fa مقایسه سطح سرمی آدیپونکتین و کورتیزول در مردان مبتلا به اضافه‌وزن/چاقی و دارای وزن طبیعی بیوشیمی Biochemistry پژوهشي Original article <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">مقدمه:</span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">چاقی منجر به عوارض جدی مانند، دیابت نوع 2، بیماری کبد چرب غیر الکلی (</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">NAFLD</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">) و سندرم متابولیک می‌شود. سطح آدیپونکتین</span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> و کورتیزول</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> خون با چاقی ارتباط دارد. این مطالعه با هدف بررسی ارتباط سطح آدیپونکتین و کورتیزول با چاقی و پارامترهای بیوشیمیایی انجام شد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">روش بررسی:</span></span></b> <span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">این مطالعه مورد-شاهدی بر روی مردان، 80 شرکت‌کننده با 25</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">BMI&ge;</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> (شاخص توده بدنی) به عنوان گروه مورد و 100 شرکت‌کننده با 25</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">BMI<</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> به عنوان گروه شاهد، در پژوهشکده علوم غدد درون‌ریز دانشگاه علوم پزشکی شهید بهشتی انجام شد. سطح آدیپونکتین و کورتیزول پلاسما با کیت الایزا اندازه‌گیری شد و سایر متغیرها با روش‌های استاندارد تعیین شد. داده‌ها با استفاده از نسخه نرم‌افزار </span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">SPSS version 16</span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> مورد تجزیه و تحلیل قرار گرفت. 0/05</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">P<</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> معنی‌دار در نظر گرفته شد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتایج:</span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">یافته‌ها نشان داد که تفاوت معنی‌داری در سطح کورتیزول بین افراد با </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">25</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">BMI&ge;</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> و افراد با </span></span></span><span lang="FA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">25</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">BMI<</span></span> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">وجود ندارد. مردان چاق در مقایسه با گروه کنترل سطح بالاتری را در تری‌گلیسیرید، فشارخون سیستولیک و دیاستولیک و پروفایل لیپیدی داشتند در حالیکه سطح آدیپونکتین و </span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">HDL-C</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> (کلسترول لیپوپروتئین با چگالی بالا)کمتر بود (0/05<</span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">p</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">). در این مطالعه، ارتباط معکوس بین آدیپونکتین و </span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">FBS</span></span><span style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> (قند خون ناشتا) و </span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">BMI</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> مشاهده شد. ما ارتباط مثبت بین کورتیزول و کلسترول و </span></span></span><span dir="LTR" new="" roman="" style="font-family:" times=""><span style="color:black">FBS</span></span><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black"> یافتیم.</span></span></span><span dir="LTR" style="font-size:10.0pt"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:18.0pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:">نتیجه‌گیری:</span></span></b> <span lang="AR-SA" style="font-size:12.0pt"><span b="" nazanin="" style="font-family:"><span style="color:black">نتایج نشان داد ارتباطی بین کورتیزول و چاقی وجود ندارد، اما ارتباط منفی بین سطح آدیپونکتین با چاقی وجود دارد.</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="font-family:"B Nazanin""></span></span></span></span></span></span></span><br> &nbsp;</div> <div style="text-align: justify;"><br> <span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b> <span new="" roman="" style="font-family:" times="">Obesity, results in a number of serious complications, such as type 2 diabetes, non-<span style="color:black">alcoholic fatty liver disease and metabolic syndrome. The levels of blood of adiponectin and cortisol have been associated with obesity.</span></span><span new="" roman="" style="font-family:" times=""><span style="color:black"> This study aimed to investigate the relationship of adiponectin and cortisol levels with obesity and biochemical parameters.</span></span><span style="font-family:"Times New Roman","serif""></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Methods:</span></b> <span new="" roman="" style="font-family:" times=""><span style="color:black">This case-control study was conducted only on men, 80 participants with body mass index (BMI)&ge;25 considered as case group, and 100&nbsp;participants&nbsp;with BMI<25 as control group in the Research Institute for Endocrine Sciences,&nbsp;Shahid Beheshti University of Medical Sciences. Plasma levels of adiponectin and cortisol were measured through ELISA kit and&nbsp;other variables were determined&nbsp;by standard methods. Data were analyzed using&nbsp;SPSS software version 16. P-values <0.05 were considered as significant.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></b><span new="" roman="" style="font-family:" times=""><span style="color:black"> Our findings showed no significant difference in cortisol level between individuals with BMI&ge;25 and individuals with BMI<25. Obese men had significantly higher levels of triglycerides, systolic and diastolic blood pressure and lipid profiles whereas, adiponectin and high-density lipoprotein-cholesterol (HDL-C) levels were lower compared to the control group (p-value<0.05). In this study, an inverse correlation was observed between adiponectin and fasting blood glucose (FBS), and also BMI. It was&nbsp;found&nbsp;a&nbsp;positive correlation between cortisol and cholesterol and also FBS.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:18.0pt"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times=""><span style="color:black">Conclusion:</span></span></b><span new="" roman="" style="font-family:" times=""><span style="color:black"> The results show that there is no relationship between cortisol and obesity, but&nbsp;a&nbsp;negative correlation between&nbsp;adiponectin levels&nbsp;and&nbsp;obesity.</span></span></span></span></span><br> &nbsp;</div> آدیپونکتین, کورتیزول, چاقی, شاخص توده بدنی Adiponectin, Cortisol, Obesity, Body Mass Index. 5110 5119 http://jssu.ssu.ac.ir/browse.php?a_code=A-10-3652-2&slc_lang=fa&sid=1 Masoumeh Nezhadali معصومه نژادعلی ma_nejadali@yahoo.com 0000-0002-3931-9807 Yes Department of Biology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran. گروه زیست شناسی، واحد اسلامشهر، دانشگاه آزاد اسلامی، اسلامشهر، ایران.