The Journal of Shahid Sadoughi University of Medical Sciences
مجله علمي پژوهشي دانشگاه علوم پزشكي شهید صدوقی يزد
JSSU
Medical Sciences
http://jssu.ssu.ac.ir
20
journal20
2228-5741
2228-5733
fa
jalali
1403
5
1
gregorian
2024
8
1
32
5
online
1
fulltext
fa
سطح سرمی رزیستین در بیماران مبتلا به بیماری کبد چرب غیرالکلی در یک جمعیت ایرانی
Serum Resistin Levels in Patients with Nonalcoholic Fatty Liver Disease in an Iranian Population
بیوشیمی
Biochemistry
پژوهشي
Original article
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">بیماری کبدچربغیرالکلی (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">NAFLD</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) یکی از مشکلات اصلی سلامت جهانی است، در این بیماری چربی کبد از 5 درصد وزن کبدی فراتر میرود، بدون اینکه دلایل ثانویه تجمع چربی یا مصرف بیش از حد الکل وجود داشته باشد. </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">رزیستین نقش کلیدی </span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در هموستاز انرژی، مقاومت به انسولین، التهاب و اختلالات متابولیک دارد. این پژوهش با هدف بررسی ارتباط سطح رزیستین (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">RETN</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">NAFLD</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> انجام شد.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش بررسی:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در این مطالعه مقطعی تحلیلی 80 بیمار مبتلا به کبدچربغیرالکلی و 80 فرد سالم به عنوان کنترل، مورد بررسی قرار گرفتند. متغیرهای بیوشیمیایی، آنزیمهای کبدی، انسولین و رزیستین اندازهگیری شد. دادهها با نرمافزار</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">version 16 </span> <span dir="LTR" new="" roman="" style="font-family:" times="">SPSS</span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> مورد تجزیه و تحلیل قرار گرفت.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">متغیرهای </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">کلسترول، انسولین، تریگلیسرید، کلسترول لیپوپروتئین با چگالی بالا( </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HDL-C</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">)</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، نمایه توده بدنی، سن، </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">آنزیمهای کبدی </span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در دو گروه بیماران مبتلا به بیماری کبدچرب غیرالکلی و افراد سالم تفاوت معنیدارنشان دادند (0/05</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p<</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">). در افراد بیمار </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">رزیستین</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">با تریگلیسرید ارتباط نشان داد (0/045 </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p=</span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> ، 0/243-</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">r= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">).</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> ارتباطی بین سطح رزیستین با درجات کبدچرب یافت نشد</span></span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">(0/05</span></span><span lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">≤</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">).</span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتیجهگیری:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج این پژوهش نشان داد بین رزیستین و </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">NAFLD</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> رابطه وجود دارد. ارتباطی بین سطح رزیستین و درجه </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">NAFLD</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> وجود ندارد. </span></span></span></span></span></span></span></div>
<br>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b> <span new="" roman="" style="font-family:" times="">Non-alcoholic fatty liver disease (NAFLD) is a major global health problem, in which liver fat exceeds 5% of the liver weight, without secondary causes of fat accumulation or excessive alcohol consumption. Resistin plays a key role in energy homeostasis, insulin resistance, inflammation, and metabolic disorders. This study aimed to investigate the relationship between resistin (RETN) level and NAFLD.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b><span new="" roman="" style="font-family:" times=""> In this cross-sectional study, 80 patients with NAFLD and 80 healthy individuals as controls were evaluated. Biochemical variables, liver enzymes, insulin, and resistin were measured. Data were analyzed using SPSS version 16 software.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><b> </b><span new="" roman="" style="font-family:" times="">The variables of cholesterol, insulin, triglyceride, HDL, body mass index, age, and liver enzymes were significantly different between the two groups of patients with NAFLD and healthy individuals (p<0.05). In patients, resistin was associated with triglyceride (r=0.243, p=0.045). No association was found between resistin level and NAFLD grades (p≥0.05).</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><b> </b><span new="" roman="" style="font-family:" times="">The results of this study </span><span class="fontstyle01" style="font-family:" timesnewromanpsmt=""><span style="color:black"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">indicate </span></span></span></span></span></span><span new="" roman="" style="font-family:" times="">that </span><span class="fontstyle01" style="font-family:" timesnewromanpsmt=""><span style="color:black"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">there is</span></span></span></span></span></span> <span new="" roman="" style="font-family:" times="">a relationship</span><span class="fontstyle01" style="font-family:" timesnewromanpsmt=""><span style="color:black"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> between </span></span></span></span></span></span><span new="" roman="" style="font-family:" times="">resistin</span><span class="fontstyle01" style="font-family:" timesnewromanpsmt=""><span style="color:black"><span style="font-weight:normal"><span style="font-style:normal"><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> and </span></span></span></span></span></span><span new="" roman="" style="font-family:" times="">NAFLD. There is no association between resistin level and the degree of NAFLD.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
</div>
بیماری کبدچربغیرالکلی, رزیستین, تریگلیسرید, مقاومت به انسولین
Non-alcoholic fatty liver disease, Resistin, Triglyceride, Insulin Resistance.
7817
7826
http://jssu.ssu.ac.ir/browse.php?a_code=A-10-3652-3&slc_lang=fa&sid=1
Elahe
Davoudi
الهه
داوودی
elahedavoudi688@yahoo.com