The Journal of Shahid Sadoughi University of Medical Sciences
مجله علمي پژوهشي دانشگاه علوم پزشكي شهید صدوقی يزد
JSSU
Medical Sciences
http://jssu.ssu.ac.ir
20
journal20
2228-5741
2228-5733
fa
jalali
1404
5
1
gregorian
2025
8
1
33
5
online
1
fulltext
fa
تاثیر تمرینات هوازی بر نشانگرهای التهابی در بیماران پارکینسون: یک مرور سیستماتیک
Effect of Aerobic Training on Inflammatory Markers in Parkinson ’s Disease: A Systematic Review
فیزیولوژی ورزش
Exercise Physiology
مروری
Review article
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بیماری پارکینسون (</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">PD</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) یکی از اختلال</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">های رایج تحلیل برنده عصبی می</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">باشد که تغییرات پاتولوژیک ناشی از آن ناحیه</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ای در مغز به نام ماده سیاه پارس کامپکتا (</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">SNpc</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) را تحت تأثیر قرار می</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">دهد که سرشار از نورون</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">های دوپامینرژیک است. یکی از محتمل</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ترین عوامل ایجاد بیماری پارکینسون تجمع آلفا سینوکلئین و به دنبال آن فعال</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">شدن میکروگلیا و آستروسیت</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ها است که منجر به التهاب عصبی مزمن می</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">شود. هدف مطالعه مروری اخیر بررسی آثار تمرینات ورزشی هوازی بر تعدیل التهاب در بیماری پارکینسون است.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش بررسی:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در این مقاله مروری سیستماتیک، پژوهش</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">های انجام گرفته در زمینه اثر تمرینات ورزشی مختلف بر نشانگرهای التهابی در بیماری پارکینسون مدل انسانی و حیوانی مورد بررسی قرار گرفت. برای دسترسی به مقالات علمی از پایگاه</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">های اطلاعاتی </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Pubmed</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Springer</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Hindawi</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Scopus</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Google Scholar</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">SID</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">MagIran</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و از کلید واژه</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">های </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Parkinson’s disease</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Aerobic training</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Endurance training</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Neuroinflammation</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Cytokine inflammatory</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> استفاده شد. از بین 962 مطالعه مورد بررسی در 15 سال اخیر، 15 مطالعه شرایط موردنظر را داشتند.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج نشان داد که تمرین هوازی اعم از تداومی و تناوبی در کاهش نشانگرهای التهابی بیماری پارکینسون به</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ویژه در مدل حیوانی موثر است، گرچه در مورد مقایسه انواع مختلف این نوع تمرین ورزشی مثل تداومی و تناوبی مطالعات چندانی صورت نگرفته و به مطالعات بیشتری در این زمینه نیاز هست.</span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتیجهگیری:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تمرین هوازی روش مفیدی در تعدیل التهاب بیماری پارکینسون باشد و می</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تواند به عنوان رویکردی غیردارویی در بهبود عوارض این بیماری باشد.</span></span></span></span></span></span></span><br>
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<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Introduction:</span></span></b> <span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Parkinson’s disease (PD) is a prevalent neurodegenerative disorders characterized by pathological changes in an area of the brain known as the substantia nigra pars compacta (SNpc), which contains a high density of dopaminergic neurons. A key factor that probably contributes to the development of Parkinson’s disease is the accumulation of alpha-synuclein, followed by the activation of microglia and astrocytes, leading to chronic neuroinflammation. The aim of the recent review study was to investigate the effects of aerobic exercise on modulating inflammation in Parkinson’s disease.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Methods:</span></span></b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt"> This systematic review analyzed research on the effects of various exercise routines on inflammatory markers in both human and animal models of Parkinson’s disease. Scientific articles were accessed using databases such as Pubmed, Springer, Hindawi, Scopus, Google Scholar, SID, and Mag Iran, with keywords, including Parkinson’s disease, aerobic exercise, neuroinflammation, and inflammatory cytokines. Out of 962 studies analyzed in the last 15 years, 15 studies met the inclusion criteria.</span></span><b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt"></span></span></b></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Results:</span></span></b><b> </b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">The results indicated that aerobic exercise, encompassing both continuous and interval workouts effectively lowered inflammatory markers in Parkinson’s disease, particularly in animal models. Nonetheless, there have been few studies comparing different forms of aerobic exercise, like continuous and interval training, highlighting a need for further research in this field.</span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Conclusion:</span></span></b><b> </b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Aerobic exercise might be a beneficial method to manage inflammation in Parkinson’s disease and can serve as a non-pharmacological approach to enhance the issues associated with this condition.</span></span></span></span></span><br>
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بیماری پارکینسون, التهاب, تمرین هوازی, سایتوکین التهابی
Parkinson’s Disease, Inflammation, Aerobic Exercise, Inflammatory Cytokine.
9003
9013
http://jssu.ssu.ac.ir/browse.php?a_code=A-10-4570-5&slc_lang=fa&sid=1
Somayeh
Bakhtiari Dehbalaei
سمیه
بختیاری ده بالایی
mahgoljan1399@gmail.com