Showing 19 results for Amani
L Akrami, M Mirzamani, A Davarmanesh,
Volume 19, Issue 1 (Mar-Apr 2011)
Abstract
Introdution: People with intellectual disability are similar to normal people with regards to their sexual needs. The aim of the present research was to compare sexual problems in mentally retarded and normal adolescents girls aged between 12– 15 years in Tehran.
Methods: This analaytical and cross- sectional research included 90 cases of EMR and 90 cases of normal girls who were chosen by the cluster random sampling method. The statistical tests included Independent t-test, Chi-square,Spearman and Pearson coefficient tests.
Results: The result of the present research indicated that the sexual problems in the EMR Girls was more than normal girls and there was no correlation between the sexual problems and variable demography.
Conclusion: EMR girls with low IQ and adjustment behavior disorder have more problems as compared to normal girls and these can lead to additional problems for themselves and their family.
Molanouri Shamsi, Alinejad, Amani Shalamzari, Aghayari, Asghari Jafarabadi , Talebi Badrabadi,
Volume 19, Issue 5 (Nov-Dec 2011)
Abstract
Introduction: Obesity is a state characterized by a low-grade inflammation that leads to insulin resistance. The aim of the present study was to assess serum interleukin-18 (IL-18), interleukin-6 (IL-6), C-reactive protein (CRP) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) in response to circuit resistance exercise in obese and normal-weight subjects with different levels of physical activity.
Methods: Thirty-two healthy male students participated in the present study. Subjects were divided into 4 groups according to their BMI and level of physical activity: active obese (n=8), active non-obese (n=8), inactive obese (n=8), and inactive non-obese (n=8). To determine serum IL-6, IL-18, CRP, glucose and insulin concentrations, fasting and post-exercise blood samples were obtained. Subjects performed a bout of circuit resistance exercise in 2 sets with 10 repetitions at 60% of 1RM.
Results: Obese subjects comparing non-obese ones showed significant increase in IL-6 and significant decrease in IL-18 concentrations in response to exercise (p<0.05). There was no significant difference between active normal and inactive normal subjects in response to exercise. Also, there were not significant differences in four groups in response to exercise.
Discussion: The significant decrease in IL-18 concentration in the obese group comparing normal group in response to exercise was probably due to anti-inflammatory effects of exercise. Also, recommending this kind of exercise for obese persons with low level of physical activity can improve insulin resistance.
Z Zamani, P Reisi, H Alaei, Aa Pilehvarian,
Volume 20, Issue 2 (May-Jun 2012)
Abstract
Introduction: Studies have proposed that royal jelly(RJ) has various biological activities in different cells and tissues. Since it has been demonstrated that RJ contains compounds having desirable effects on central neurons system and neural functions, the present study aimed to investigate the effect of royal jelly on learning and memory in rats.
Methods: Male wistar rats were divided into two groups, the royal jelly and the control. In the RJ group, the rats received a food that contained 3% RJ instead of regular food for 10 days. Then learning and memory were investigated in these animals through both passive avoidance learning test(1 day and 1 week after receiving electrical shock) and Morris water maze test(1 day and 1 week after a 4-day learning period).
Results: The study results indicated that the food containing RJ in the RJ group significantly increased the time of the first entrance to the dark room one week after the electrical shock in passive avoidance learning test. In other words, the findings suggest an improvement of learning and memory in RJ group. In the acquisition phase of Morris water maze test, rats receiving RJ found the underwater escape plate during less time and distance comparing with the control group. Furthermore, one week after the acquisition phase, in the retention phase, rats spent more time in the quadrant in which the escape plate was previously located.
Conclusion: The present study findings propose that Royal Jelly can improve cognitive processes through positive effects on neural functions and probably has a significant influence on prevention and therapy of some neuronal disorders.
Mh Toode Zaem, H Zandi, Z Tabatabaei, A Haerian-Ardakani, L Ghatre Samani, A Emami,
Volume 21, Issue 3 (Dental Supplement 2013)
Abstract
Introduction: Patients receiving orthodontic treatment get some alterations in their oral cavity environment such as an increase in the levels of microorganism in oral cavity and dental biofilms. Therefore, this study aimed to evaluate as well as to compare the colonization of mutans streptococci in different parts of removable orthodontic appliances.
Methods: In this descriptive analytic study, samples were obtained before and after use of removable appliance plaque and amount of colonization of streptococci mutan was determined in 3 areas including Biteplaque in proximity of first molar teeth, spring, inner surface of removable appliance in proximity of first molar
Results: Results showed that plague index increased significantly after use of removable appliance. (P<0.001) There was a significant difference in amount of colonization of streptococci mutans between spring and biteplaque (p= 0.028)
Conclusion: This study indicated importance of a precise oral hygiene control in patients under treatment with removable orthodontic appliances for prevention of dental caries.
Ma Hosseinpour Feizi, S Shiri Torkamani, E Babaei, M Ghanbarian, V Montazeri, M Halimi,
Volume 21, Issue 5 (NOv-Dec 2013)
Abstract
Introduction: Krupple-like factor4 is a transcription factor which is involved in many cancers including Breast cancer. Breast cancer is the most common malignancy among women. Due to the high prevalence of these tumors, there are ongoing efforts to find molecular markers which can recognize nontumoral from tumoral tissues. Therefore, the aim of this study was to evaluate the potential usefulness of KLF4 as a potential diagnostic and therapeutic molecular marker in breast cancer.
Methods: In the current study, 31 tumoral and 21 non tumoral adjacent tissues were evaluated. Transcription levels were measured by Semiquantitative Reverse Transciptase-Polymerase Chain Reaction and were normalized by the ß2m as an endogenous PCR control. Data was analyzed by spss software, one-way ANOVA and T-test.
Results: The results showed that: 1) KLF4 is over expressed in Breast tumors rather than adjacent normal tissues. 2) KLF4 is an oncogene in breast tumors (at least in IDC type). 3) The KLF4 expression levels are related significantly with nature of malignant breast tumors.
Conclusion: Findings do not confirm KLF4 as a diagnostic marker in classification and identification of tumoral tissues from non-tumoral ones in breast, but we can use this marker to identify at least 50% of invasive Ductal Carcinoma in breast and utilize it as a potential predictive factor to demonstrate severity degree in various tumors.
A Fathi, F Amani, E Khoshbaf,
Volume 22, Issue 5 (Nov-Dec 2014)
Abstract
Introduction: The β-thalassemia is one of the most common genetically transmitted blood disorders in the world. Sometimes Homozygote people demonstrate milder form of this disorder called intermedia. In this study, the effect of Hydroxy Urea (HU) was investigated in Thalassemia intermedia patients who were treated monthly by packed cell transfusion as patients with major thalassemia in Bu-Ali Hospital of Ardebil.
Methods: This semi-experimental study consisted of 63 intermediate Thalassemia patients. All patients entered to study after completing inform consent and all transfusions were ceased and patients were treated by HU for 3and 6 months. All patients underwent CBC, Serum ferritin, liver and kidney function tests before starting HU and after 6 months of treatment. Moreover, at the end of 6 months, the patients’ transfusion need was evaluated. The test results were analyzed utilizing descriptive statistical methods (such as tables, graphs) and non-parametric Wilcoxon test via SPSS software (Version 18).
Results: After 6 months, 60 patients (95.2%) were completely needless of transfusion. In 3 patients (4.8%) transfusion interval prolonged more than one month. The study findings demonstrated a decrease in mean of ferritin level, and an increase in mean of hemoglobin level. Furthermore regarding the complications, AST, ALT, and BUN significantly increased after treatment with HU.
Conclusion: In thalassemia intermedia patients, HU can obviate the need for regular transfusion and increase the mean of Hb level.
Sh Hajighahramani ,
Volume 24, Issue 4 (Jul 2016)
Abstract
Introduction: Propofol is an injectable anesthetics, which is used as sedation in surgery operations. The aim of the present study was to investigate the analgesic activity of chlorpheniramine, and its comparison with morphine and fentanyl ( opiod agents) in intraperitoneal propofol anesthesia in mice.
Methods: 40 adult male mice were randomly assigned in 4 groups. Anesthesia was induced by intraperitoneal administration of different combinations including: group1 (Normal saline and propofol), group 2 ( chlorpheniramine and propofol), group 3 ( morphine and propofol) and finally group 4 (fentanyl and propofol).
Results: Time of surgical anesthesia in group 1 ( 12.7± 3.5) was shorter than group 2 (23.3 ±4.4) , group3 (25.2 ± 6.5), and group 4 (27.4± 3.7) (P < 0.05). Toe pinch score was significantly different in the first group (2.7± 0.5) and the second group (1.8 ± 0.7) (P < 0.05). Inhibition percentage in the second group (53.97) was more than first group (37.3) and it was ,also, less than third group (88.73) and fourth group (84.06) respectively. Significant decrease was observed in respiratory the rate from baseline values ( 148.9 ± 6.3) at all time points of anesthesia in all groups.
Conclusion: Based on the present results it is concluded that opioid agents (morphine and fentanyl) were induced good analgesic and anesthetic statues in combination with propofol in mice. Compared to morphine and fentanyl, chlorpheniramine analgesia is poor. Thus, chlorpheniramine ( H1 antagonist) could be used in mice as analgesic and premedication agent in minor operations that there is no need to potent analgesics.
Najmeh Najafi, Habibollah Hosseini, Maryam Hatami, Mahmmod Vakili, Farzaneh Shishebor, Mohammad Zamanian, Elham Hakimizadeh,
Volume 26, Issue 3 (Jun 2018)
Abstract
Introduction: Post-operative pain reduction is one of the problems in the patients with preoperative narcotic dependency. Morphine is the most common drugs to control postoperative pain. Due to resistance to morphine and its side effects in addict patients, using of adjuvant drugs such as ketamine has increased. The aim of this study was to evaluate the effect of adding ketamine to morphine in patients addicted to opioid with post orthopedic operation pain.
Methods: In a double blind clinical trial, 60 patients undergoing orthopedic operation with history of opioid consumption were randomly divided in 2 groups. Post operation, the first group received morphine 20 mg and the second group received morphine 20 mg + ketamine 100 mg via IV patient-controlled analgesia (IPCA). The pain score as visual analogue scale (VAS), sedation score, and nausea and vomiting were evaluated at 1, 6, 12 and 24 hours post operation. SPSS v.20 was used for data analysis.
Results: Results showed that dose of morphine consumption in morphine group was significantly increased compared to the morphine + ketamine group (p ˂ 0.001). In addition, only at 12 hours after surgery the mean of pain score in the morphine group was significantly reduced compared to the second group (p = 0.02). The mean of sedation score at 1 (p ˂ 0.001), 6 (p = 0.002), 12 (p = 0.001) and 24 (p ˂ 0.001) hours after surgery in the morphine group was increased compared to the other group. At 1 hour, the mean of nausea and vomiting scores in the morphine group was significantly reduced compared to the morphine + ketamine group (p = 0.024).
Conclusion: Addition of ketamine to morphine in the patients with history of opioid consumption reduced using of the morphine. But had no effect on pain and sedation score reduction.
Jaleh Khanifar, Ali Hatef Salmanian, Reza Haji Hajisseini, Jafar Amani, Rohoallah Kazemi,
Volume 26, Issue 10 (Jan 2019)
Abstract
Introdution: E. coli O157:H7 with its ability of quick implantation inside gastrointestinal tract that causes hemolytic uremic and bloody diarrhea in humans is an important subject to investigate. One of the effective ways to prevent these infections is using nanovaccines prepared from immunogenic recombinant protein from bacterial virulence factors. In this research, the chitosan encapsulated by recombinant protein of EIT with and without Stx2B were introduced to BALB/c mice and immunogenicity was evaluated and compared.
Methods: In this experimental study the recombinant protein of EIT and Stx2B were nanoparticulated with chitosan through ionic gelation method after expression and purification with Ni-NTA column and approval by Western blotting. After Vaccinations antibodies against rStx2B and rEIT in the mice’s serum and feces were detected by ELISA. Challenge test for neutralization and protection against Stx2 toxin was applied with immunized serum by Fisher's exact test.
Results: Evaluation of IgA and IgG antibody levels in the mice’s serum and also the IgA level in their feces showed more appropriate immunity oral-injection groups with the both nanoparticulated antigens. The protection challenge study show that, the mice group which received rEIT+ rStx2B could neutralize the toxin activity significant difference (P<0.05) between test and control groups of mice was recorded.
Conclusion: The data indicate these multiple vaccine candidates with both nanoparticulated recombinant proteins EIT and Stx2B with chitosan, provide more effective protection against of E. coli O157:H7
Farideh Malekzadeh, Behnaz Navid, Maryam Mohammadi, Reza Omani-Samani,
Volume 28, Issue 7 (10-2020)
Abstract
Introduction: Infertility could decrease the self-esteem of the infertile couples. Using the defensive style is one way to deal with stressful events. Therefore, the aim of this study was to investigate the role of self-esteem and defense mechanisms based on the cause of infertility.
Methods: In this cross-sectional study, 400 infertile couples referred to infertility center in Tehran, Iran. Participates classified in 4 groups for the cause of infertility: female, male, both and unknown. Data gathering tools in this study were demographic questionnaire, Rosenberg Self-Esteem Scale and Defense Styles Questionnaire (DSQ). Data were analyzed (SPSS 18 software) using paired t-test for comparison between the groups according to the cause of infertility and using regression analyses tests.
Results: The results of this study showed that men in female infertility group has significantly higher self –esteem than other groups (P<0.049). In couples, husbands with female and male factor showed more self-esteem than their wives (P< 0.001, P<0.008, respectively). In defense mechanisms, there was no difference between women, men, and couples. In this study, self-esteem showed a negative relationship with immature and neurotic defense mechanisms and a positive relationship with mature defense mechanism.
Conclusion: The findings of this study showed that women had higher levels of vulnerability than their husbands did even when they were not the cause of infertility so they have a low self-esteem. Therefore, it is suggested that infertile women receive more psychological counseling than men, and in order to facilitate the treatment of infertile couples and provide better services to improve marital relationships and solve their problems, differences between men and women about psychological issues should be considered.
Mohammad Hasan Kordi Ashkezari, Mansur Sahebozamani, Abdolhamid Daneshjoo, Hamid Abbasi Bafghi,
Volume 28, Issue 7 (10-2020)
Abstract
Introduction: Ankle sprains are one of the most common sports injuries. This injury can affect the kinematics of the athlete's lower extremities. Therefore, the aim of this study was to compare the effect of 6 weeks of balancing and hopping strengthening training on the kinematics of the lower extremities of athletes with functional ankle instability while running.
Methods: The present study was a randomized clinical trial on 36 athletes with functional ankle instability who were randomly divided into three groups: hopping training, balance strengthening and control. The training lasted for six weeks and 3 sessions per week. Kinematic data were recorded by 3D OptiTrack camera while running at 10 km/h before and after training. SPSS software version 20 and ANCOVA test were used to compare the effect of exercises.
Results: The results showed that there was a significant difference among the 3 groups in dorsiflexion (P = 0.009), inversion (P = 0.001) and knee flexion (P = 0.001). The results of Benferoni test also showed that hopping training in dorsiflexion, ankle inversion and knee flexion were significantly different from the control group (P = 0.009, P = 0.001, P = 0.001). The results also showed that balance strengthening training in the above movements were significantly different from the control group (P = 0.005, P = 0.002, P = 0.006) and in knee flexion, hoping training showed a significant difference compared to balance strengthening training (P =0.012). The results showed that both hopping and balance strengthening training improved the dorsiflexion, inversion and knee flexion angles in the initial contact in running. However, hopping exercises is better than balance strengthening in improving knee flexion angles.
Conclusion: Therefore, according to the presented results, it can be concluded that the rehabilitation course of ankle sprains in athletes, coaches and sports rescue specialists should use a combination of balance strengthening training and hopping as a comprehensive program. In addition, hopping training can be used as a good alternative to balance training in places where there is not enough equipment.
Ameneh Marzban, Vahid Rahmanian, Azam Namdar, Marzieh Zamani,
Volume 28, Issue 11 (1-2021)
Abstract
Introduction: Health information seeking and knowledge acquisition play an important role in the management of chronic diseases such as hypertension. The purpose of this study was to determine the information sources used by hypertensive patients in self-management of patients referred to Jahrom... health centers.
Methods: This cross-sectional study was performed on 396 hypertensive patients who were selected by cluster sampling from six urban-rural health centers of Jahrom City in 2016. Data gathering tool was a 17-question researcher-made questionnaire that was used after validation and reliability. Data were analyzed using descriptive statistics and chi-square test by SPSS version 16 software.
Results: 61.40% (243 patients) of patients with hypertension had information about their disease after developing hypertention. Most of their information sources were physicians and health workers 60.02% (236 people), family and friends 31.12% (122 people) and other patients 25.8% (101 people) and mass media 24.51% respectively. 96 people). 35.4% (n = 86) of patients admitted that this acquisition of knowledge has decreased their referrals to specialized levels The most important reasons for not obtaining information in 35.29% (140 people) were difficulty and lack of access to information resources.
Conclusion: The results of this study showed a relatively high and good knowledge of the patients after the disease. The most frequently used sources of information were physicians and health workers. Therefore, it is imperative that health professionals use effective ways of transmitting information to these people..
Elahe Darvishi , Asra Amani, Somayeh Mirsadeghi, Behrang Shiri Varnamkhasti ,
Volume 30, Issue 3 (6-2022)
Abstract
Introduction: Photothermal therapy is a method of cancer treatment that plasmonic nanoparticles are used to convert infrared light into local heat. Due to the plasmonic properties of gold nanoparticles, this compound was used as a contrast agent. The aim of this study was to synthesize gold nanoparticles with different conjugations for photothermal therapy.
Methods: This research was an experimental study. The method used for the synthesis of spherical and rod gold nanoparticles in this research was the Seeding Method. The nanoparticles were then conjugated with various compounds such as rifampicin, quercetin and RGD. Then, the physical and chemical properties of nanoparticles were determined by DLS, UV-Vis and TEM methods. Cytotoxicity test was also performed on MCF-7 ((Michigan Cancer Foundation-7)) cell line. Cell viability was calculated using prism software. Differences were compared by analysis of variance (ANOVA) using SPSS version 16 software.
Results: In the UV test, two-peaked rod nanoparticles were observed in the range of 523 and 738 nm, and in the case of spherical nanoparticles at 535 wavelengths, which indicates the correct synthesis without impurities and with the appropriate size .In the cell test, a decrease in cell viability was observed compared to the control group. In the first 24 hours, spherical nanoparticles had the highest lethality to the point that at a concentration of 20 μg / ml, it had almost 50% lethality. In addition, after 48 hours at low concentrations, rod nanoparticles showed better results, so they were more suitable. By targeting these nanoparticles to specific cancer cells, in addition to being used to kill cancer cells, the effect of these nanoparticles on healthy cells can be prevented. By conjugating different compounds on the surface of these nanoparticles, cell uptake can also be increased and cancer cells can be killed using photothermal therapy.
Conclusion: According to the results obtained in this study, it seems that low-concentration of gold nano-rods are more suitable for photothermal therapy.
Ashraf Moini , Farideh Malekzadeh, Behnaz Navid, Maryam Mohammadi, Reza Omani-Samani,
Volume 31, Issue 8 (11-2023)
Abstract
Introduction: Shift work disorder (SWD) is a sleep disorder that affects the circadian rhythm and is characterized by symptoms such as excessive daytime sleepiness and insomnia. This condition can significantly increase the risk of accidents and diminish the overall quality of life for individuals affected by it. Therefore, using the four-question of shift work disorder questionnaire (SWDQ) can be useful for identifying people at risk of SWD. In this research, we evaluated the accuracy and consistency of the Persian adaptation of the SWDQ among female employees.
Methods: In this descriptive cross-sectional investigation, a sampling available method was employed to select employed women who were referred to Royan Institute, Arash Hospital, and Gynecological Office in Tehran. It was used translated and reverse translation methods for the questionnaire of SWDQ. Statistical analysis was performed by using the Statistical Package for the Social Sciences (SPSS version 16, Inc. Chicago, IL, USA).The tests used in this study were Cronbach's alpha, internal correlation, and confirmatory factor analysis.
Results: In terms of content validity rate (CVR) with an average of 70% (questions 80%, 80%, 60% and 60%, respectively) and content validity index (CVI) with an average of 87.5% (questions 100%, 90%, 80% and 80%, respectively) was acceptable. The internal homogeneity of the SWD questionnaire with Cronbach's alpha was 63.4% and deleting each of the four items of the questionnaire reduced it. Moreover, the range of total correlated changes for the questionnaire was from 0.339 to 0.488, which was more than the minimum of 0.3.
Conclusion: Overall, the validity and reliability of the Persian version of SWDQ (the four-item) have acceptable.
Corresponding Author:Farideh Malekzadeh
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Peyman Kaikhosro Doulatyari, Sedigheh Hosseinpour Delavar, Mehran Ghahramani, Mohammad Rouzbahani,
Volume 31, Issue 12 (3-2024)
Abstract
Introduction: Exercise training by modulating blood pressure and heart rate have a protective role for middle-aged cardiac patients. Aim of this study was to compare the effect of eight weeks of aerobic and combined exercise on some hemodynamic indicators in middle-aged male patients undergoing coronary artery bypass graft surgery.
Methods: In this clinical trial, a sample of 30 middle-aged men who underwent coronary artery surgery in 2023 were enrolled after meeting predetermined eligibility criteria and randomized for participation. They were divided into three aerobic (n=10), combined (n=10) and control (n=10) groups. The individuals of the 2 intervention groups performed selected aerobic and combined exercises (with an intensity of 55 - 75% of the maximum heart rate, for 60 minutes) for 8 weeks, 3 sessions per week. Blood pressure, heart rate and peripheral oxygen saturation (SpO2) were measured before and after the intervention. The parametric paired sample t-test, one-way ANOVA test and Tukey's Test were used to examine differences at a significance level of P ≤ 0.05.
Results: The effect of aerobic exercises on systolic blood pressure (P=0.036), diastolic blood pressure (P=0.040) and heart rate (P=0.013) was significant and caused a decrease in these indicators, but the decrease in the combined group was not significant (P>0.05). The intergroup effect difference was not significant (P>0.05). In both aerobic (P=0.000) and combined (P=0.007) groups, the peripheral oxygen saturation has increased significantly and intergroup mean difference was significant (P=0.004).
Conclusion: It seems that aerobic and combined exercises as a helpful intervention strategy to improve hemodynamic indicators, make the patient more adaptable to the conditions after coronary artery bypass graft surgery.
Mansoureh Hamzehrad, Mandana Niknam, Fatemeh Amani Kelarijani,
Volume 32, Issue 4 (7-2024)
Abstract
Introduction: Mastectomy surgical method greatly affects the long-term quality of life of women with breast cancer. Mastectomy can play an important role in sexual desire and marital intimacy. The purpose of this study was to investigate the mediating role of body image concern in the relationship between sexual function and marital intimacy in women with mastectomy breast cancer.
Methods: The research method was a descriptive correlation type. The population included all the patients with mastectomy breast cancer whose list was available in 2022 in hospitals and charity centers related to cancer in Tehran. 145 women who underwent mastectomy were selected by available sampling method. Research tools included Thompson and Walker's marital intimacy questionnaires, Rosen et al.'s Female Sexual function Index, and Littleton's Body Image Concern Inventory (1,2,3). Relationships between variables were done with Pearson correlation test and structural equation modeling test using SPSS version 16 and Amos version 24 software.
Results: The findings showed that Body Image Concern does not play a mediating role in the relationship between sexual function and marital intimacy of mastectomized women (P<0.05). Pearson's correlation test also showed that there is a positive and significant relationship between sexual function and marital intimacy (P<0.05) and there is a significant negative relationship between Body Image Concern and marital intimacy (P<0.05) and between sexual function and Body Image Concern no significant relationship was observed (P<0.05).
Conclusion: Psychologists can use the findings of this study to teach the nature of these women's sexual problems and seek to identify factors that help better intimacy in these women's marital relationships.
Danial Naghipour, Aref Arminfar, Zahra Sahraneshin Samani, Lida Sepanloo, Hessamedin Babaei, Mohammad Hossein Hasani, Behrooz Yahyaei,
Volume 32, Issue 10 (1-2025)
Abstract
Introduction: Given the widespread issue of methamphetamine addiction and its damaging effects, coupled with the crucial role of the kidneys in maintaining bodily equilibrium, we chose to undertake this study.
Methods: Forty rats were randomly divided into five equal groups: control, methamphetamine, methamphetamine with exercise, methamphetamine with berberine hydrochloride, and methamphetamine with both exercise and berberine hydrochloride. The administration of methamphetamine at a dose of 15 mg/kg intraperitoneally for a duration of 4 days every 12 hours and berberine hydrochloride 100 mg/kg intraperitoneally for a duration of 4 weeks daily has been conducted. Aerobic exercise was performed in the form of running on a rodent treadmill for 8 weeks with moderate intensity. Twenty-four hours following the final exercise and administration of berberine hydrochloride, kidney tissue was extracted and examined under a light microscope, in accordance with the ethics committee's guidelines.
Results: In the methamphetamine group, the glomerulus diameter decreased, hyperemia and tissue disorganization occurred, and the cells of the proximal and distal convoluted tubules were atrophied. In the methamphetamine group, with exercise, there was a decrease in diameter in some glomeruli and changes in hyperemia and an increase in the diameter of blood vessels. In the group treated with methamphetamine and berberine hydrochloride, there was a noted shrinkage of glomeruli and an increase in urinary space. In the group receiving methamphetamine, exercise, and berberine hydrochloride, the quantity and size of glomeruli as well as the spaces between them, were normal and without irregularities.
Conclusion: This research demonstrated that both aerobic exercise and berberine hydrochloride can mitigate the damaging histopathological impacts of methamphetamine on the kidney, indicating that their simultaneous use may offer enhanced protective benefits. effect
Narges Laghaei, Sedigheh Hosseinpourdelavar, Mehran Ghahramani,
Volume 33, Issue 1 (4-2025)
Abstract
Introduction: Doxorubicin increases oxidative stress and cardiac damage. ERK1/2, PI3k, and IL-18 seem to play an important role in increasing cardiac damage. The aim of the present study was to investigate the effect of eight weeks of interval training with curcumin on ERK1/2, PI3k, and IL-18 in the heart tissue of cancer mice treated with doxorubicin.
Methods: In this experimental study, Fourteen days post-cancer induction, a total of 40 rats aged between 4 to 6 months were divided into 5 distinct groups: cancer control+doxorubicin, cancer control+no drug, cancer+intermittent exercise+doxorubicin, cancer+curcumin+doxorubicin, and cancer+intermittent exercise+curcumin+doxorubicin. Curcumin was administered to two of these groups at a dosage of 100 mg/kg, one hour after training sessions. The high-intensity interval training (HIIT) protocol consisted of six intervals each lasting 3 minutes and 20 seconds at 80%-95% of VO2max, interspersed with 2 minutes of active recovery at 30%-35% of VO2max. Enzyme-Linked Immunosorbent Assay (ELISA) was utilized to examine variables, and the statistical analyses were conducted using SPSS software version 16, applying ANOVA along with Bonferroni post hoc tests.
Results: ERK1/2 was significantly increased in the cancer control + doxorubicin group compared to the cancer control + no drug group (P=0.001). In the interval training + curcumin + doxorubicin group, ERK1/2 was significantly decreased compared to the cancer control + doxorubicin group (P=0.001). PI3K was significantly decreased in the cancer control + doxorubicin group compared to the cancer control + no drug group (P=0.001). PI3K was significantly increased in the interval training + curcumin + doxorubicin group compared to the cancer control + doxorubicin group (P=0.001). IL-18 was significantly increased in the cancer control + doxorubicin group compared to the cancer control + no drug group (P=0.001). In the interval training + curcumin + doxorubicin group, IL-18 was significantly decreased compared to the cancer control + doxorubicin group (P=0.001).
Conclusion: The administration of doxorubicin resulted in elevated levels of ERK1/2 and IL-18 while reducing PI3K in the heart tissue of cancer-affected mice. In contrast, the combination of curcumin administration and exercise reduced ERK1/2 and IL-18 levels while increasing PI3K. While both curcumin and exercise individually showed considerable benefits in enhancing these factors, their combined effect produced even more effective outcomes.
Somayeh Bakhtiari Dehbalaei, Nasrin Poroun, Mehran Ghahramani, Abdolhamid Zokaei, Mohammad Ghahramani,
Volume 33, Issue 5 (8-2025)
Abstract
Introduction: Parkinson’s disease (PD) is a prevalent neurodegenerative disorders characterized by pathological changes in an area of the brain known as the substantia nigra pars compacta (SNpc), which contains a high density of dopaminergic neurons. A key factor that probably contributes to the development of Parkinson’s disease is the accumulation of alpha-synuclein, followed by the activation of microglia and astrocytes, leading to chronic neuroinflammation. The aim of the recent review study was to investigate the effects of aerobic exercise on modulating inflammation in Parkinson’s disease.
Methods: This systematic review analyzed research on the effects of various exercise routines on inflammatory markers in both human and animal models of Parkinson’s disease. Scientific articles were accessed using databases such as Pubmed, Springer, Hindawi, Scopus, Google Scholar, SID, and Mag Iran, with keywords, including Parkinson’s disease, aerobic exercise, neuroinflammation, and inflammatory cytokines. Out of 962 studies analyzed in the last 15 years, 15 studies met the inclusion criteria.
Results: The results indicated that aerobic exercise, encompassing both continuous and interval workouts effectively lowered inflammatory markers in Parkinson’s disease, particularly in animal models. Nonetheless, there have been few studies comparing different forms of aerobic exercise, like continuous and interval training, highlighting a need for further research in this field.
Conclusion: Aerobic exercise might be a beneficial method to manage inflammation in Parkinson’s disease and can serve as a non-pharmacological approach to enhance the issues associated with this condition.
