Volume 25, Issue 5 (Jul-Aug 2017)                   JSSU 2017, 25(5): 404-413 | Back to browse issues page

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Karimi Arab M, Heidarieh N, Jamalloo F. Effect of Hydroalchoholic Extract Sumac (Rhus coriaria L.) on Expression of Passive Avoidance Learning in Gonadectomized Male Rats. JSSU. 2017; 25 (5) :404-413
URL: http://jssu.ssu.ac.ir/article-1-4077-en.html

Abstract:   (404 Views)
Introduction: Learning and memory is characteristically human to survive; reducing sexual hormones in aging and the side effects of chemical drugs are factors that can cause memory and learning disruption. In this study the effect of hydroalchoholic extract sumac (Rhus coriaria L.) on expression passive avoidance learning in gonadectomized male rats was studied.
Methods: In this experimental study, 32 adult Wistar rats with a weight of 230±20 were put in four groups (8 rats per group), including: received healthy solvent extract Dimethyl sulfoxide (DMSO), gonadectomized received of DMSO and doses of 25 and 50 mg/ kg extract sumac . Firstly, , rats injected intraperitoneally with ketamine (75 mg/kg) and xylazine (10 mg/kg) anesthesia, gonads removed after 15 days recovery period, extensive testing. Passive avoidance test by the Shuttle box device after treatment by the same conditions was performed for all groups. All treatment was performed intraperitoneally and a half hours before the test on the second day (check expression).The data were analyzed by the one-way ANOVA and Tukey test (P<0.05).
Results: Results showed that in the gonadectomized group received solvent extract (DMSO) (3/0 cc) a significant reduced was found in latency to enter the dark room compared to DMSO control groups (P <0.001). The groups The groups receiving the extract sumac(Rhus coriaria L.)  at a doses of 50 and 25 mg / kg showed a significant increase in latency in the dark room compared with the group receiving the gonadectomy receiving DMSO(P<0.05).
Conclusion: Results show that the gonadectomy reduces the incidence of avoidance learning and In gonadectomized rats, hydroalcoholic extract of sumac increases the incidence of passive avoidance learning.
Full-Text [PDF 805 kb]   (88 Downloads)    
Type of Study: Original article | Subject: Physiology
Received: 2017/01/20 | Accepted: 2017/07/25 | Published: 2017/10/4

1. Mukherjee D, Banerjee S. Learning and memory promoting effects of crude garlic extract. Indian J Experimental Biology 2013; 51: 1094-1100.
2. Dimitrova D, Getova D. Effects of rivastigmine on learning and memory processes in rats active avoidance test. Science & Technologies 2014; 4(1): 35-39.
3. Uddin MdS, Mamun AA, Hossain S, Ashaduzzaman M, Asif Noor A, Hossain S, et al. Neuroprotective Effect of Phyllanthus acidus L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease. Advances in Alzheimer’s Disease 2016; 5(2): 53-72.
4. Yang Q, Wang Y, Feng J, Cao J, Chen B. Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: The potential roles played by microglia. Neuropsychiatr. Dis Treat 2013; 9: 1077–86.
5. Hallowell B, Aeschbach R, Loliger J, Aruoma OI. The characterization of antioxidants, Food Chem. Toxicol 1995; 33(7): 601-17.
6. Hasasna Hel, Athamneh K, Al Samri H, Karuvantevida N, Al Dhaheri H, Hisaindee S, et al. Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation. Sci Rep 2015; 5: 13013.
7. Abu-Reidah IM, Ali-Shtayeh MS, Jamous RM, Arráez-Román D, Segura-Carretero A. HPLC-DAD-ESI-MS/MS screening of bioactive components from Rhus coriaria L. (Sumac) fruits. Food Chem 2015; 166: 179–191.
8. Mozdastan S, Ebrahimzadeh M A, Khalili M. Comparing the Impact of Different Extraction Methods on Antioxidant Activities of Myrtle (Myrtus communis L.). J Mazandaran Uni Med Sci 2015; 25(127) :10-24. [Persian]
9. Khalili M, Ebrahimzadeh MA. A review on antioxidants and some of their common evaluation methods. J Mazandaran Uni Med Sci 2015; 24(120):188-208. [Persian]
10. Moini F, Mohammadi Sichani M, Shahanipoor K. The Antibacterial effect of methanol and aqueous extracts of vaccinium arctostaphylos fruit on enteropathogenic Escherichia coli in vitro. Qom Univ Med Sci J 2016; 9(12): 16-24.
11. Balcombe JP. Laboratory environment and rodents’ behavioral needs: a review. Laboratory animals 2006; 40(3): 217-35.
12. Salimi ZR, Headari R, Nejati A, Eskandary , Ghasemi Z. Effect of aqueous extract of sumac (Rhus coriaria L.) on the level of blood glucose and serum lipids in diabetic rats. Iranian J M and Aromatic Plants 2015; 30(6): 843-51.
13. Neufeld KM, Kang N, Bienenstock J, Foster JA. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 2011; 23(3): 255-64
14. Emami M, Hosseini A, Saeedi A, Golbidi D, Reisi P, Alaei H. Effect of red grape juice on learning and passive avoidance memory in rats. J Isfahan Medical school 2010; 104(28):1-8.
15. Salimi Z, Headari R, Nejati V, Eskandary A. Protective effects of aqueous extracts of sumac(Rhus coriaria L.)on Catalase activity and liver Histopathology in diabetic rats with Alloxan. J Qom Uni Med Sci 2012; 6(2): 45-52. [persion]
16. Kehr J, Yoshitake S, Ijiri S, Koch E , Nöldner M, Yoshitake T. Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761®. International Psy 2012; 24(1): 25–34.
17. Kumar NS, Mukherjee PK, Bhadra S, Saha BP, Pal BC. Acetylcholinesterase inhibitory potential of a carbazole alkaloid, mahanimbine from Murraya koenigii. Phytotherapy Res 2010; 24(4): 629-31.
18. Fakhri-Bafghi MS, Ghasemi-Niri SF, Mostafalou S, Navaei-Nigjeh M, Baeeri M, Mohammadirad A, et al. Protective effect of selenium-based medicines on toxicity of three common organophosphorus compounds in human erythrocytes in vitro. Cell J 2016; 17(4): 740-47.
19. Reigstad CS, Salmonson CE, Rainey JF, Szurszewski JH, Linden DR, Sonnenburg JL, Farrugia G, Kashyap PC. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB J 2015; 29(4): 1395–1403.
20. Crane JD, Palanivel R, Mottillo EP, Bujak AL, Wang H, Ford RJ, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat. Med 2015; 21(2): 166–172.
21. Dai J, Mumper RJ. Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Mol 2010; 15(10): 7313-52.
22. Heydarifar S, Ilkhanipour M, Farokhi F, Mohammadzadeh M. The Effect of Lorazepam and Aqueous Extract of Melissa officinalis on Histological Changes in the Hippocampus and Spatial Memory in Male Rats. Qom Univ Med Sci J 2016; 10(4) :10-21.
23. Tomaz VS, Cordeiro RC, Costa AM, de Lucena DF, Nobre Junior HV, de Sousa FC, et al. Antidepressant-like effect of nitric oxide synthase inhibitors and sildenafil against lipopolysaccharide-induced depressive-like behavior in mice. Neuroscience 2014; 268: 236–46.
24. Ghaffari MA, Aberumand M, Roshanmehr H, Hosseini SA. Reduction of High Glucose-Induced Nitric Oxide Synthase Expression in Human Vascular Endothelial Cells by Ascorbic Acid and α-Tocopherol. Int J Pharm Res Allied Sci 2016; 5(2):135-143. [persion]
25. Tuo K, Béourou S, Touré AO, Ouattara K, Meité S, Ako Ako AB, et al. Antioxidant activities and estimation of the phenols and flavonoids content in the extracts of medicinal plants used to treat malaria in Ivory Coast. Int J Curr Microbial App Sci 2015; 4(1): 862-74.
26. Uddin MS, Sarker M, Islam Z, Ferdosh S, Akanda M, Haque J, et al. Phytosterols and their extraction from various plant matrices using supercritical carbon dioxide: A review. J Sci Food Agric 2015; 95(7): 1385–94.
27. Vidak M, Rozman D, Komel R. Effects of Flavonoids from Food and Dietary Supplements on Glial and Glioblastoma Multiforme Cells. Molecules 2015; 20(10): 19406-432.
28. Tolba EAHT. Dietary phytoestrogens reduce the leptin level in ovariectomized female rats. International J Chemical, Environmental & Biological Sci 2013; 1: 2320-4079.
29. Aliabadi A, Izadi M, Rezvani MA. Effects of Thymol on Serum Biochemical and Antioxidant Indices in Kindled Rats. Inter J Med Lab 2016; 3(1): 43-9. [persion]
30. Nikousaleh A, Prakash J. Antioxidant Properties of Selected Spices Used in Iranian Cuisine and Their Efficacy in Preventing Lipid Peroxidation in Meat Sausages. J Agr Sci Tech 2016; 18(1): 67-78.

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