Volume 24, Issue 5 (Aug 2016)                   JSSU 2016, 24(5): 409-420 | Back to browse issues page

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Abstract:   (4449 Views)

Introduction: After cardiovascular disease and cancer, stroke is the third most common cause of death in the most industrialized countries. The aim of study was assessment of relationship between the effect of Boswelliaserrata aqueous extracts infarct volume in rat stroke model.

Methods: Five groups, each consisting of 7 male wistar rats, were studied. The groups consisting of control, sham and three treatment groups received aqueous extracts Boswelliaserrata for 30 days (50,100 and 150mg/kg day, respectively). The control group received distilled water, while in ischemia induction and sham group they did not receive distrill water. Two hours after the last gavaged dose, overly group with 7 pieces operated for measurement of amount of infarct volume and neurologic deficits. (Middle Cerebral Artery Occlusion Model). The data were analyzed via ANOVA test.

Results: In comparison to the ischemia group, pre- treatment aqueous extracts Boswelliaserrata with the doses of 100 and 150 mg/kg body weight indicated a meaningful difference. In addition, median score of neurological violation was significantly reduced through aqueous extracts Boswelliaserrata consumption in the doses of 100 and 150 mg/kg body weight, compared to the ischemia group.

Conclusion:According to this study, aqueous extracts of Boswelliaserrata can reduce the amount of tissue damage caused by stroke and neurological protection.

Full-Text [PDF 568 kb]   (1920 Downloads)    
Type of Study: Original article | Subject: Physiology
Received: 2016/01/25 | Accepted: 2016/05/14 | Published: 2016/10/5

1. 1- Thorvaldsen P, Asplund K, Kuulasmaa K, Rajakanges AM, Schroll M. Stroke incidence, case fatality, and mortality in WHO MONICA project. World Health Organization Monitoring Trends and Determinants in Cardiovascular Disease. Stroke 1995; (3): 361-67.
2. 2- Shaheen EL, Annette K, Magdalena H. Inflammatory mechanisms in ischemic stroke: Therapeutic approaches. J Transl Med 2009; 7(1): 97-108.
3. 3- Astrup J, Siesjo BK, Symon L. Thresholds in cerebral ischemia- The ischemic penumbra. Stroke 1981; 12(6): 723-25.
4. 4- Bechman JS, Beckman TW, Chen J, Marshall PA, Freeman BA. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Ntl Acad Sci USA 1990; 87(4): 1620-24.
5. 5- Margaill I, Plotkine M, Lerouet D. Antioxidant strategies in the treatment of stroke. Free Rdic Biol Med 2005; 39(4): 429-43.
6. 6- Rafieian-Kopaie M, Baradaran A, Rafieian M. Plants antioxidants: From laboratory of clinic. J Nephropathol 2013; 2(2): 152-53.
7. 7- Middleton EJR, Kandaswarni C, Theoharides TC. The effects of plant Flavonoids on Mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacological Rev 2000; 52(4): 673-751.
8. 8- Hosseinpour M, Mobini- Dehkordi M, Saffar S, Teymuri T. Antiproliferative effects of Matricaria chamomilla on saccharomyces cerevisiae. J Herb Med Pharmacol 2013; 2(2): 49-51.
9. 9- Rafieian- Kopaei M, Baradaran A, Rafieian M. Stress and the paradoxical effects of antioxidants. J Med Sci 2013; 18(7): 629.
10. 10- Rafieian- Kopaei M. Medicinal plants and the human needs. J Herb Med Pharmacol 2012; 1: 1-2.
11. 11- Baradaran A, Rbiei Z, Rafieian M, Rafieian M, Shirzad H. A review study medicinal plants affecting amnesia through cholinergic system. J Herb Med Pharmaco 2012; 1(1): 3-9.
12. 12- Kulkarni RR, Patki PS, Jog VP, Gandage S, Gand Patwadhan B. Treatment of osteoarthritis with a herbomineral formulation: a double-blind, placebo- controlled, crossover study. J Ethno Pharmaco 1991; 33(1-2): 91-5.
15. Assimo Poulou AN, Zlatanos SN, Papageorgiou VP. Antioxidant activity of natural resins and bioactive triterpenes in oil substrate. .Food Chem 2005; 92(4): 721-27.
16. Behnamrasuli M, Hoseinzadeh H, Ghafarimoghadam G. Empowering effect of frankincense extract on memory. Tarbiat Moalem Univ J of Sci 2001; 1-14.
17. Poeckel D, Werz O. Boswellic acids: biological actions and molecular targets. Curr Med Chem 2006; 13(28): 3359-69.
18. Rall B, Ammon HP, Safayhi H. Boswellic acids and protease activities. Phytomedicine 1996; 3(1): 75-6.
19. Singh GB, Atal CK. Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new nonsteroidal anti-inflammatory agent. Agents Action 1986; 13: (3-4): 407-12.
20. Al- Awadi F, Fatania H, Shamate U. The effect of plants mixture extract on liver gluconeogenesis in streptozocin induced diabetic rats. Diabetes Res 1991; 18(4): 163-68.
21. Yassin NA, El-Shenawy SM, Mahdy KA, Gouda NA, Marrie AE, Farrag AR. Effect of Boswellia serrata on Alzheimer’s disease induced in rats. J Arab Soc Med Res 2013; 8: 1–11.
22. Kavitha JV, Rosario JF, Chandran J, Anbu Pand B. Hypoglycemic and other related effects of Boswellia glabra in alloxan induced diabetic rats. Indian J Physiol Pharmaco 2007; 51(1): 29-31.
23. Zaker SR, Beheshti S, Aghaie R, Noorbakhshnia M. Effect of olibanum on a rat model of Alzheimer’s disease induced by intracerebroventricular injection of streptozotocin. Physio Pharmaco 2015; 18(4): 477-89. [Persian]
24. Sadeghi F, Khalaj-Kondori M, Hosseinpour Feizi MA, Shaikhzadeh Hesari F. The effect of Aqueous extract of Boswellia on learning and spatial memory in adult male rats. ZUMS J 2014; 22(95): 122-31. [Persian]
25. Ding Y, Chen M, Wang M, Zheng T, Park J, Zhu Y, et al. Neuroprotection by acetyl-11-keto-β-Boswellic acid, in ischemic brain injury involves the NRF2/HO-1 defense pathway. Sci Rep 2014; 11(4): 7002.
26. Sadeghi F, Khalaj-Kondori M, Hosseinpour Feizi MA, Shaikhzadeh Hesari F. The effect of aqueous extract of Boswellia on learning and spatial memory in adult male rats. Zums J 2014; 22(95): 122-31. [Persian]
27. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989; 20(1): 84-91.
28. Vakili A, Khorasani MZ. Effect of aminoguanidine on Post- ischemic damage in rodent model of stroke. Park J Pharm Sci 2008: 24-8.
29. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986; 17(3): 472-6.
30. Faure S, Oudart N, Javellaud J, Fournier A, Warnock DG, Achard JM. Synergistic protective effects of erythropoietin and olmesartan on ischemic stroke survival and post- stroke memory dysfunction in the gerbil. J Hypertens 2006; 24(1): 2255-61.
31. Dattner AM. From medical herbalism to phytotherapy in dermatology: back to future. Dermatol Ther 2003; 16(2): 106-13.
32. Asadi SY, Parsaei P, Karimi M, Ezzati S, Zamiri A, Mohammadizadeh F, et al. Effect of green tea (Camellia sinensis) extract on healing process of surgical in rat. Int J Surg 2013; 11(4): 3327-27.
33. Asgary S, Keshvari M, Sahebkar A, Hashemi M, Rafieian- Kopaei M. Clinical investigation of the acute effects of Pomegranate juice on blood pressure and endothelial in hypertensive individuals. ARYA Atheroscler 2013; 3(6): 326-31.
34. Doyle KP, Simon RP, Stenzel- Poore MP. Mechanisms of ischemic brain damage. Neuropharmaco 2008; 55(3): 310-18.
35. Segura T, Calleja S, Jordan J. Recommendations and treatment strategies for the management of acute ischemic stroke. Expert Opin Pharmacother 2008; 9(7): 1071-85.
36. Zheng YQ, Liu JX, Wang JN, Xu L. Effects of Crocin on reperfusion- induced oxidative/ nitrative injury to cerebral microvessels after global cerebral ischemia. Brain Res 2007; 1138: 86-94.
37. Saleem S, Ahmad M, Ahmad AS, Yousuf S, Ansari MA, Khan MB, et al. Effect of Saffron( Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Med Food 2006; 9(2): 246-53.
38. Nijveldt RJ, van Nood E, van Hoorn DE, Boelens PG, van Norren K, van Leeuwen PA. Flavonoids: a review of probable mechanisms of action and potential applications. J Clin Nutr 2001; 74(4): 418-25.
39. Gupta I, Parihar A, Malhotra P, Singh GB, Ludtke R, Safayhi H, et al. Effects of Boswellia serrate gum resin in patients with ulcerative colitis. Eur J Med Res 1997; 2(1): 37-43.
40. Takada Y, Ichikawa H, Badmaev V, Aqqarwai BB. Acetyl-11-keto-beta-Boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-Kappa B and NF- Kappa B- regulated gene expression. J Immunol 2006; 176(5): 3127-40.
41. Chaudhary G, Sinha K, Gupta YK. Protective effect of exogenous administration of α- tocopherol in middle cerebral artery occlusion model of cerebral ischemia in rats. Fundom Clin Pharmaco 2003; 17(6): 703-07.
42. Peter Lipton. Ischemic cell death in brain neurons. Phsiol Rev 1999; 79(4): 1431-568.
43. Noghuchi N, Niki E. Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drug for atherosclerosis. Free Red Bio Med 2000; 28(10): 1538-46.
44. Frankel EN. Recent advances in lipid oxidation. J Sci Food Agric 1999; 37(4): 1027-38.
45. 43- Kumaran A, Karunakaran RJ. Antioxidant and free radical scavenging activity of an aqueous extract of Coleus armaticus. Food Chemistry 2006; 97(1): 109-14.
46. 44- Coyle JT, Puttfarcken P. Oxidative stress, glutamate, and neurodegenerative disorders. Sci 1993; 262(5134): 689-95.
47. 45- Hrtmann RM, Morgan Martins MI, Tieppo J, Fillmann HS, Marroni NP. Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid. Did Dis Sci 2012; 57(8): 2038-44.
49. Arieh M, Neta R, Tatiana B, Alex S, Christian CF, Shai S, et al. Incensole acetate, an incense component, elicits phychoactivity by activating TRPV3 channels in the brain. FASEB J 2008; 22(8): 3024-34.
50. Catanzaro D, Rancan S, Orso G, Dall Acqua S, Brun P, Giron MC, et al. Boswellia serrata preserves intestinal epithelial barrier from oxidative and inflammatory damage. PLOS One 2015; 10(5): e0125375.
51. Kirste S, Treier M, Wehrle SJ, Becker G, Abdel- Tawab M, Gerbeth K, et al. Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo- controlled, double- blind pilot trial. Cancer 2011; 117(16): 3788-95.
52. Jalili C, Salahshoor MR, Moradi S, Pourmotabbed A, Motaghi M. The therapeutic effect of the aqueous extract of Boswellia serrata on the learning deficit in kindled rats. Int J Prev Med 2014; 5(5): 563-68.