The Journal of Shahid Sadoughi University of Medical Sciences
مجله علمي پژوهشي دانشگاه علوم پزشكي شهید صدوقی يزد
JSSU
Medical Sciences
http://jssu.ssu.ac.ir
20
journal20
2228-5741
2228-5733
fa
jalali
1404
11
1
gregorian
2026
2
1
33
10
online
1
fulltext
fa
اثر دو نوع تمرین مقاومتی با و بدون محدودیت جریان خون بر برخی سایتوکاین های پیش التهابی در مردان دارای اضافه وزن
Effect of Two Types of Resistance Training with and Without Blood Flow Restriction on Some Pro-Inflammatory Cytokines in Overweight Men
فیزیولوژی ورزش
Exercise Physiology
پژوهشي
Original article
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">سیتوکینها گروهی از پروتئینها هستند که نقش اصلی را در پاسخهای التهابی به محرکهای پاتولوژی مانند التهاب و بهبود سلامت متابولیک در افراد دارای اضافهوزن ایفا کنند. هدف از تحقیق حاضر، اثر دو نوع تمرین مقاومتی با و بدون محدودیت جریان خون بر برخی سایتوکاینهای پیشالتهابی در مردان دارای اضافهوزنبود.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش بررسی:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش پژوهش حاضر از نوع مداخلهای (نیمه تجربی) بود. 50 مرد با میانگین سنی 1/98</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">±</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">25/66 سال و شاخص توده بدنی 3/34</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">±</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">28/1 کیلوگرم بر مترمربع انتخاب شدند و بهصورت تصادفی در 5 گروه تمرین مقاومتی 1 (10 نفر)، تمرین مقاومتی 2 (10 نفر)، تمرین مقاومتی 1 با محدودیت جریان خون(10 نفر)، تمرین مقاومتی 2 با محدودیت جریان خون (10 نفر) و کنترل (10 نفر) تقسیم شدند. تمرینات مقاومتی 1 و 2 با و بدون محدودیت جریان به مدت 6 هفته و هر هفته 3 جلسه انجام شد. قبل و بعد از شش هفته تمرین، نمونههای خونی آزمودنیها جمعآوری و سطوح سرمی </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TNF-a</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">IL-1 β</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">IL-6</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> با روش الایزا اندازهگیری شد. سپس تغییرات برونگروهی با آزمون کواریانس و درون گروهی بونفرونی </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">با نرمافزار </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">SPSS version 16</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">ارزبابی قرار گرفت.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج نشان داد که اختلاف معنیداری بین 5 گروه پژوهش در سطوح </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TNF-α</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">IL-6</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">(000</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">/</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">0</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) وجود دارد و تغییرات سطوح </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">TNF-α</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> در گروههای تمرین مقاومتی 1 (003</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">/</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">0</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) ، تمرین مقاومتی 2 (0/004 =</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) ، تمرین مقاومتی1 و 2 با محدودیت جریان خون (000</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">/</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">0</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) نسبت به گروه کنترل کاهش معنیداری داشت و تغییرات سطوح </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">IL-6</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> نیز در گروههای تمرین مقاومتی با محدودیت جریان 1 و 2 نسبت به گروه کنترل کاهش معنیداری داشت (001</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">/</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">0</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) ، ضمن این که اختلاف معنیداری میان گروههای پژوهش در سطوح </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">IL-1 β</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (115</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">/</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">0</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) مشاهده نشد.</span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتیجهگیری:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مطالعه حاضر نشان داد که تمرین مقاومتی با و بدون محدودیت جریان خون میتوانند یک ابزار غیردارویی مفید برای کاهش برخی فاکتورهای التهابی مزمن محسوب شوند.</span></span></span></span></span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:17.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b> <span new="" roman="" style="font-family:" times="">Cytokines are a group of proteins essential for inflammatory responses to pathological stimuli such as inflammation and for improving metabolic health in overweight individuals. The purpose of this research was to determine the effect of two types of resistance training with and without blood flow restriction on some pro-inflammatory cytokines in overweight men.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:17.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b><span new="" roman="" style="font-family:" times=""> The present study was a semi-experimental interventional study. Fifty males with a mean age of 25.66±1.98 years and a body mass index of 28.1±3.34 kg/m2 were selected and randomly divided into 5 groups: resistance training 1 (n=10), resistance training 2 (n=10), resistance training 1 with blood flow restriction (n=10), resistance training 2 with blood flow restriction (n=10), and control groups (n=10). Resistance training 1 and 2, both with and without flow restriction, were performed for 6 weeks, 3 sessions per week. Before and after six weeks of training, blood samples were collected from the participants and serum levels of TNF-a, IL-1 β, and IL-6 were measured using ELISA. Subsequently, between-group changes were evaluated using the covariance test and within-group Bonferroni test.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:17.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><b> </b><span new="" roman="" style="font-family:" times="">The results showed a significant difference among the 5 research groups regarding TNF-α and IL-6 levels (P=0.000), and the changes in TNF-α levels in resistance training groups 1 (P=0.003), resistance training 2 (P=0.004), resistance training 1 and 2 with blood flow restriction (P=0.000) were significantly reduced compared to the control group. Additionally, the changes in IL-6 levels in resistance training groups 1 and 2 utilizing flow restriction were also significantly reduced compared to the control group (P=0.001), while no significant difference was observed between the research groups in IL-1 β levels.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:17.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><b> </b><span new="" roman="" style="font-family:" times="">Our study shows that resistance training with and without blood flow restriction can be a useful non-pharmacological tool to reduce some chronic inflammatory factors.</span></span></span></span><br>
</div>
تمرین مقاومتی با محدودیت جریان, اضافهوزن, TNF-a , IL-6 , IL-1 β
Resistance training with flow limitation, Overweight, TNF-a, IL-6, IL-1 β.
9540
9551
http://jssu.ssu.ac.ir/browse.php?a_code=A-10-60-9&slc_lang=fa&sid=1
Ali
Barzegari
علی
برزگری
ali_barzegari@pnu.ac.ir