Investigation the Effect of Carbamazepine on Acquisition Passive  Avoidance Learning in Male Rat Model of Seizure

Gholampoor Fard, F; Heydarieh, N; Moghaddami Rad, mohamad

Volume 24, Issue 5 (Aug 2016) JSSU 2016, 24(5): 398-408 | Back to browse issues page

Mendeley

Zotero

RefWorks

Gholampoor Fard F, Heydarieh N, Moghaddami Rad M. Investigation the Effect of Carbamazepine on Acquisition Passive Avoidance Learning in Male Rat Model of Seizure. JSSU 2016; 24 (5) :398-408
URL: http://jssu.ssu.ac.ir/article-1-3566-en.html

Investigation the Effect of Carbamazepine on Acquisition Passive Avoidance Learning in Male Rat Model of Seizure

F Gholampoor Fard

, N Heydarieh ^*

, Mohamad Moghaddami Rad

Abstract: (6982 Views)

Introduction: Epilepsy is the most common disorder of the central nerves system. Patients suffering from epilepsy can experience a wide range of neuropsychological disorders such as impaired memory, disturbances in attention and information processing. Due to the effect of anticonvulsant carbamazepine and its effect on the memory and learning, the aim of this study was investigating the effect of Carbamazepine on passive avoidance learning in male rats seizure model.

Methods: 30 male Wistar rats with an average weight of 230±20 g were used in the study. Animals were randomly divided into 5 groups. Seizure was induced by administration of pentylenetetrazole (PTZ: 60 mg/kg, ip). After induction of seizure the learning and memory of rats was tested in shuttle box. Latency to enter the dark room memory was evaluated as indicators of learning and memory. The data were analyzed by one way variance analysis and Tukey’s test using SPSS.

Results: Pentylenetetrazole-induced seizures (PTZ) in acquisition group significantly reduced the latency to enter the dark room (P<0.01). Carbamazepine significantly reduce the entrance time in intact rats and kindled rats by PTZ (P<0.05, P<0.01).

Conclusion: This study showed that the administration of Carbamazepine in seizure rats can cause the increasing learning and memory impairments in rats by Pentylenetetrazole.

Keywords: Carbamazepine, Seizure, Pentylenetetrazole, Learning, Memory, Rat

Full-Text [PDF 768 kb] (2203 Downloads)

Type of Study: Original article | Subject: Physiology
Received: 2016/01/12 | Accepted: 2016/08/6 | Published: 2016/10/2

References

1. Stoica R, Ailamaki A. Enabling efficient OS paging for main-memory OLTP databases. InProceedings of the Ninth International Workshop on Data Management on New Hardware 2013 Jun 24 (p. 7). ACM.

2. Aguiar Jr AS, Castro AA, Moreira EL, Glaser V, Santos ARS, Tasca CI, et al. Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: involvement of hippocampal plasticity via AKT, CREB and BDNF signaling. Mech Ageing Dev 2011; 132(11): 560-67.

3. Bloom F, Nelson CA, Lazerson A. Brain mind and behavior. Education broadcastion corporation, 2001, pp. 276-313.

5. Bertram E, The relevance of kindling for human epilepsy. Epilepsia 2007; 48(s2): 65-74.

6. Spencer JP. Food for thought: The role of dietary flavonoids in enhancing human memory , learning and neuro congnitive performance. Proc Nutr soc 2008; 67(02): 238-52.

7. Sener U, Zorlu Y, Karaguzel O, Ozdamar O, Coker I, Topbas M. Effects of common anti-epileptic drug monotherapy on serum levels of homocysteine, vitamin B12, folic acid and vitamin B6. Seizure 2006; 15(2): 79-85.

10. Ornoy A. Neuroteratogens in man: an overview with special emphasis on the teratogenicity of antiepileptic drugs in pregnancy. Reprod Toxicol 2006; 22(2): 214-26.

11. Hasanein P, Shahidi S. Preventive effect of Teucrium polium on learning and memory deficits in diabetic rats. Med Sci Monit 2012; 18(1): BR41-6.

12. Arboix A, Garcia-Eroles L, Oliveres M, Targa C, Balcells M, Massons J. Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia? BMC Neurol 2010; 10(1): 1.

13. Camfield P, Camfield C. Unprovoked status epilepticus: the prognosis for otherwise normal children with focal epilepsy. Pediatrics2012; 130: e501–e506.

14. Lee JK, Won JS, Singh AK, Singh I. Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death. Neurosci lett. 2008; 440(3): 260-64.

15. Goldberg AH, Gibaldi M, Kanig JL. Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II: Experimental evaluation of a eutectic mixture: Urea-acetaminophen system. working versions of the water maze. Physiol Behav, 2008; 93(3): 622-27.

16. Hiremath GK, Kotagal P, Bingaman W, Hovinga C, Wyllie E, Morris H, et al. Risk factors for carbamazepine elevation and toxicity following epilepsy surgery. Seizure 2005; 14(5): 312-17.

17. Christensen HD, Rayburn WF, Parker KM, Gonzalez CL, Gold KP. Chronic prenatal exposure to carbamazepine and perinatal outcomes of C3H/He mice. Am J Obstet Gynecol 2004; 190(1): 259-63.

18. Beach FL. 2015 ACMT Annual Scientific Meeting, March 27–29, 2015 Clearwater. J Med Toxicol 2015; 11: 2-47.

20. Balcombe JP. Laboratory environment and rodents’ behavioral needs: a review. Lab Animals 2006; 40(3): 217-35.

22. Zamani Esmati M, Malakzadeh H, Jenab Esfahani H, Eshaghabadi A, Ghasemi S, Jafarian M. The Effect of Carbamazepine on Neuronal Damage in Pentylentetrazole Model of Seizure. Neuro Sci J Shefaye Khatam 2015; 3(1): 42-8.

24. Vafaee Farzaneh, Mahmoud Hosseini, Zahra Hassanzadeh, Mohammad Amin Edalatmanesh, Hamid Reza Sadeghnia et al. The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats. Iran J Pharm Res 2015; 14(2): 547-57.

25. Mumenthaler M, Mattle H. Fundamentals of neurology: an illustrated guide.1st ed. Thieme; 2006.

26. Nassiri-Asl M, Mortazavi SR, Samiee-Rad F, Zangivand AA, Safdari F, Saroukhani S, et al. The effects of rutin on the development of pentylenetetrazole kindling and memory retrieval in rats. Epilepsy Behavior 2010; 18(1): 50-3.

28. Rostami S, Momeni Z, Behnam Rasouli M, Ghayour N. Comparison of antioxidant effect of Melissa officinalis leaf and vitamin C in lead acetate-induced learning deficits in rat. Medical Daneshvar 2010; 17: 47-54.

31. Qiao X, Sun G, Clare JJ, Werkman T, Wadman WJ. Properties of human brain sodium channel α-subunits expressed in HEK293 cells and their modulation by carbamazepine, phenytoin and lamotrigine. Br J Pharmacol 2014; 171(4): 1054-67.

32. Nekrassov V, Sitges M. Comparison of acute, chronic and post-treatment effects of carbamazepine and vinpocetine on hearing loss and seizures induced by 4-aminopyridine. Clin Neurophysiol 2008; 119(11): 2608-14.

33. Pavlov I, Walker MC. Tonic GABA(A) receptor-mediated signalling in temporal lobe epilepsy. Neuropharmacol 2013; 69: 55-61.

34. Miles R, Blaesse P, Huberfeld G, Wittner L, Kaila K. Chloride homeostasis and GABA signaling in temporal lobe epilepsy. In Jasper’s Basic Mechanisms of the Epilepsies, edn 4. Edited by Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV. Oxford Uni Press; 2012.

35. Ruusuvuori E, Huebner AK, Kirilkin I, Yukin AY, Blaesse P, Helmy M, et al. Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures. EMBO J 2013; 32(16): 2275-86.

37. Zhenyu Ren, MD, Bin Yang, MS, Le Shi, Qing-Li Sun, MD et al. Carbamazepine Withdrawal-induced Hyperalgesia in Chronic Neuropathic Pain. Pain Physician 2015; 18(6): E1127-E1130.

38. Liu L, Zheng T, Morris MJ, Wallengren C, Clarke AL, Reid CA, Petrou S, O'Brien TJ. The mechanism of carbamazepine aggravation of absence seizures, J Pharmacol Exp Ther 2006; 319(2): 790-98.

39. Huang CC, Hsu Ks. Local protein synthesis and GABA receptors regulate the reversibility of long – term potentiation at murine hippocampal mossy fiber- CA3 synapses. J physiol 2004; 561(1): 91-108.

40. Izquierdo I, Dacunha C, Rosat R. Neurotransmitter receptors involved in memory processing by the amygdale, medial septum and hippocampus of rats. Behav. And Neurobial 1992; 58: 16-26.

41. Czapinski P, Blaszczyk B, Czuczwar SJ. Mechanisms of action of antiepileptic drugs. Current Topics in Medicinal Chemistry 2005; 5: 3-14.

42. Silvia J López-Pérez. Corresponding author Alberto Morales-Villagrán, and Laura Medina-Ceja, Effect of perinatal asphyxia and carbamazepine treatment on cortical dopamine and DOPAC levels. J Biomed Sci 2015; 22(1): 14.

44. Chen CC, Shen JW, Chung NC, Min MY, Cheng SJ, Liu IY. 2012. Retrieval of context-associated memory is dependent on the Ca (v) 3.2 T-type calcium channel. PLoS One 7: e29384.

45. Palmer GC, Stagnitto ML, Ray RK, Knowels MA, Harvey R, Garske GE. Anticonvulsant properties of calcium channel blockers in mice: N-methyl-D-, Laspartate- and Bay K 8644-induced convulsions are potently blocked by the dihydropyridines. Epilepsia 1993; 34(2): 372-80.

46. Khanna N, Bhalla S, Verma V, Sharma KK. Modulatory effects of nifedipine and nimodipine in experimental convulsions. Indian J pharmacol 2000; 32: 347-52.

47. Mc Namara JO. The neurobiological basis of epilepsy. Trends Neurosci 1992; 15(10): 357-9.

48. Kriz J, Župan G, Simonić A. Differential effects of dihydropyridine calcium channel blockers in kainic acid-induced experimental seizures in rats. Epilepsy Res 2003; 52(3): 215-25.

49. Gunthorpe MJ, Large CH, Sankar R. The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy. Epilepsia 2012; 53: 412.

50. Loscher W. Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy. Prog Neurobiol 1998; 54(6): 721-41.

51. Ebrahimi HA, Ebrahimi S. Evaluation of the Effects of Charged Amino Acids on Uncontrolled Seizures 2015; Article ID 124507, 5 pages.

52. Steinhoff BJ, Ben-Menachem E, Ryvlin P, Shorvon S, Kramer L, Satlin A, et al. Efficacy and safety of adjunctiveperampanel for the treatment of refractory partial seizures:a pooled analysis of three phase III studies. Epilepsia 2013; 54: 1481-89.

53. Khan N, Shah D, Tongbram V, Verdian L, Hawkins N. Theefficacy and tolerability of perampanel and other recentlyapproved anti-epileptic drugs for the treatment of refractorypartial onset seizure: a systematic review and Bayesiannetwork meta-analysis. Curr Med Res Opin 2013; 29: 1001-13.