising and it has involved developing and developed countries. The study aimed to investigate the prevalence of obesity among Iranian female university students and the importance of preventing this problem through a systematic review and meta-analysis. Methods: The study was performed via meta-analysis method, and some relevant articles were obtained in scientific databases, including SID, Sciencedirect, PubMed and Google scholar. Reference lists of identified articles were reviewed for additional articles. Heterogeneity of the studies was checked using  index. Data were analyzed using the comprehensive meta-analysis (CMA) software. Results: By investigating 10 studied articles,the overall prevalence of obesity among female university students in Iran was 3 % (95% Cl 2.5%-3.6%) during 2001-2017. The highest prevalence of obesity was recorded in Tehran in 2005, 9.3% (95% Cl: 5.6%-15.1%) and the lowest prevalence of obesity was found in Ardebil in 2012, 1% (95% Cl: 0.4%-4%). Conclusion: According to the results of this study, the prevalence of obesity is not high in female students (3 %), but it is necessary to pay particular attention to information on obesity and girls' sports in universities, so that the prevalence of this disease is not increased.   4312 Biology A new strategy in improving therapeutic indexes of medicinal herbs: preparation and characterization of nano-liposomes containing Mentha piperita essential oil Majdizadeh Mohammad d Rezaei Zarchi Saeed e Movahedpour Afsaneh Alsadat f Shahi Malmir Hashem g Sasani Elham h Haghiralsadat Bibi Fatemeh i d Department of Biology, Taft Payame Noor University, Yazd, Iran e Department of Biology, Taft Payame Noor University, Yazd, Iran f Department of Textile and Polymer, Islamic Azad University, Yazd, Iran g Microbial Biotechnology, Department of Biology, Nourdanesh Higher Education Institute, Meymeh, Esfehan, Iran h Department of Biology, Taft Payame Noor University, Yazd, Iran i Department of Advanced Medical Sciences and Technologies, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 1 2 2018 25 11 853 864 31 08 2017 04 11 2017 Introduction: Herbal Compound and their essential oils possess high antimicrobial, antioxidant, and anti-tumor properties, but conventional prescribing of them faces serious challenges. Liposomal nano-carrier is one of the common pharmaceutical strategies to overcome these challenges. In this study, slow-released liposomal system containing Mentha piperita’s essential oil was prepared in order to improve its antimicrobial, antioxidant and antitumor properties. Methods: Liposomal vesicles were prepared using phosphatidylcholine (80%) and cholesterol (20%) by thin-film method. Mentha piperita’s essential oil were loaded into the liposomes using inactive loading method. Their physico-chemical features were assayed using Zeta-Sizer, FTIR and SEM, and at the end, the essential oil release amount was calculated at 37° C. Results: Liposomal vesicles containing Mentha piperita’s essential oil showed the size of 247  13.39 nm, 61.38% ± 2.7 essential oil encapsulation efficiency, -34.54  0.74 mV of zeta potential and polydispersity index (PDI) of 0.32  .01. The prepared liposomal system presented essential oil controlled release and FTIR and SEM investigation showed no interaction between nanocarrier and the essential oil and the carriers have spherical structures. Conclusion: In the present study, Mentha piperita’s essential oil encapsulated in liposomal carriers and its physicochemical properties investigated. The results confrimed the slow-releasing ability of system and also showed that the anionic nanosystem increased the essential oil’s stability without any change in its chemical nature. Taken together, liposomal nanocarrier could be a potent and suitable carrier for the essential oil. 4244 Biochemistry The effect of combined Atorvastatin and zinc sulfate on serum level of insulin, glucose, and histology of pancreas in streptozotocin-induced diabetic rats Karampour-Qibchag zahra j Heidari Reza k j university urmia k university urmia 1 2 2018 25 11 865 877 01 07 2017 16 09 2017 Introduction: Diabetes is an abnormality in metabolism, which occurs because of hyperglycemia resulting from failure in insulin release, function, or both. This study was conducted to investigate the effect of combined atorvastatin and zinc on serum levels of glucose and insulin and morphology of pancreas in type 1 diabetic rats. Methods: In this experimental study, 40 female Wistar rats were randomly divided into five groups (n=8): normal control (NC), diabetic control (DC), diabetic rats treated with 20mg/kg atorvastatin (DA), 30mg/kg zinc oxide (DZ) and combination of each drug in half dose (DZA). Diabetes was induced by intraperitoneal injection of 60 mg/kg streptozotocin. One week after streptozotocin injection, animals were treated with gastric gavage daily for one month. At the end of the treatment, rats sacrificed and fasting blood samples were collected from cervical vein and serum levels of glucose and insulin were measured with commercial kits by spectrophotometery and elisa, respectively. The pancreas of rats were removed and fixed and after tissue processing stained with H&E for light microscopic investigations. At the end, the data were analyzed statistically by SPSS software, ANOVA and Tukey tests. Results: The results showed that zinc and atorvastatin  caused the decrease of blood sugar and increase of insulin, as well as the decrease of the complications of diabetes, such as damage to pancreatic tissue, and reducing the number and diameter of the pancreatic islets. The combined of zinc and atorvastatin followed the decreasing of the lower levels of diabetic complications,  caused the significant decreasing (p<0/05) of the blood sugar and increasing insulin. Conclusion: It seems that a combination of atorvastatin and zinc has synergistic benefits to control of the glucose levels and insulin as well as improving pancreatic islets 4296 Epidemiology The effect of climate and weather on the epidemiology of leishmaniasis in the city of Yazd (an ecological study) Barati Hadis l Mohammadi Masoud m Khosroabadi Ali Asghar n Barati Mohammad o Lotfi Mohammad Hassan p Tajfirouz Ali Akbar l Department of Public Health, Faculty of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran m Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran n Department of Public Health, Faculty of Health, Sabzevar University of Medical Sciences, Sabzevar, Iran o Infectious Disease Research Center, Aja University of Medical Sciences, Tehran, Iran p (Corresponding Author) : Department of Statistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Deputy of Health Affairs, Shahid Sadoughi University of Medical Sciences, Yazd, Iran 1 2 2018 25 11 878 886 20 08 2017 02 12 2017 Introduction: Leishmaniasis is a major health problem in Iran and it has a heavy economic burden on communities. Therefore, the aim of this study is to investigate the effects of climate on the prevalence and incidence of leishmaniasis in Yazd. Methods: This is an ecological study. Data was collected from health department of Yazd University of Medical Sciences during the years 2003-2007 by age and sex, monthly and information about climate factors on monthly and annual basis including temperature, Relative humidity of air, precipitation from the general weather office of Yazd city, the information was entered into SPSS 16 software and analyzed by descriptive statistics as well as Spearman correlation and time delay analysis and analyzed the relationship and correlation between the elements of the cluster and the occurrence Cutaneous Leishmaniasis was performed in Yazd city. Resultus: According to the findings of this study, the most reported cases of leishmaniasis in men aged 11 to 30 years with 561 (69.9%), and in women in the age group of 71 and over with 41 The case (66.1%) and the highest upward trend were 2004 to 2005, 2009 to 2012, and in the month of October. Conclusion: The results of this study indicate that there is a strong and positive relationship with relative humidity and precipitation, which can guide policymakers in the area of health policy in this province to control and more effective prevention measures. 4292 Physiology Anxiolytic and antidepressant effects of Basil (Ocimum basilicum L.) hydro-alcoholic extract in male rats exposed to chronic restraint stress Mostafapour Parisa Asle-Rousta Masoumeh Rahnema Mehdi Department of Animal Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran Department of Animal Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran Department of Animal Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran 1 2 2018 25 11 887 896 17 08 2017 04 11 2017 Introduction: Studies show that chronic stress can lead to anxiety and depression. Basil (Ocimum basilicum L.) has antioxidant, anti-inflammatory, anti-apoptotic, anti-diabetic and anti-nociceptive properties. The aim of this study was to investigate the effect of basil hydro-alcoholic extract on chronic restraint stress-induced anxiety and depression in male Wistar rats. Methods: In this experimental study, 48 rats were allocated to 6 groups including: Control, Basil200 and Basil400 (receiving doses 200, 400 mg/kg/bw of Basil extract during 21 days), Stress (restrained in restrainers for 6hours per day for 21 consecutive days), Stress-Basil200 and Stress-Basil400 (received Basil extract in addition to chronic immobility stress). At the end of this period, anxiety and depression were evaluated using elevated plus maze (EPM) and forced swimming test, respectively. Results: Results show that chronic immobility causes anxiety and depression like behaviors in rats. Taking both doses of the Basil extract led to significant increase in percentages of open arm entry and time spent in open arm in EPM test compared with Stress Group (P<0.05). The results of forced swimming test showed significant increase in latency time (p<0.05) and decrease in immobility time (p<0.05) in Stress-Basil groups compared with Stress group. Conclusion: It is concluded that the Basil hydro-alcoholic extract, reduced anxiety and depression like behaviors in rats exposed to chronic restraint stress. 4234 Oncology Common malignancies in children (under 18 years) and its affected factors in Hamedan Province during 1386 to 1395 Eghbalian Mostafa Amiri Sasan Roshanaei Ghodratollah Esfahani Hossain Ahmadi Mohsen Assadi Sajadi Negar Hamadan University of Medical Sciences & Health Services, Hamadan, Iran Hamadan University of Medical Sciences & Health Services, Hamadan, Iran Modeling of Non-Communicable Diseases Research Center Hamadan University of Medical Sciences & Health Services, Hamadan, Iran Hamadan University of Medical Sciences, Hamadan, Iran Hamadan University of Medical Sciences, Hamadan, Iran Hamadan University of Medical Sciences & Health Services, Hamadan, Iran 1 2 2018 25 11 897 906 12 06 2017 16 09 2017 Introduction: Childhood cansers are the second leading cause of death among children. Since the incidence and prevalence of malignancies are different in different regions and there are several cultural and environmental factors involved, the aim of this study was investigating epidemiology of common malignancies in children in Hamedan Province during the years of 1386-1395. Methods: In this cross-sectional study, the population study was the children with  malignancies referred to Besat's Hospital in Hamadan Province. The collected data were analyzed using SPSS 20 software. Descriptive indices and Chi-square test were used in this study. Results: All available records showed that the malignancy was more prevalent in boys in freqency (57/7%). Most acute lymphoblastic leukemia (ALL) patients were 1-9 years, most acute myeloid leukemia (AML) patients were older than 9 years and most other malignancies were 1-4 years and over 9 years. The number of blood platelets (PLT) and the white blood cells (WBC) of the majority of patients in other malignancies, respectively, were greater than 100,000 and less than 50,000. For acute lymphoblastic leukemia and acute myeloid leukemia patients, the number of PLT and WBC  were less than 100,000 and less than 50,000, respectively. The most clinical symptoms for acute lymphoblastic leukemia patients were fever and pale,  fever and bleeding for acute myeloid leukemia AML patients, and finally masses and fever for patients with other malignancies. Conclusion: Although the results of the family cancer were consistent with expected results concluded of similar studies, but  the incidence of other malignancies in females was different (51/1%) with the results of some other studies. 4355 Physiology Effect of co-administration of lovastatin and folic acid on cognitive impairment due to bilateral electrical lesion of nucleus basalis magnocellularis in the Alzheimer's disease model in adult male rats Eskandary Azade Moazedi Ahmad Ali PhD student, Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran Professor, Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran 1 2 2018 25 11 907 920 14 10 2017 02 12 2017 Introduvtion: Alzheimer's disease is one of the most common neurodegenerative diseases in the brain. The aim of this study was to evaluate the effect of lovastatin and folic acid on cognitive deficit by induced lesion in nucleus basalis magnocellularis Methods: In this experimental study, 56 male Wistar rats were randomly divided into 8 groups: (7 rat in each group): control(intact), Nucleus basalis magnocellularis (NBM) lesion group, which received electrically- induced lesion (0.5 m A, 3s) in NBM, Sham group ( the electrode was impaled in to the NBM with no lesion), lovastatin group (NBM lesion + lovastatin 1mg/kg), folic acid group (NBM lesion+ folic acid 5mg/kg), interaction group( NBM lesion+ lovastatin-folic acid), saline group( NBM lesion + saline) and Dimethyl sulfoxide (DMSO) group (NBM lesion + DMSO 5%). Acquisition and retention testing was done by using an eight-radial arm maze, in which, the patterns of arm entries in each group for calculating working memory errors, reference memory error and latency were recorded. Data were analyzed using one-way ANOVA and Tukey's post hoc test Results: Results showed that there was a significant difference between the control and lesion groups in the parameters of the reference memory error, working memory error and elapsed time (P˂ 0.05). Co-administration of  lovastatin - folic acid resulted in a reduction in the reference and working memory error and the time spent in the eight-arm radial laser maze compared with lesion group Conclusion: According to the results, co-administration of folic acid and lovastatin had a positive effect on spatial memory of Alzheimer's rats. 4180 Epidemiology Investigating the methodology of indexed articles in breast cancer, ovarian cancer, colon and rectal cancer in SID and MEDLIB databases within 2004-2014 Nemati-anaraki Leila Momeni Esmat Shadfar vida Mostaghaci Mehrdad , Iran University of Medical Sciences Faculty of Psychology & Education of Allameh Tabataba`i University, Tehran, Iran. , Faculty of Humanities, Islamic Azad University, North Tehran Branch, Tehran, Iran. Shahid Sadoughi University of Medical Sciences,yazd,Iran 1 2 2018 25 11 921 930 29 04 2017 16 09 2017 Introduction: Methodology is one of the main parts of a study, indicating its scientific status. The aim of this study was to review the methodology of indexed articles in three domains, including breast, ovarian, colon and rectal cancers in SID and MEDLIB databases from 2004 until 2014. Method: The study was a descriptive cross-sectional one. It was used a checklist for gathering the required data. The articles consisted of 748 ones indexed in SID and MEDLIB databases in the domains of breast cancer, ovarian cancer, colon and rectal cancers since 2004 until 2014. The sample size was determined through stratified sampling as 188 articles. The data were analyzed by SPSS software version 21 and descriptive method, including table and chart, frequency and mean percentage. Results: Most of the articles (%89) belonged to SID database and related to breast cancer (%80. 9). All indexed articles were applied ones and %44.4 of them was written for the purpose of curing diseases. The most important method was the observation method (%69.4). The observation-analysis method was applied the most (%53.5). Among intervention studies, the most important method was empirical method (%88.1). Conclusion: According to the results of this study, it is necessary to pay special attention to various research methods of Persian researches related to above mentioned research fields in order to resolve the need of other researchers and medical teams can easily access these studies.