fa بررسی شیوع پلی‌مورفیسم در ژن کد‌کننده آنزیم آروماتاز با خطر ابتلا به سرطان پروستات در شمال هندوستان خون و سرطان Oncology پژوهشي Original article <p align="justify" style="direction: rtl"> </p> <p dir="RTL"><strong>مقدمه: </strong>آخرین مرحله از مسیر بیوشیمیایی تولید هورمون استروژن، تولید آروماتاز می­باشد که یک آنزیم کلیدی برای سنتز این هورمون در مردان محسوب می­گردد. این آنزیم باعث تبدیل هورمون‌های آندروستندیون و تستوسترون به ترتیب به استرون و 17ß- استرادیول می‌گردد. یکی از مهمترین پلی‌مورفسیم‌ها در ژن 19<span dir="LTR">CYP</span>، تبدیل نوکلئوتید <span dir="LTR">C</span> به <span dir="LTR"> T</span>در اگزون 7 است که باعث تبدیل آمینواسید <span dir="LTR">Arg</span> به <span dir="LTR">Cys</span> در موقعیت 264 پروتئین آروماتاز می‌شود و این پلی مورفیسم در افراد آسیایی بسیار شایع است<span dir="LTR">.</span> هدف از این مطالعه، بررسی پلی‌مورفیسم 700519<span dir="LTR">rs </span> در مردان مبتلا به سرطان پروستات در جمعیت شمال هندوستان می‌باشد.</p> <p dir="RTL"><strong>روش بررسی:</strong> در این مطالعه که به روش مورد-شاهدی انجام شد، <span dir="LTR">DNA</span> استخراج شد و تکنیک <span dir="LTR">PCR-RFLP</span> برای آنالیز ژن<span dir="LTR">CYP19 </span> بر روی 100 بیمار مبتلا به سرطان پروستات مراجعه‌کنندگان به مرکز تحقیقاتی-پزشکی چندیگر، هندوستان و همان تعداد فرد سالم به عنوان کنترل  صورت گرفت. سپس داده‌ها توسط نرم‌افزار<span dir="LTR">SPSS</span> نسخه 19 مورد تجزیه و تحلیل قرار گرفت.</p> <p dir="RTL"><strong>نتایج:</strong> از لحاظ آماری ارتباط معناداری بین ژنوتیپ <span dir="LTR">CT</span> و خطر ابتلا به سرطان پروستات مشاهده شد<br> (012/0<span dir="LTR">p=</span>، 35/4-20/1، :95 <span dir="LTR">CI</span> درصد، 28/2<span dir="LTR">OR:</span>). ژنوتیپ <span dir="LTR">TT</span> با خطر ابتلا به سرطان پروستات در ارتباط نیست<br> (594/0<span dir="LTR">p=</span>، 53/2-19/0، 95 <span dir="LTR">CI</span> درصد، 70/0 :<span dir="LTR">OR</span>). همچنین ارتباط معنی‌داری بین مرحله و درجه بیماری با خطر ابتلا به سرطان پروستات در جمعیت مورد مطالعه مشاهده نشده است(05/0<span dir="LTR">p></span>).</p> <p dir="RTL"><strong>نتیجه‌گیری:</strong> به نظر می‌رسد که ژنوتیپ <span dir="LTR">CT</span> در مقایسه با سایر ژنوتیپ‌ها بیشتر با سرطان پروستات در ارتباط است. افزایش خطر ابتلا به سرطان پروستات با جایگزینی <span dir="LTR">Arg264Cys</span> در ژن <span dir="LTR">CYP19</span> مرتبط می‌باشد.</p> <p dir="RTL"> </p> <p align="justify" style="direction: rtl"> </p> <p align="justify" style="direction: rtl"> </p> <p dir="rtl" style="margin: 0cm 0.3pt 0pt 0cm text-align: justify line-height: normal unicode-bidi: embed direction: rtl"> </p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"> </p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><strong> </strong><font face="Times New Roman" size="3"> </font></font></font></p> <p dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><span><b><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">زمینه وهدف</span></b></span><span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">: مجموعه ای از</span></span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> <font size="3">واکنش های بیوشیمیایی</font> <font size="3">در</font> <font size="3">تولید</font> </span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">هورمون</span></span><span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> استروژن</span></span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-bidi-language:="" mso-hansi-font-family:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> <font size="3">نقش دارد.</font> </span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">هورمون های استروئیدی (استروژن ها و آندروژن ها)</span></span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> <font size="3">نقش بسزایی در ایجاد</font> <font size="3">سرطان</font> <font size="3">پروستات</font> <font size="3">نقش بازی می کنند. سیتوکروم </font></span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: ">p450</span></font><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span> یا پروتئین آروماتاز موجب تبدیل هورمون های آندروستندیون، تستوسترون و 16</span></span><span><span font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">&alpha</span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">- هیدروکسی تستوسترون، به استرون و 17</span></span><span><span font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">ß</span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">- استرادیول که همگی ساختار پایه استروژنی دارند، می گردد ژن </span></span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: ">CYP19 </span></font><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span style="mso-spacerun: yes"><font color="#222222" face="B Nazanin" size="3"> </font></span><span>پروتئین آروماتاز را کد می کند که آنزیمی کلیدی برای بیوسنتز استروژن می باشد</span></span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: ">.</span></font><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span> چندین</span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> </span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">پلی مورفیسم</span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> </span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">در</span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> </span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">ژن</span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> </span></span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: ">CYP19</span></font><span b="" font-size:="" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span> </span></span><span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: ">یافت شده است که یکی از آن ها تبدیل شدن نوکلئوتید </span></span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: ">C</span></font><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span> به </span></span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: "><span style="mso-spacerun: yes"><font color="#222222" size="3"> </font></span>T</span></font><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span>در اگزون 7 می­باشد که</span></span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> باعث تبدیل آمینواسید </span><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: "><font face="Calibri">Arg</font></span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> به آمینواسید </span><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: "><font face="Calibri">Cys</font></span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> در موقعیت 264 پروتئین آروماتاز می شود</span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: ">.</span></font><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span> هدف از مطالعه حاضر بررسی پلی مورفیسم </span></span><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: "><font face="Calibri">rs700519</font></span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> در مردان با سرطان پروستات می باشد. این پلی مورفیسم در اگزون 7 پروتئین آروماتاز قرار دارد و باعث تبدیل آمینواسید </span><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: "><font face="Calibri">Arg</font></span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> در موقعیت 264 به آمینواسید </span><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: "><font face="Calibri">Cys</font></span><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "> می شود.</span></font></font></p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><font face="Times New Roman" size="3"> </font></font></font></p> <p dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><b><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">روش بررسی:</span></b><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> تکنیک </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">PCR-RFLP</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> برای آنالیز ژن</span><font face="Calibri"><span b="" dir="ltr" style="color: rgb(34, 34, 34) line-height: 150% font-size: 12pt mso-bidi-language: FA mso-bidi-font-family: ">CYP19 </span></font><span b="" font-size:="" lang="FA" mso-bidi-language:="" style="color: rgb(34, 34, 34) line-height: 150% font-family: "><span style="mso-spacerun: yes"><font color="#222222" face="B Nazanin" size="3"> </font></span><span>بر روی </span></span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">100 بیمار مبتلا به سرطان پروستات و همان تعداد فرد سالم به عنوان گروه کنترل صورت گرفت. <span style="mso-spacerun: yes"><font color="#222222" face="B Nazanin" size="3"> </font></span>آنالیز اطلاعات توسط نرم افزار</span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">SPSS (version 19) </span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""><span style="mso-spacerun: yes"><font color="#222222" face="B Nazanin" size="3"> </font></span>مورد تجزیه و تحلیل قرار گرفت.</span></font></font></p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><font face="Times New Roman" size="3"> </font></font></font></p> <p dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><b><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">یافته­ها:</span></b><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times=""> فراوانی</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">ژنوتیپ</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">CT</span><span b="" font-size:="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">در بیماران</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">(</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">37٪) </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">در مقایسه با</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">گروه شاهد</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">(</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">21.2٪) </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">بالاتر و</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">این</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">نتیجه</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">آماری معنی دار بود</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">(</span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">OR</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">2.10</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">95٪ </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">CI</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">1.02-4.34</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">؛ </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">0.044</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">= </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">P</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">).</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">طبقه بندی</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">بیماران</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">با توجه به</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">عوامل خطر</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">منجر به بهبود اندک </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">OR</span><span b="" font-size:="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">در</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">افراد</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">حامل ژنوتیپ</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">CT</span><span b="" font-size:="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">نسبت به</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">ژنوتیپ</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">CC</span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""><span style="mso-spacerun: yes"><font color="#222222" face="B Nazanin" size="3"> </font></span>می شود </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">(</span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">OR</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">2.35</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">95٪ </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">CI</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">،</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">1.11-4.96</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">P = 0.024</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">)</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">. ژنوتیپ </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">TT</span><span b="" font-size:="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">از لحاظ معنی داری</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">با</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">خطر ابتلا به سرطان</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">پروستات</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">در ارتباط نیست</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">(</span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">OR</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">0.63</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">95٪ </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">CI</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">، </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">0.16-2.50</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">؛ </span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">0.519</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">P =</span><span b="" font-size:="" lang="AR-SA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="line-height: 150% font-family: " times="">).</span></font></font></p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><font face="Times New Roman" size="3"> </font></font></font></p> <p dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><b><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">نتیجه گیری</span></b><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">: به نظر می رسد که ژنوتیپ </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">CT</span><span b="" font-size:="" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> <span lang="FA"><font color="#222222" face="B Nazanin" size="3">در مقایسه با سایر ژنوتیپ­ها بیشتر با سرطان پروستات در ارتباط است. این چنین به نظر می رسد افزایش خطر ابتلا به سرطان پروستات با جایگزینی </font></span></span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">Arg264Cys</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> در ژن </span><span b="" dir="ltr" font-size:="" mso-ascii-theme-font:="" mso-bidi-font-family:="" mso-bidi-language:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times="">CYP19</span><span b="" font-size:="" lang="FA" mso-ascii-font-family:="" mso-ascii-theme-font:="" mso-bidi-language:="" mso-hansi-font-family:="" mso-hansi-theme-font:="" new="" style="color: rgb(34, 34, 34) line-height: 150% font-family: " times=""> در ارتباط می باشد.</span></font></font></p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"><font face="Times New Roman" size="3"><font color="#000000" face="tahoma,arial,helvetica,sans-serif"><font face="Times New Roman" size="3"> </font></font></font></p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"> </p> <p align="justify" dir="rtl" style="margin: 0cm 0.2pt 10pt 0cm text-align: justify line-height: 150% unicode-bidi: embed direction: rtl"> </p> <p align="left" style="direction: rtl"><font face="Times New Roman" size="3"> </font></p> <p align="left" style="direction: rtl"> </p> <p style="text-align: left">Background: A series of biochemical reactions are involved in the endogenous production of estrogens. Their final and rate-limiting step is catalyzed by aromatase belonging to the class XIX of cytochrome P450. CYP19 is a key enzyme for estrogen synthesis in males. It catalyzes the irreversible conversion of androstenedione and testosterone to estrone and estradiol-17&beta, respectively. Aromatase P450 is present in the endoplasmic reticulum of estrogen-reproducing cells in which it is expressed. The effects of the resulting estrogens are mediated through the estrogen receptor. One of the most important polymorphism, is a C to T variation in exon 7 resulting in an Arg264Cys amino acid exchange, has been shown to be very common in Asia. The purpose of this study was to determine the association of CYP19 gene polymorphism with the prostate cancer risk among the studied population. Methods: PCR-RFLP analysis of CYP19 gene was on 100 prostate cancer patients and an equal number of matching controls. The data was analyzed using the computer software SPSS for windows (version 19). Results: The frequency of CT genotype was higher in patients (37%) as compared to controls (21.2%) and this incidence was statistically significant (OR, 2.10 95 % CI, 1.02-4.34 P=0.044). Stratification of patients according to the risk factors, resulted in a slightly improved OR in individuals carrying CT compared to CC genotype (OR, 2.35 95% CI, 1.11-4.96 P=0.024). The TT genotype was not significantly associated with prostate cancer risk (OR, 0.63 95% CI, 0.16-2.50 P=0.519). Conclusion: It seems that CT genotype is more associated with cancer prostate compare with other genotypes. It appears to be an increased risk of prostate cancer associated with the Arg264Cys substitution in the CYP19 gene.</p> ژن CYP19, سرطان پروستات, PCR-RFLP. CYP19 gene, PCR-RFLP, Prostate cancer 660 668 http://jssu.ssu.ac.ir/browse.php?a_code=A-10-2195-1&slc_lang=fa&sid=1 KH Onsory خدیجه عنصری onsory@gmail.com Yes Islamic Azad University, Parand Branch, Parand, Iran دانشگاه آزاد اسلامی، واحد پرند، پرند، ایران N Vahabi Barzi نسترن وهابی برزی nastaranbarzi@yahoo.com No Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran دانشگاه آزاد اسلامی Z Haji Mehdi Nouri زهرا حاجی مهدی نوری No Islamic Azad University, Ahar Branch, Ahar, Iran دانشگاه آزاد اسلامی، واحد اهر، اهر، ایران M Mousavi منا موسوی No Sistan-Bloochestan University, Zahedan, Iran دانشگاه سیستان و بلوچستان، زاهدان، ایران