Evaluation of oral health and bleeding management after dental procedures of patients with congenital bleeding disorders in Tehran city in 2015: A comparative study

Ahmadi-Motamayel, F; Hadian, N

Volume 24, Issue 6 (sep 2016) JSSU 2016, 24(6): 460-467 | Back to browse issues page

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Ahmadi-Motamayel F, Hadian N. Evaluation of oral health and bleeding management after dental procedures of patients with congenital bleeding disorders in Tehran city in 2015: A comparative study. JSSU 2016; 24 (6) :460-467
URL: http://jssu.ssu.ac.ir/article-1-3588-en.html

Evaluation of oral health and bleeding management after dental procedures of patients with congenital bleeding disorders in Tehran city in 2015: A comparative study

F Ahmadi-Motamayel ^*

, N Hadian

Abstract: (5498 Views)

Introduction: Platelets and clotting factors dysfunction lead to hereditary hemorrhagic disease. In according to the importance of these diseases, the aim of this study was the evaluation of oral health and bleeding management of the patients with congenital bleeding disorders in Tehran city in 2015.

Methods: In this case-control study, 68 hemophilic patients as case group were compared with 50 healthy people as control group. These samples matched in according to age and gender. DMFT/S and GI index (caries index and gingival index) was recorded and bleeding management evaluated by the patient's medical records and interviews. Data analyzed using SPSS version 16 and the level of significant was considered p ≤0.05.

Results: Patients group The mean of age in hemophilic patients was 12.54 ± 2.94 and in the control group was 12.50±3.1. DMFT, DMFS and GI index was higher in the health group. With increasing the age of the patients gingival inflammation index also increased significantly (p=0.001) so that 70% of individual with age higher than 15 had grade 3 gingival inflammation.

Conclusions: Patients and parents awareness about dental hygiene and regular dental visit is very important for caries prevention and reduction of DMFT/S and GI index and regular dental visits are essential for the patients.

Keywords: Oral Health, Bleeding Disorders, Congenital Bleeding Disorders

Full-Text [PDF 1181 kb] (2025 Downloads)

Type of Study: Original article | Subject: Dental
Received: 2016/01/25 | Accepted: 2016/05/14 | Published: 2016/10/5

References

1. 1- Bos MH, Camire RM. Blood coagulation factors V and VIII: Molecular Mechanisms of Procofactor Activation. J Coagul Disord 2010; 2(2): 19-27.

2. 2- Lippi G, Pasalic L, Favaloro EJ. Detection of mild inherited disorders of blood coagulation: current options and personal recommendations. Expert Rev Hematol 2015; 8(4): 527-42.

3. 3- Puy C, Tucker EI, Wong ZC, Gailani D, Smith SA, Choi SH, et al. Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates. J Thromb Haemost 2013; 11(7): 1341-52.

4. 4- Smith SA, Travers RJ, Morrissey JH. How it all starts: Initiation of the clotting cascade. Crit Rev Biochem Mol Biol 2015; 50(4): 326-36.

5. 5- Naderi M, Dorgalaleh A, Alizadeh S, Tabibian S, Hosseini S, Shamsizadeh M, et al. Clinical manifestations and management of life-threatening bleeding in the largest group of patients with severe factor XIII deficiency. Inter J hemato 2014; 100(5): 443-49.

6. 6- White GC, Rosendaal F, Aledort LM, Luscher J, Rothschild C, Ingerslev J. Definitions in hemophilia. Thrombosis and haemostasis-stuttgart 2001; 85(3): 560.

7. 7- Manco-Johnson MJ, Abshire TC, Shapiro AD, Riske B, Hacker MR, Kilcoyne R, et al. Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia. New England J Med 2007; 357(6): 535-44.

8. 8- Ivanciu L, Toso R, Margaritis P, Pavani G, Kim H, Schlachterman A, et al. A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia. Nat Biotechnol 2011; 29(11): 1028-33.

9. 9- Rogers GL, Herzog RW. Gene therapy for hemophilia. Front Biosci (Landmark Ed) 2015; 20: 556-603.

10. 10- Goodeve AC, Peake IR. The molecular basis of hemophilia A: genotype-phenotype relationships and inhibitor development. Semin Thromb Hemost 2003; 29(1): 23-30.

11. 11- Zaliuniene R, Peciuliene V, Brukiene V, Aleksejuniene J. Hemophilia and oral health. Stomatologija 2014; 16(4): 127-31.

12. 12- Žaliūnienė R, Aleksejūnienė J, BrukienėV, Pečiulienė V. Do hemophiliacs have a higher risk for dental caries than the general population? Med 2015; 51(1): 46-56.

13. 13- Ziebolz D, Stühmer C, Hornecker E, Zapf A, Mausberg R, Chenot J. Oral health in adult patients with congenital coagulation disorders–a case control study. Haemophilia 2011; 17(3): 527-31.

14. 14- Singh J, Singh N, Kumar A, Kedia NB, Agarwal A. Dental and periodontal health status of Beta thalassemia major and sickle cell anemic patients: a comparative study. J Int Oral Health 2013; 5(5): 53-8.

15. 15- Makarem A, Talebi M, Mazhari F, Kiyanosh N. Evaluation of Oral and Dental Health Status of Khorasan Province Hemophilic Patients in 2004. J Mashhad Dent School 2008; 32(2): 161-8.

16. 16- Martínez-Beneyto Y, Vera-Delgado MV, Pérez L, Maurandi A. Self-reported oral health and hygiene habits, dental decay, and periodontal condition among pregnant European women. Int J Gynaecol Obstet 2011; 114(1): 18-22.

17. 17- E coli. U.S. Food and Drug Administration. Accessed Feb 23, 2015. available from: www.foodsafety.gov.

18. 18- Zaliuniene R, Peciuliene V, Brukiene V, Aleksejuniene J. Hemophilia and oral health. Stomatologija 2014; 16(4): 127-31.

19. 19- Mielnik‐Błaszczak M. Evaluation of dentition status and oral hygiene in Polish children and adolescents with congenital haemorrhagic diatheses. Int J Paediatr Dent 1999; 9(2): 99-103.

20. 20- Sonbol H, Pelargidou M, Lucas V, Gelbier M, Mason C, Roberts G. Dental health indices and caries‐related microflora in children with severe haemophilia. Haemophilia 2001; 7(5): 468-74.

21. 21- Brewer A, Correa ME. Guidelines for dental treatment of patients with inherited bleeding disorders. Haemophilia 2005; 11: 504-09.