Introdution: Epilepsy is known as a cerebrovascular disorder with a continuing readiness for epileptic seizures and psychological neuropsychological outcomes. The purpose of this study was to investigate the effectiveness of acceptance and commitment therapy on psychological well-being, quality of life and depression in patients with epilepsy.
Methods: The study was a quasi- experimental with a pre-test, post-test design with a control group. The statistical population of the study consisted of 76 patients, of whom 20 were selected by available sampling method and they were randomly divided into two experimental and control groups. The experimental group received the acceptance and commitment group therapy in eight sessions each of which in two hours. Before and after the intervention, the Multidimensional Reef psychological well-being questionnaire, Quality of life questionnaire, Beck Depression Inventory was administrated in both groups.  Data were analyzed using covariance test and SPSS20 software.
Results: The findings of this study showed that acceptance and commitment based treatment had a significant effect on psychological well-being, quality of life and depression in the level of error less than p <0.0001. And the result of P-value was reported as 42.602, 17. 927, 53.528, respectively.
Conclusion: The results of this study show that acceptance and commitment therapy is significantly effective in the patients with epilepsy using techniques such as attention to the present time, acceptance and cognitive impairment in increasing psychological well-being and quality of life and reducing depression. Considering the effect of admission therapy and commitment in using this method at all levels of prevention and treatment of the patients with physical and mental illness seems necessary.