Volume 26, Issue 5 (Agu 2018)                   JSSU 2018, 26(5): 385-392 | Back to browse issues page

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Sheikhi J, Akram A, Namvar Amirmorteza E. Evaluation of CTX-M1 and CTX-M15 genes among Klebsiella pneumoniae isolated strains from hospitalized patients in Babol’s Hospitals . JSSU. 2018; 26 (5) :385-392
URL: http://jssu.ssu.ac.ir/article-1-4422-en.html
Abstract:   (135 Views)
Introduction: In the recent decades, the prevalence of Klebsiella pneumoniae beta-lactamase producing strains has a significant role in nosocomial infections. The aim of this study was to determine the prevalence of different types of CTX-M enzymes among clinical isolates of K. pneumoniae.
Methods: In this descriptive cross-sectional study, during six months, K. pneumoniae strains were isolated from laboratory ward of Babol educational hospitals and referred to microbiology laboratory of Babol University of Sciences for final confirmation. Thereafter, antibiogram pattern analysis and the frequency of CTX-M1 and CTX-M15 genes were evaluated. Finally, the results were analyzed by SPSS version 24 software.
Results: During six months of this study in 2017, 65 K. pneumoniae and also other bacterial strains such as Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii were collected from laboratory ward of Shahid Beheshti and Ayatollah Rouhani Hospitals. By disc diffusion method, the highest resistance belonged to Amoxicillin (91%), Cefoxitin (45%), Piperacillin (45%) and the lowest belonged to Amikacin (24%) and Imipenem (0%). On the other hand, the percentage of CTX-M1 and CTX-M15 genes were also found to be 62% and 69%, respectively.
Conclusion: Regarding to the high prevalence of strains containing broad-spectrum beta-lactamase enzymes and due to the antibiotic resistance among K. pneumoniae strains isolated from clinical specimens and also by considering this issue that the current study was the first research for evaluating the frequency of these genes in Babol educational hospitals therefore, it is necessary to adopt appropriate drug regimens to reduce antibiotic resistances
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Type of Study: Original article | Subject: Microbiology
Received: 2017/12/25 | Accepted: 2018/01/20

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