The Journal of Shahid Sadoughi University of Medical Sciences
مجله علمي پژوهشي دانشگاه علوم پزشكي شهید صدوقی يزد
JSSU
Medical Sciences
http://jssu.ssu.ac.ir
20
journal20
2228-5741
2228-5733
fa
jalali
1402
3
1
gregorian
2023
6
1
31
3
online
1
fulltext
fa
تاثیر تمرینات تناوبی شدید همراه با مصرف عصاره خرفه بر سطح FGF-21 و مقاومت به انسولین موشهای مبتلا به کبد چرب غیر الکلی (NAFLD)
Effect of High-Intensity Interval Training and Portulaca Oleracea Extract Supplementation on FGF-21 Level and Insulin Resistance in Rats with Non-Alcoholic Fatty Liver Disease
فیزیولوژی ورزش
Exercise Physiology
پژوهشي
Original article
<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه: </span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">هدف از تحقیق حاضر بررسی تأثیر تمرین تناوبی شدید (</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) همراه با مکملگیری عصاره خرفه بر سطح </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">FGF-21</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> کبدی و مقاومت به انسولین در موش­های صحرایی نر مبتلا به </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">NAFLD</span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> میباشد.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش بررسی: </span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">تعداد 20 رت نر بالغ نژاد ویستار باسن شش هفته با وزن 160 تا 185 گرم در 4 گروه شامل کنترل کبدچرب، </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">، عصاره و </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">+عصاره قرار داده شدند. با توجه به وزن موشها مکمل خرفه با دوز </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">mg/kg</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> 400 به دو گروه مربوطه خورانده شد. پروتکل تمرین </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> به مدت 8 هفته، 5 جلسه در هفته و هر جلسه باشدت 80 تا ۹۰ درصد سرعت بیشینه انجام شد. سطح </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">FGF-21</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> کبدی و مقاومت به انسولین بعد از 8 هفته تمرین </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و مصرف عصاره خرفه اندازهگیری شد. از آنالیز واریانس یک طرفه و آزمون تعقیبی توکی برای مقایسه گروه­ها در سطح معناداری 0/05></span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> استفاده شد.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج:</span></span></b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> مقاومت به انسولین در گروه­های </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (0/01=</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">)، عصاره خرفه (0/037=</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">+عصاره (0/012=</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) بهطور معنیداری نسبت به گروه کبد چرب کنترل پایین­تر بود. سطح </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">FGF-21</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> کبدی در گروههای </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> (0/033=</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">)، عصاره خرفه (0/019=</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) و </span></span><span dir="LTR" new="" roman="" style="font-family:" times="">HIIT</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">+عصاره (0/023=</span></span><span dir="LTR" new="" roman="" style="font-family:" times="">p</span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">) نسبت به گروه کنترل کبد چرب بهطور معنی­داری بالاتر بود.</span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتیجهگیری:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">احتمالاً تمرین ورزشی به تنهایی و همراه با مکملگیری عصاره خرفه، از طریق بهبود سطح </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">FGF-21 </span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">و مقاومت به انسولین در بیماران مبتلا به </span></span><span dir="LTR" style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">NAFLD</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"> و میتواند نقش مهمی را در کنترل پیشرفت این بیماری برعهده داشته باشند.</span></span></span></span></span></span></span><br>
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<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b><span new="" roman="" style="font-family:" times=""> The aim of this study was to investigate the effect of eight weeks of high-intensity interval training (HIIT) and Portulaca Oleracea extract on FGF-21 levels and insulin resistance in rats with NAFLD</span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b><span new="" roman="" style="font-family:" times=""> Twenty male Wistar rats at six weeks old and 160 to 185 g weight were randomly divided into four groups: fatty liver control, HIIT, Portulaca Oleracea extract, and HIIT+Portulaca Oleracea extract. According to the weight of the mice, Portulaca Oleracea supplement with a dose of 400 mg/kg was given to the two respective groups. The HIIT training protocol was performed for 8 weeks, 5 sessions per week, and each session was performed at 80-90% of maximum speed. Hepatic FGF21 level and insulin resistance were measured after 8 weeks of HIIT training and consumption of purslane extract. One-way analysis of variance and Tukey's post hoc test were used to compare groups at a significance level of p<0.05. </span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Results: </span></span></b><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:-.1pt">Insulin resistance in HIIT (P=0.005), Portulaca Oleracea extract (P=0.011), and HIIT+Portulaca Oleracea extract (P=0.002) groups were significantly lower than fatty liver control group. The level of liver FGF-21 in the HIIT (p=0.023), Portulaca Oleracea extract (p=0.005) and HIIT+ Portulaca Oleracea extract (p=0.001) groups was significantly higher than the fatty liver control group</span></span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><span new="" roman="" style="font-family:" times=""> It seems that HIIT and Portulaca Oleracea extract could improve insulin resistance in NAFLD by increasing FGF-21 levels and can play an important role in controlling the progress of this disease</span><span dir="RTL" lang="AR-SA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">.</span></span><span style="font-family:"Times New Roman",serif"></span></span></span></span><br>
</div>
کبد چرب غیر الکلی, FGF-21, مقاومت به انسولین, HIIT, مکمل خرفه
HIIT, Portulaca Oleracea extract, FGF-21, Insulin resistance, Non-alcoholic fatty liver disease.
6480
6493
http://jssu.ssu.ac.ir/browse.php?a_code=A-10-4555-2&slc_lang=fa&sid=1
Mohammad
Ranaei
محمد
رعنایی
ranaei1950@yahoo.com