Introduction: Omperazole as a very useful drug in peptic ulcer which needs to be converted to active form and its activation requires acidic enviornments. H2 blockers and antacids can prevent this activation by elevation of pH in the gastrointestinal system thus diminishing omperazole effectiveness. In this study, cases of coadministration of omperazsole with H2 blockers and antiacids has been evaluated. Methods: This descriptive study included 1200 prescriptions containing omperazole alone or in combination with other drugs at the Chamran Pharmaceutical Store of Yazd. Results : In 599 cases, omeprazole was administered with other drugs of which 211 cases (35.3%) was with H2 blockers and116 prescriptions with antiacids. Only in 55 cases (4.6%), both antiacids and H2 blockers were administered in combination with omperazole. Conclusion:On the basis of previous studies and considering the physiology of acid secretion in parietal cells and pharmacological mechanism of drugs used in the treatment of peptic ulcer, coadministration of antacids and H2 blockers with omperazole decrease its efficacy and must therefore be avoided.

Keywords: Omperazole, H2 blockers, Antacids, Coadministration, Peptic ulcer

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