Volume 27, Issue 10 (1-2020)                   JSSU 2020, 27(10): 1981-1992 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mirza Aghasi A, Ghorbian S. Analysis of SEPT9 Gene Promoter Methylation Status in Esophageal Squamous Cell Carcinoma. JSSU. 2020; 27 (10) :1981-1992
URL: http://jssu.ssu.ac.ir/article-1-4805-en.html
Abstract:   (1094 Views)
Introduction: The changes in the level of SEPT9 gene promoter methylation can contribute to the formation of esophageal squamous cell carcinoma. The aim of this study was to evaluate the level of changes in the level of SEPT9 gene promoter methylation in the esophageal squamous cell carcinoma.
Methods: In the present case-control study, we collected 75 paraffin blocks of esophageal cancer tissues and 75 paraffin blocks healthy tissues, which were referred to the Noor-E-Nejat and Tabriz International Hospitals during 2013-2017. After DNA extraction and treatment with sodium metabisulfite, the changes of SEPT9 gene promoter methylation assessed using high resolution melting (HRM) technique. The data were analyzed by SPSS 22 and Chi-square test.
Results: Our findings did not show a statistically significant difference between the changes of SEPT9 gene promoter methylation in cancer tissues compared to the healthy tissues (P=0.106).
Conclusion: This study shows that SEPT9 gene promoter methylation cannot contribute to the esophageal squamous cell carcinoma cancerogenesis
Full-Text [PDF 737 kb]   (463 Downloads)    
Type of Study: Original article | Subject: Genetics
Received: 2019/01/29 | Accepted: 2019/04/13 | Published: 2020/02/22

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2021 CC BY-NC 4.0 | SSU_Journals

Designed & Developed by : Yektaweb