The Journal of Shahid Sadoughi University of Medical Sciences
مجله علمي پژوهشي دانشگاه علوم پزشكي شهید صدوقی يزد
JSSU
Medical Sciences
http://jssu.ssu.ac.ir
20
journal20
2228-5741
2228-5733
fa
jalali
1402
8
1
gregorian
2023
11
1
31
8
online
1
fulltext
fa
اثر تمرین شنا بر فاکتورهای مورفولوژیک قلبی، آپلین و فاکتور رشد شبه انسولینی-1 رتهای ویستار نر
Effect of Swimming Training on Cardiac Morphological Factors, Apelin and Insulin like Growth Factor-1 in Male Wistar Rats
فیزیولوژی ورزش
Exercise Physiology
پژوهشي
Original article
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">اثرات محافظتی فعالیت بدنی بر قلب در پژوهشهای پیشین مورد مطالعه قرار گرفته است. با این وجود، نیاز به بررسی بیشتر مکانیزمهای محافظتی احساس میشود. مطالعه حاضر به بررسی اثرات محافظتی شنای تداومی و تناوبی بر فاکتورهای مورفولوژیک قلبی، آپلین و فاکتور شبه انسولینی-1 رتهای ویستار پرداخت.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش بررسی:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در این مطالعه تجربی، 27 سر موش نر ویستار </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">در گروه کنترل (6</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">n=</span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">)، شَم (5</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">n=</span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">)، تمرین تداومی (8</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">n=</span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و تناوبی (8</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">n=</span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) بهطور تصادفی قرار گرفتند. در این تمرین 12 هفتهای، گروه تداومی 5 روز در هفته با افزایش مدت شنا و گروه تناوبی </span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">4 روز در هفته با </span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">افزایش وزنه تمرین نمودند. وزن قلب و بطن چپ،</span></span> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">فاکتور شبه انسولینی-1 و آپلین اندازهگیری شدند. دادهها با تحلیل واریانس یک سویه و آزمون توکی در سطح 0/05 در نرمافزار</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">version 16 </span> <span dir="LTR" new="" roman="" style="font-family:" times="">SPSS</span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> تحلیل گردید.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">وزن کل قلب در گروههای تداومی و تناوبی بهطور معناداری بیشتر از گروه شَم (0/02</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، 0/02</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و کنترل (0/02</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، 0/02</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) بود. وزن بطن چپ در گروه تداومی نسبت به دو گروه شَم (0/03</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و کنترل ( 0/01</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">)؛ و گروه تناوبی با کنترل (0/01</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) بالاتر بود. غلظت آپلین در گروه کنترل با تناوبی و تداومی (0/00</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و0/02</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و شَم با تناوبی و تداومی (0/02</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و0/04</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) تفاوت معنادار داشت. فاکتور شبه انسولینی-1 نیز در گروه کنترل با تناوبی و تداومی تفاوت معنادار داشت (0/01</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و0/01</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">P= </span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">).</span></span> <span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتیجهگیری:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">به نظر میرسد تمرین شنای تناوبی و تداومی با تنظیم فاکتور شبه انسولینی-1 و آپلین اثر مثبتی بر حفاظت قلبی داشته و سبب هایپرتروفی فیزیولوژیک قلب میشوند.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
</div>
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:15.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b> <span new="" roman="" style="font-family:" times="">Different training methods have cardioprotective effects. The aim of this study was to examine the potential protective impact of continuous and interval swimming training with weights on cardiac morphological factors and serum levels of Apelin and Insulin-like Growth Factor-1 in male Wistar rats. </span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:15.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b> <span new="" roman="" style="font-family:" times="">In this experimental study, 27 male rats divided randomly into the control (n=6), sham (n=5), interval (n=8) and endurance (n=8) groups. The endurance group swam for 12 weeks/5 days while swimming time increased incrementally. During the 12-week/4-day period, the interval group engaged in swimming exercises while gradually increasing the load and reducing the duration of rest. Apelin and Insulin like Growth Factor-1 concentration, heart weight and left ventricle weight were measured. One-way ANOVA</span> <span new="" roman="" style="font-family:" times="">was utilized and Tuckey-HSD test was used to point out the place of significance (α ≤ 0.05).</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:15.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><b> </b><span new="" roman="" style="font-family:" times="">Findings showed that total heart weight in interval and endurance training compared to the control (P= 0.02 and P= 0.02 respectively) and sham (P= 0.02 and P= 0.02, respectively) significantly increased. Furthermore, the weight of the left ventricle showed a significant increase following endurance training in comparison to both the control (P= 0.02) and the sham groups (P= 0.02). Additionally, it was found to be significantly higher than the sham group following interval training. (P= 0.01). Apelin significantly increased in interval and endurance training compared to the control (P= 0.00 and P= 002 respectively) and sham groups (P= 0.02 and P= 0.04, respectively). Moreover, insulin like growth factor-1 significantly increased in interval and endurance training compared to the control (P= 0.01 and P= 0.01, respectively).</span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:15.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><b> </b><span new="" roman="" style="font-family:" times="">It appears that a 12-week swimming training program, particularly in an interval format, can induce physiological hypertrophy in cardiac tissue and provide cardiac protective benefits through the upregulation of Insulin-like Growth Factor-1 and Apelin. </span> </span></span><br>
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<span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:">Corresponding Author: </span></span></span></span><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">Mohammad Ali Gharaat</span></span></b><br>
<span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri="" style="font-family:"><a href="https://orcid.org/0000-0002-2923-9213">View Orcid in Profile</a><br>
You can search for this author in<span arial="" dir="RTL" style="font-family:"> <a href="http://pubmed.ncbi.nlm.nih.gov/?term=%28Mohammad+Ali+Gharaat%5BAuthor%5D%29+AND+%28Farhangian+University%2CTehran%5BAffiliation%5D%29&sort="><span calibri="" dir="LTR" lang="EN-US" style="font-family:">PubMed</span></a> </span>Google Scholar Profile</span></span></span></span><br>
</div>
فعالیت بدنی, بافت قلب, محافظت قلبی, آپلین, فاکتور رشد شبه انسولینی-1
Physical training, cardiac tissue, Cardioprotective effects, apelin, Insulin like growth factor-1.
6944
6954
http://jssu.ssu.ac.ir/browse.php?a_code=A-10-3342-3&slc_lang=fa&sid=1
Mohammad Ali
Gharaat
محمدعلی
قرائت
mohammadaligharaat@gmail.com