Introduction: Adipose tissue as a gland, secreting hormones, including Vaspsin that are associated with metabolic disorders.The aim of of the present study was to investigate the effect of 12 week resistance exercise on plasma levels of vaspin and blood pressure (BP) in hypertensive elderly women.

Methods: 30 hypertensive elderly women were randomly divided into two groups: the control and experimental groups. The training program, included resistance exercises, which were conducted increasingly for 12 weeks. Blood samples from all subjects after 12 weeks and were analyzed using t-test.

Results: After 12 weeks of resistance exercise, no significant differences in the serum levels of vaspin was seen in the experimental group (p=0.25),  but in the control group, significant Increase  in the serum levels vaspin was observed (p=0.03);  also, significant decreases were seen in both systolic (p=0.04) and diastolic BP (p=0.002 in the experimental group but in the control group, no significant changes were obtained in systolic BP (p=0.24) and diastolic BP (p=0.43), respectively.

Conclusion: 12 weeks of resistance exercise can prevent increasing trend of vaspin  serum levels and even reduce its levels Considering the reduction in systolic and diastolic BP following 12 weeks of resistance training, it can be indicated that the changes in BP are independent of changes is vaspin levels.