Volume 24, Number 8 (Nov 2016) | JSSU 2016, 24(8): 649-658 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bagheri M, Razavi-Ratki S, Nafisi-Moghadam R, Jelodari M, Parach A. The Estimation of 99mtc DMSA Absorbed Dose in Renal Scintigraphy of Pediatric Patients Using MIRDOSE Software and Planar/SPECT Hybrid Method. JSSU. 2016; 24 (8) :649-658
URL: http://jssu.ssu.ac.ir/article-1-3851-en.html

Abstract:   (565 Views)

Introduction: 99mTc–Dimercaptosuccinic Acid (DMSA) as evaluation of pediatric genitourinary abnormalities has an important role in pediatric nuclear medicine. The aim of this study was to estimate organs absorbed dose for children injected by 99mTc DMSA using MIRDOSE software and hybrid planar/SPECT method.

Methods: After injection of 99mTc-DMSA, ten children with genitourinary abnormalities underwent 3-5 planar scans and single SPECT scan (at 1 to 20 h post injection). Also for anatomical reference of patients’ organs, MRI scans were performed for each patient. A hybrid planar/SPECT method was used to plot time activity curves for obtain source organs cumulated activity and then to calculate obserbed doses of organs MIRDOSE software was used.

Results: Mean absorbed dose due to 99mTc-DMSA in pediatric for kidneys (200 ± 160), adrenals (15.1 ± 9.5), urinary bladder wall (14.7 ± 9.8), spleen (12.7 ± 7.8), gonads (12.4 ± 11.2), pancreas (10.5 ± 6.2), gall bladder wall (9.8 ± 5.7) , , , , , micro Sivert per MegaBequrel, respectively. Also, the mean effective doses was 10.01 ± 6.03 µSv/MBq.

Conclusion: The difference between the radiation doses received by the various organs of the patients caused by different amounts of radiopharmaceutical uptake in organs for different patients. Image quantities practical method using planar/SPECT hybrid method can be utilized with acceptable accuracy in determination of cumulative activity.

Full-Text [PDF 1506 kb]   (281 Downloads)    
Type of Study: Original article | Subject: Medical Physics
Received: 2016/08/15 | Accepted: 2016/11/5 | Published: 2017/01/1

1. 1- Lythgoe KEMF, Anderson PJ, Smith T, Gordon I. Biokinetic Behavior of Technetium—99m-DMSA in Children. J Nucl Med 1996; 37: 1331-35.
2. Sfakianakis GN, Cavagnaro F, Zilleruelo G, Abitbol C, Montane B, Georgiou M, et al. Diuretic MAG3 scintigraphy (F0) in acute pyelonephritis: regional parenchymal dysfunction and comparison with DMSA. J Nuclear Med 2000; 41(12): 1955-63.
3. Treves ST, Baker A, Fahey FH, Cao X, Davis RT, Drubach LA, et al. Nuclear medicine in the first year of life. J Nuclear Med 2011; 52(6): 905-25.
4. Sgouros G, Frey EC, Bolch WE, Wayson MB, Abadia AF, Treves ST. An approach for balancing diagnostic image quality with cancer risk: application to pediatric diagnostic imaging of 99mTc-dimercaptosuccinic acid. J Nuclear Med 2011; 52(12): 1923-29.
5. Eberlein U, Bröer JH, Vandevoorde C, Santos P, Bardiès M, Bacher K, et al. Biokinetics and dosimetry of commonly used radiopharmaceuticals in diagnostic nuclear medicine–a review. European J Nuclear Med and molecular imaging 2011; 38(12): 2269-81.
6. Shahbazi-Gahrouei D, Nikzad S. Determination of organ doses in radioiodine therapy using medical internal radiation dosimetry (MIRD) method. Iran J Radiat Res 2011; 8(4): 249-52.
7. Grimes J, Celler A. Comparison of internal dose estimates obtained using organ-level, voxel S value, and Monte Carlo techniques. Medical physics 2014; 41(9): 092501.
8. Grimes J, Celler A, Birkenfeld B, Shcherbinin S, Listewnik MH, Piwowarska-Bilska H, et al. Patient-specific radiation dosimetry of 99mTc-HYNIC-Tyr3-octreotide in neuroendocrine tumors. J Nuclear Med 2011; 52(9): 1474-81.
9. Matthay KK, Panina C, Huberty J, Price D, Glidden DV, Tang HR, et al. Correlation of tumor and whole-body dosimetry with tumor response and toxicity in refractory neuroblastoma treated with 131I-MIBG. J Nuclear Med 2001; 42(11): 1713-21.
10. Wiseman GA, Kornmehl E, Leigh B, Erwin WD, Podoloff DA, Spies S, et al. Radiation dosimetry results and safety correlations from 90Y-ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory non-Hodgkin’s lymphoma: combined data from 4 clinical trials. J nuclear Med 2003; 44(3): 465-74.
11. Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nuclear Med 2005; 46(6): 1023-7.
12. Momennezhad M, Nasseri S, Zakavi SR, Parach AA, Ghorbani M, Asl RG. A 3D Monte Carlo Method for Estimation of Patient-specific Internal Organs Absorbed Dose for 99mTc-hynic-Tyr3-octreotide Imaging. World J nuclear Med 2016; 15(2): 114.
13. Obrzut SL, Koren AO, Mandelkern MA, Brody AL, Hoh CK, London ED. Whole-body radiation dosimetry of 2-[18 F] Fluoro-A-85380 in human PET imaging studies. Nuclear Med Bio 2005; 32(8): 869-74.
14. Marcatili S, Villoing D, Mauxion T, McParland B, Bardiès M. Model-based versus specific dosimetry in diagnostic context: Comparison of three dosimetric approaches. Med physics 2015; 42(3): 1288-96.
15. Prideaux AR, Song H, Hobbs RF, He B, Frey EC, Ladenson PW, et al. Three-dimensional radiobiologic dosimetry: Application of radiobiologic modeling to patient-specific 3-dimensional imaging–based internal dosimetry. J Nuclear Med 2007; 48(6): 1008-16.
16. Siegel JA, Thomas SR, Stubbs JB, Stabin MG. MIRD pamphlet no. 16: techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates. J Nuclear Med 1999; 40(2): 37S.
17. He B, Wahl RL, Sgouros G, Du Y, Jacene H, Kasecamp WR, et al. Comparison of organ residence time estimation methods for radioimmunotherapy dosimetry and treatment planning—patient studies. Med physics 2009; 36(5): 1595-1601.
18. Parach AA, Rajabi H, Askari MA. Paired organs—Should they be treated jointly or separately in internal dosimetry? Med physics 2011; 38(10): 5509-21.
19. Smith T, Evans K, Lythgoe MF, Anderson PJ, Gordon I. Radiation Dosimetry of Technetium-99m—DMSA. J Nucl Med 1996; 37: 1336-42.
20. Mattsson S. Patient dosimetry in nuclear medicine. Radiation protection dosimetry 2015: ncv061.

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author

© 2015 All Rights Reserved | SSU_Journals

Designed & Developed by : Yektaweb