Volume 27, Issue 12 (2-2020)
JSSU 2020, 27(12): 2215-2228 |
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Karimi S, Raoufi S, Bagher Z. Investigation of Stem Cell Aging Throughout the Lifetime and Therapeutic Opportunities. JSSU 2020; 27 (12) :2215-2228
URL: http://jssu.ssu.ac.ir/article-1-4980-en.html
URL: http://jssu.ssu.ac.ir/article-1-4980-en.html
Abstract: (4638 Views)
Introduction: Aging is a natural phenomenon that is caused by changes in the cells of the body. Theoretically, aging starts from birth and lasts throughout life. These changes affect the function of the cells. Also, in old tissues, the capacity for homeostasis and tissue repair is decline due to destructive changes in specific tissue stem cells, niche of stem cells and systemic factors that regulate stem cell activity. Understanding molecular pathways that disrupt stem cell function during aging is crucial for the development of new treatments for aging-associated diseases. In this article, the symptoms of stem cell aging and the key molecular pathways that are commonly used for the aging of stem cells were discussed. We will consider experimental evidence for all of the mechanisms and evaluate the way that can slow down or even stop the aging process. Finally, we will look at the aging process of three types of stem cells.
Type of Study: Review article |
Subject:
General
Received: 2019/10/3 | Accepted: 2020/05/18 | Published: 2020/05/18
Received: 2019/10/3 | Accepted: 2020/05/18 | Published: 2020/05/18
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