Volume 26, Issue 6 (Sep 2018)                   JSSU 2018, 26(6): 483-494 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Rami M, Habibi A, khajehlandi M. Effect of 6-weeks of endurance training on the activity of superoxide dismutase and glutathione peroxidase enzymes in the hippocampus of experimental diabetic male Wistar rats . JSSU. 2018; 26 (6) :483-494
URL: http://jssu.ssu.ac.ir/article-1-4588-en.html
Abstract:   (2206 Views)
Introdution:Scientific evidence suggests the role of oxidative stress in diabetes and the development of its complications. Pre-preparation by aerobic exercise with increasing antioxidant power of neuronal cells can reduce oxidative stress and increase the resistance of the hippocampal region neurons.Therefore, the purpose of this study was to investigate the effect of 6weeks of endurance training on the activity of superoxide dismutase and glutathione peroxidase enzymes in the hippocampus of experimental diabetic male Wistar rats.
Methods:In this experimental study, 24 male rats (245 ± 9.4 g) aged 10 weeks were divided into 4 groups of 6 rats each. The diabetic rats were diabetic by intraperitoneal injection of STZ. The exercise program included 6 weeks of moderate intensity endurance training. At the end of 6 weeks,the hippocampal tissue samples were extracted, 24 hours after the last training session. Descriptive one-way analysis of variance(ANOVA)was used in different group. If analysis were significant, differences between groups were estimated using Scheffe post-hoc test. Significance was defined as P≤0.0.Statistical analysis was performed using SPSS software version23.
Results:After 6 weeks of endurance training, the level of superoxide dismutase in both groups, healthy training and diabetic training, was significantly increased, and in the diabetic control group, there was a significant decrease (P<0.001). Glutathione peroxidase levels in the two groups, training and healthy control group, were significantly different compare to the diabetic control group (P≥0.05).There was no significant difference between the three groups(P≥0.05).
Conclusion:Based on the results, it can be concluded that endurance training may be effective in increasing the anti-oxidant defense of the hippocampal tissue of diabetic rats.
Full-Text [PDF 1037 kb]   (1026 Downloads)    
Type of Study: Original article | Subject: Exercise Physiology
Received: 2018/06/7 | Accepted: 2018/07/14 | Published: 2018/10/21

References
1. 1- Aronson D. Hyperglycemia and the pathobiology of diabetic complications. Adv Cardiol. 2008; 45:1–16
2. 2- American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014; 37(1): S81–90. [Persian]
3. 3- Porter KE, Riches K. The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes? Clin Sci (Lond) 2013; 125(4): 167-82.
4. 4- Hsu WT, Tsai LY, Lin SK, Hsiao JK, Chen BH. Effects of diabetes duration and glycemic control on free radicals in children with type 1 diabetes mellitus. Ann Clin Lab Sci 2006; 36(2): 174-8.
5. 5- Fisher-Wellman K, Bloomer RJ. Acute exercise and oxidative stress: a 30 year history. Dyn Med 2009; 8(1): 1-25.
6. 6- West IC. Radicals and oxidative stress in diabetes. Diabetic Medicine. 2000; 17(3): 171-80.
7. 7- Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J 2016; 24(5): 547-53.
8. 8- Abdi A, Ramezani N, Abbasi Daloie A, Ganji N. The Effect of Aerobic Training and Coriandrum Sativum Extract on Some Oxidative Stress Factors in Male Diabetic Wistar Rats. Tabari J Prev Med. Winter 2016; 2(4): 34-3. [Persian]
9. 9- Saritaş N, Uyanik F, Hamurcu Z. Effects of acute twelve minute run test on oxidative stress and antioxidant enzyme activities. African Pharmacy Pharmacol 2011 8; 5(9):1218-22.
10. 10- Maritim AC, Sanders RA, Watkins JB 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003; 17(1): 24-38.
11. 11- Sytze Van Dam P, Cotter MA, Bravenboer B, and Cameron NE. Pathogenesis of diabetic neuropathy: focus on neurovascular mechanisms. Eur J Pharmacol 2013; 719(1-3): 180-6.
12. 12- Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007; 39(1): 44-84.
13. 13- Chen X, Guo C, Kong J. Oxidative stress in neurodegenerative diseases. Neural regeneration research. 2012; 7(5):376.
15. 14- Melo A, Monteiro L, Lima RM, de Oliveira DM, de Cerqueira MD, El-Bachá RS. Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives. Oxid Med Cell Longev 2011: 1-14.
16. 15- Weinger K, Groot M, William T. Cefalu Psychosocial Research and Care in Diabetes: Altering Lives by Understanding Attitudes. Diabetes Care 2016; 39(12): 2122-25.
17. 16- Shamsaei N, Abdi H, Farzad B. The protective effect of exercise on lipid peroxidation and antioxidant enzymes activity in hippocampus following the cerebral ischemia in male rats. Sport Physiology & Management Investigations 2017; 9(3): 33-40. [Persian]
18. 17- Nakhaee H, Nazarali P, Hanachi P, Hedayati M. The effect of Aerobic Training and Cinnamon Zeylanicum Intake on Total Antioxidant Capacity in Active Women Horizon Med Sci 2018; 24(2): 88-95
19. 18- Nojima H, Watanabe H, Yamane K, Kitahara Y, Sekikawa K, Yamamoto H, et al. Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus. Metabol 2008; 57(2): 170-6.
20. 19- Albasser MM, Amin E, Lin TC, Iordanova MD, Aggleton JP. Evidence that the rat hippocampus has contrasting roles in object recognition memory and object recency memory. Behav Neurosci 2012; 126(5): 659-69.
21. 20- Vinetti G, Mozzini C, Desenzani P, Boni E, Bulla L, Lorenzetti I, et al. Supervised exercise training reduces oxidative stress and cardiometabolic risk in adults with type 2diabetes: a randomized controlled trial. Sci Rep 2015; 5: 9238.
22. 21- Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physio Res 2001; 50(6): 537-46.
23. 22- Kakkar P, B Das, P Viswanathan. A modified spectrophotometric Assay of superoxide dismutase. Indian Journal of Biochemistry & Biophysics 1984. Vol (21): 130-132.
24. 23- Chen Z, He Y, Song C, Dong Z, Su Z, Xue J. Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus. Neural regeneration research 2012; 7(3):197-201.
25. 24- Li PA, Shuaib A, Miyashita H, He QP, Siesjö BK. Hyperglycemia enhances extracellular glutamate accumulation in rats subjected to forebrain ischemia. Stroke 2000; 31(1): 183-92.
26. 25- Tsutsui H, Kinugawa S, Matsushima S, Yokota T. Oxidative stress in cardiac and skeletal muscle dysfunction associated with diabetes mellitus. J Clin Bioche Nutr 2011; 48(1): 68-71.
27. 26- Oztasan N, Taysi S, Gumustekin K, Altinkaynak K, Aktas O, Timur H, et al. Endurance training attenuates exercise-induced oxidative stress in erythrocytes in rat. Eur J Appl Physiol 2004; 91(5-6): 622-7.
28. 27- Cunha TF, Bacurau AV, Moreira JBN, Paixa˜o NA, Campos JC, Ferreira JC, et al. Exercise training prevents oxidative stress and ubiquitin proteasome system over activity and reverse skeletal muscle atrophyn heart failure. PLoS One 2012; 7(8): e41701.
29. 28- Farhangi N, Nazem F, Zehsaz F. Effect of Endurance Exercise on Antioxidant Enzyme Activities and Lipid Peroxidation in the Heart of the Streptozotocin-Induced Diabetic Rats. JSSU 2017; 24 (10): 798-809. [Persian]
30. 29- Alghadir AH, Gabr SA Anwer S, Al-Eisa E. Fatigue and oxidative stress response to physical activity in type 2 diabetic patients. Int J Diabetes Dev Ctries 2015; 36(1): 59-64. [Persian]
31. 30- Hamakawa M, Ishida A, Tamakoshi K, Shimada H, Nakashima H, Noguchi T, et al. Repeated short-term daily exercise ameliorates oxidative cerebral damage and the resultant motor dysfunction after transient ischemia in rats. J Clin Biochem Nutr 2013; 53(1): 8-14.
32. 31- Laufs U, Werner N, Link A, Endres M, Wassmann S, JürgensK, et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation 2004; 109(2): 220-26.
33. 32- Pereira AdS, Spagnol AR, Luciano E, Leme JACdA. Influence of aerobic exercise training on serum markers of oxidative stress in diabetic rats. J Physical Education 2016; 27(3): 20-9.
34. 33- Pilch W, Szygula Z, Tyka AK, Palka T, Tyka A, Cison T, et al. Disturbances in pro-oxidant-antioxidant balance after passive body overheating and after exercise in elevated ambient temperatures in athletes and untrained men. PloS one 2014; 9(1): 85320.
35. 34- Aksoy Y, Yapanoğlu T, Aksoy H, Demircan B, Öztaşan N, Canakci E, Malkoc I. Effects of endurance training on antioxidant defense mechanisms and lipid peroxidation in testis of rats. Archives of andrology 2006; 52(4): 319-23.
36. 35- Ogonovszky H, Sasvári M, Dosek A, Berkes I, Kaneko T, Tahara S, et al. The effects of moderate, strenuous, and overtraining on oxidative markers and DNA repair in rat liver. Can J Appl physiol 2005; 30(2): 186-95.
37. 36- Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature 2000; 9; 408(6809): 239-47.
38. 37- Wei D, Zhang XL, Wang YZ, Yang CX, Chen G. Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy. Aust Dent 2010; 55(1):70-8.

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


© 2021 All Rights Reserved | SSU_Journals

Designed & Developed by : Yektaweb