The Journal of Shahid Sadoughi University of Medical Sciences
مجله علمي پژوهشي دانشگاه علوم پزشكي شهید صدوقی يزد
JSSU
Medical Sciences
http://jssu.ssu.ac.ir
20
journal20
2228-5741
2228-5733
fa
jalali
1403
4
1
gregorian
2024
7
1
32
4
online
1
fulltext
fa
تاثیر تمرینات ترکیبی بر هموستاز گلوکز و سطوح پلاسمایی سیرتوئین 1 و FOXO1 در مردان سالمند چاق
Effect of Combined Exercises on Glucose Homeostasis and Plasma Levels of Sirtuin 1 and FOXO1 in Obese Elderly Men
فیزیولوژی ورزش
Exercise Physiology
پژوهشي
Original article
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">پیری و چاقی علائم مشترکی از جمله تغییر در متابولیسم گلوکز و لیپید دارند. فعالسازی سیرتوئین 1 و </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">FOXO1</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">Forkhead Box Protein O1</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) میتواند بر اختلالات متابولیک مرتبط با افزایش سن و چاقی تأثیر مثبت بگذارد. هدف از تحقیق حاضر بررسی 16 هفته تمرین ترکیبی بر سطوح پلاسمایی سیرتوئین 1، </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">FOXO1</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و هموستاز گلوکز در سالمندان چاق است.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش بررسی:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تعداد 40 نفر از مردان سالمند چاق با میانگین سن 2/84 </span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">±</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> 61/90 انتخاب و بهصورت تصادفی در دو گروه تجربی و کنترل تقسیم شدند. آزمودنیها هفتهای سه روز (هر جلسه 90 دقیقه) به مدت 16 هفته تمرین کردند. 48 ساعت قبل و بعد از تمرین مشخصات آنتروپومتریک و مقادیر پلاسمایی سیرتوئین 1، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FOXO1</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، قند خون ناشتا، انسولین، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">HOMA-IR</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Homeostatic Model Assessment for Insulin Resistance</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">HOMA-B</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Homeostasis Model Assessment of β-Cell</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) از نمونهها اخذ و به روش الایزا اندازه گیری شد. تحلیل دادهها با استفاده از نرمافزار 16</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">version </span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">SPSS</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و آزمون آماری تی مستقل و وابسته در سطح معنیداری 0/05</span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">˂</span></span> <span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> انجام شد.</span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج:</span></span></b><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> مقادیر قند خون ناشتا (0/04=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">)، انسولین (0/008=</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) در گروه تجربی نسبت به گروه کنترل کاهش معنیداری یافت در حالیکه سطوح سرمی سیرتوئین1 (0/0001 =</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FOXO1</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (0/0001 =</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) افزایش معنیداری داشت. نتایج </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">t</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> همبسته در گروه تجربی نیز کاهش معنیدار در انسولین، </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">HOMA-IR</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">HOMA-B</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (0/001 =</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">P</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و افزایش معنیدار در سطوح سرمی سیرتوئین1 و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FOXO1 </span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (0/0001 =</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) را نشان داد (0/05 </span></span><span lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">˂</span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">p</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">).</span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<b><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتیجهگیری:</span></span></b> <span dir="RTL" lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">براساس نتایج این مطالعه به نظر میرسد که 16 هفته تمرین ترکیبی اثر مطلوبی بر بهبود هموستاز گلوکز، افزایش سطوح سیرتوئین 1 و </span></span><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FOXO1</span></span><span dir="RTL" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> مردان چاق سالمند دارد</span></span></div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b> <span new="" roman="" style="font-family:" times="">Aging and obesity have common symptoms, including glucose and lipid metabolism changes. Activation of sirtuin 1 and FOXO1 (Forkhead Box Protein O1) can positively affect metabolic disorders associated with aging and obesity. This research aimed to investigate 16 weeks of combined exercise on the plasma levels of sirtuin 1, FOXO1, and glucose homeostasis in obese elderly.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b> <span new="" roman="" style="font-family:" times="">40 obese elderly men with an average age of 61.90 ± 2.84 were selected and randomly divided into two experimental and control groups. The participants trained three days a week (each session 90 minutes) for 16 weeks. 48 hours before and after exercise, anthropometric characteristics and plasma values of sirtuin 1, FOXO1, fasting blood sugar, insulin, HOMA-IR</span> <span new="" roman="" style="font-family:" times="">(Homeostatic Model Assessment for Insulin Resistance), and HOMA-B (Homeostasis Model Assessment of β-Cell)</span> <span new="" roman="" style="font-family:" times="">were taken from the samples and measured by ELISA method. Data analysis was done using SPSS 16 software, independent and dependent t-tests at a significance level of P˂ 0.05.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><b> </b><span new="" roman="" style="font-family:" times="">Levels of fasting blood sugar (P=0.04), and insulin (P=0.008) in the experimental group decreased significantly compared to the control group, while the serum levels of sirtuin1 (P=0.0001) and FOXO1 (P=0.0001) had a significant increase. Correlated t results in the experimental group showed a significant decrease in insulin, HOMA-IR, and HOMA-B (P = 0.001) and a significant increase in the serum levels of sirtuin1 (P = 0.0001) and FOXO1 (P = 0.0001) (P ˂ 0.05).</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span> </b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">Based on the results of this study, it seems that 16 weeks of combined training has a favorable effect on improving glucose homeostasis, increasing sirtuin 1 and FOXO1 levels in elderly obese men.</span></span></div>
هموستاز گلوکز, سیرتوئین1, FOXO1, سالمندان چاق, تمرین ترکیبی
Glucose homeostasis, Sirtuin 1, FOXO1, Obese elderly, Combined exercise.
7754
7764
http://jssu.ssu.ac.ir/browse.php?a_code=A-10-5303-1&slc_lang=fa&sid=1
Maryam
Safari
مریم
صفری
marysafa.66402@gmail.com