The effect of high intencity interval training combined with curcumin supplementation on Plasma glucose concentration and insulin resistance in diabetic rats

Akbarzadeh, Ali; Fattahi bafghi, Abbas

Volume 25, Issue 12 (Feb 2018) JSSU 2018, 25(12): 961-969 | Back to browse issues page

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Akbarzadeh A, Fattahi bafghi A. The effect of high intencity interval training combined with curcumin supplementation on Plasma glucose concentration and insulin resistance in diabetic rats. JSSU 2018; 25 (12) :961-969
URL: http://jssu.ssu.ac.ir/article-1-4261-en.html

The effect of high intencity interval training combined with curcumin supplementation on Plasma glucose concentration and insulin resistance in diabetic rats

Ali Akbarzadeh

, Abbas Fattahi bafghi ^*

Abstract: (4458 Views)

Introduction: Diabetes mellitus is a common condition that is recommended for the treatment and control of various therapies, such as the use of natural drugs and inactivity reduction.It has been reported exercise and herbs can possess synergistic effects to control diabetes side-effects. The purpose of the present study was investigation of the effects of high-intensity interval training and taking curcumin supplement on Concentration of glucose and insulin resistance, in diabetic rats.

Methods: In a clinical trial Thirty-two male Wistar rats were randomly divided to four groups of curcumin, training, training- curcumin, and control. The subjects had being trained to perform high-intensity interval training on treadmill and in the fashion of increasing manner. Diabetes was induced via injection of 50 (ml/Kg rat weight) STZ. Fifty (ml/kg rat weight) curcumin had being nourished to the animals of the curcumin groups, by using the gavage technique, during a period of eight weeks (five days a week). The rats were anesthetized via intraperitoneal injection of ketamine, 24 hrs after the intervention. Then, The blood was taken from the heart of the rats to examine changes glucose and insulin resistance.
Resultus: Concentration level of glucose and insulin resistance of the three groups of curcumin, training-placebo, and training-curcumin decreseded significantly than correspondent levels of the control group(P≤0.05). Though, no significant difference was observed, between those three groups (P≤0.05).

Conclusion :The results of the present study have indicated that Despite the significant effect of training and curcumin Concentration  of glucose and  insulin resistance, but those two interventions  would not strengthen the influences of each other

Keywords: high intensity interval training, curcumin supplement, Plasma glucose, insulin resistance

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Type of Study: Original article | Subject: Exercise Physiology
Received: 2017/07/24 | Accepted: 2017/12/2 | Published: 2018/04/7

References

1. 1- Blake G, Ridker P. Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med 252 (4): 283-94.

2. 2- Martins R, Verissimo M, Coelho E, silva M, Cumming S, Teixeira A. Effects of aerobic and strength-based training on metabolic health indicators in older adults. Lipids Health Dis 2010; 9(1): 76.

3. 3- Torros M, Canal J, Perez. Oxidative stress in normal and diabetic rats. Physiol Res 1999; 48(3): 203-8.

4. 4- Aicher B, Haser E, Freeman L, Carnie A, Stonik J, Wang X. Diet-induced weight loss in overweight or obese women and changes in high-density lipoprotein levels and function. Obesity (Silver Spring) 2012; 20(10): 2057-62.

5. 5- Foster DW. Diabetes mellitus.Harrison Tensely Randolph. Harrisson's principle of internal med 1998: 2060-80.

6. 6- Stewart KJ. Exercise training: can it improve cardiovascular health in patients with type 2 diabetes. Br J SportsMed 2018; 38: 250- 52.

7. 7- Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol 2007; 595: 1-75.

8. 8- Kuhad A, Chopra K. Curcumin attenuates diabetic encephalopathy in rats: Behavioral and biochemical evidence. Eur J Pharmacol 2007; 576 (1-3): 34-42.

9. 9- Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.

10. 10- Gibala MJ, Little JP, Macdonald MJ, Hawley JA. Physiological adaptations to low-volume,high-intensity interval training in health and disease. J Physiol 2012; 590 (5): 1077-84.

11. 11- Perry CG, Heigenhauser GJ, Bonen A, Spriet LL. Highintensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle. Appl Physiol Nutr Metab 2008; 33: 1112-23.

12. 12- Helgerud J, Hoydal K, Wang E, Karlsen T, Berg P, Bjerkaas M, et al. Aerobic high-intensity intervals improve VO2max more than moderate training. Med Sci Sports Exer 2007; 39(4): 665-71.

13. 13- Buetiner G. The peaking order of free radicals and antioxidant, Lipid peroxidation alpha tocropherol and ascorbate. J Arch Biochemistry Bio 1993; 30(2): 535-43.

14. 14- Trapp EG, Chisholm DJ, Freund J, Boutcher SH. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond) 2008; 32(4): 684-91.

15. 15- King J, Broeder C, Browder K, Panton L. A comparison of interval vs steady-state exercise on substrate utilizeation in overweight women. Med Sci Sports Exerc 2002; 34(5): 228-32.

16. 16- Aveseh M, Nikooie R, Sheibani V. Effect of Eight Weeks of Endurance Training on Brain Lactate Uptake of Diabetic Rats During Hypoglycemia State. AMUJ 2014; 17(5) :1-10

17. 17- Shirwaikar A, Rajendran K, Barik R. Effect of aqueous bark extract of GarugapinnataRoxb. Instreptozotocinnicotinamide induced type-II diabetes mellitus. J Ethnopharmacol 2006; 107(2): 285–90.

18. 18- Fathi r, Talebi A, Safarzadeh A, Seighal H. Effect Of 8-week resistance training on plasma visfatin levels and its relation to insulin resistance in insulin-resistannt male rats. Iranian J Diabet Metabolism 2015; 14(6): 390-98. [Persion]

19. 19- Gupta SK, Kumar B, Nag TC, Agrawal SS, Agrawal R, Agrawal P, et al. Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms. J Ocul Pharmacol Ther 2011; 27(2): 123-30.

20. 20- El-Azab MF, Attia FM, El-Mowafy AM. Novel role of curcumin combined with bone marrow transplantation in reversing experimental diabetes: Effects on pancreatic islet regeneration, oxidative stress, and inflammatory cytokines. Eur J Pharmacol 2011; 658(1):41-8.

21. 21- Na LX, Zhang YL, Li Y, Liu LY, Li R, Kong T, et al. Curcumin improves insulin resistance in skeletal muscle of rats. Nutr Metab Cardiovasc Dis 2011; 21(7): 526-33.

22. 22- Patumraj S, Wongeakin N, Sridulyakul P, Jariyapongskul A, Futrakul N, Bunnag S. Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats. Clin Hemorheol Microcirc 2006; 35(4): 481-9.

23. 23- Liu Q, Wang S, Cai L. Diabetic cardiomyopathy and its mechanisms: Role of oxidative stress and damage. J Diabetes Investig 2014; 5(6): 623-34.