Volume 30, Issue 5 (8-2022)                   JSSU 2022, 30(5): 4828-4841 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Saberi R, Ahmadi A, Khodabandeh Z, Alaee S. Effect of Taurine and Curcumin on In-Vitro Fertilization in NMRI Mice Treated with Acrylamide. JSSU. 2022; 30 (5) :4828-4841
URL: http://jssu.ssu.ac.ir/article-1-5606-en.html
Abstract:   (89 Views)
Introduction: The aim of this study was to evaluate the effect of taurine and curcumin on in vitro fertilization (IVF) in female mice treated with acrylamideand and its effect on malondialdehyde (MDA) concentration and total antioxidant capacity (TAC).
Methods: A total of 48 adult female NMRI mice were randomly divided into 6 groups, including control, curcumin 200 mg / kg, taurine 150 mg / kg, acrylamide 5 mg / kg, acrylamide 5 mg / kg + curcumin 100 and 200, acrylamide 5 mg / kg + Taurine 75 and 150 mg / kg.  The drugs were administered orally for 35 days, and then IVF rate, MDA and TAC concentrations were examined in each group.  
Results: The results showed a significant decrease in oocyte, fertilization percentage, 2, 4 and 8 cell, Compact and blastocytes embryos in the acrylamide group compared to the control (P<0.05). In acrylamide group, MDA concentration increased and TAC showed a significant decrease compared to other groups (P<0.05). There was a significant increase in oocyte count and fertilization percentage in taurine group compared to the control (P‌<0.001). A significant increase in the above parameters was observed in the acrylamide + taurine group at a dose of 150 mg / kg compared to the acrylamide group (P<0.05). Percentage of fertilization and embryos of 2, 4 and 8 cells, Compact and blastocytes in the curcumin group showed a significant decrease compared to the control (P<0.05).
Conclusion: The results indicate that taurine has a better performance in reducing the side effects of acrylamide than curcumin. Since curcumin can prevent IVF, it should be used with more caution at the beginning of pregnancy.
 
Full-Text [PDF 977 kb]   (57 Downloads)    
Type of Study: Original article | Subject: other
Received: 2021/11/14 | Accepted: 2022/02/21 | Published: 2022/08/6

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | SSU_Journals

Designed & Developed by : Yektaweb