The Effect of an Eight Week Combined Exercise Training on  Oxidative Stress and Lipid Peroxidation in Postmenopausal  Women with Type 2 Diabetes

Azamian Jazi, A; Shokouhi, R

Volume 24, Issue 8 (Nov 2016) JSSU 2016, 24(8): 667-678 | Back to browse issues page

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Azamian Jazi A, Shokouhi R. The Effect of an Eight Week Combined Exercise Training on Oxidative Stress and Lipid Peroxidation in Postmenopausal Women with Type 2 Diabetes. JSSU 2016; 24 (8) :667-678
URL: http://jssu.ssu.ac.ir/article-1-3292-en.html

The Effect of an Eight Week Combined Exercise Training on Oxidative Stress and Lipid Peroxidation in Postmenopausal Women with Type 2 Diabetes

A Azamian Jazi ^*

, R Shokouhi

Abstract: (7839 Views)

Introduction: The basic levels of oxidative stress and lipid peroxidation is higher than normal in patients with type 2 diabetes. Therefore, due to the positive effects of exercise training (especially combined exercise training) on oxidative stress and lipid peroxidation in healthy people, the purpose of this study was to investigate the effect of an 8 week combined exercise training (Aerobic and Resistance) on oxidative stress and lipid peroxidation in postmenopausal women with type 2 diabetes.

Methods: In this semi-experimental study, 27 postmenopausal women with type 2 diabetes (age 55.30±4.1
years old, BMI 26.47±3.08 kg/m²) from Yazd city were purposefully selected and randomly divided into experimental (n=13) and control (n=14) groups. The experimental group participated in an eight week combined exercise training (three session per week), but during this period, the control group did not participate in any exercise training program. Superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), fasting blood sugar (FBS) and body fat percent were measured before and after the eight-week combined exercise training. Data were analyzed using paired and independent t-test. Statistical significance was set at P < 0.05.

Results: Serum SOD and CAT levels significantly increased (p = 0.000 and p = 0.001 respectively) and the MDA levels decreased (P = 0.036) in the experimental group after 8 weeks of combined exercise training. Also, FBS (P=0.000) and body fat percent (P=0.005) decreased in the experimental group compared with the control group.

Conclusions: It seems that oxidative stress and lipid peroxidation status in postmenopausal women with type 2 diabetes in the experimental group improve after eight weeks of combined exercise training, compared with the control group.

Keywords: Type 2 Diabetes, Combined Exercise Training, Superoxide Dismutase, Catalase, Malondialdehyde

Full-Text [PDF 694 kb] (2186 Downloads)

Type of Study: Original article | Subject: Exercise Physiology
Received: 2015/06/29 | Accepted: 2016/10/31 | Published: 2016/12/26

References

1. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison's Principles of Internal Medicine. 19 ed. USA: McGraw-Hill Education / Medical; 2015: 2404.

2. Yaghoubi AR, Khaki-Khatibi F, Zarghami N, Rahbani M. Evaluation of serum levels of MDA, Lipid Profiles and hs-CRP in Non-Diabetic, Non-Smoker patients suffering from CAD. Med J Tabriz Univ Med Sci 2012; 34(5): 87-92. [Persian].

3. Haghdoost AA, Rezazadeh-Kermani M, Sadghirad B, Baradaran HR. Prevalence of type 2 diabetes in the Islamic Republic of Iran: systematic review and metaanalysis. East Mediterr Health J 2009; 15(3): 591-9.

4. Aouacheri O, Saka S, Krim M, Messaadia A, Maidi I. The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus. Can J Diabetes 2015; 39(1): 44-9.

5. Saisho Y. Glycemic variability and oxidative stress: a link between diabetes and cardiovascular disease? Int J Mol Sci 2014; 15(10): 18381-406.

6. Nakanishi S, Suzuki G, Kusunoki Y, Yamane K, Egusa G, Kohno N. Increasing of oxidative stress from mitochondria in type 2 diabetic patients. Diabetes Metab Res Rev 2004; 20(5): 399-404.

7. Bogdanis GC, Stavrinou P, Fatouros IG, Philippou A, Chatzinikolaou A, Draganidis D, et al. Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans. Food Chem Toxicol 2013; 61: 171-7.

8. Maxwell SRJ, Thomson H, Sandler D, Leguan C, Baxlex AM, Thorpe GHG, et al. Poor glycemic control is associated with reduced serum free radical scavenging (antioxidant) activity in non-insulin-dependent diabetes mellitus. Ann Clin Biochem 1997; 34(6): 638-44.

9. Movahed MR. Diabetes as a risk factor for cardiac conduction defects: a review. Diab Obes Metab 2007; 9(3): 276-81.

11. Ceriello A. Oxidative stress and glycemic regulation. Metabolism 2000; 49(2): 27-9.

12. Maritim AC, Sanders RA, Watkins JB, 3rd. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol 2003; 17(1): 24-38.

13. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1990; 11(1): 81-128.

14. Gutteridge JMC. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 1995; 41(12): 1819–28.

15. Spirlandeli AL, Deminice R, Jordao AA. Plasma malondialdehyde as biomarker of lipid peroxidation: effects of acute exercise. Int J Sports Med 2014; 35(1): 14-8.

16. Wu B, Fukuo K, Suzuki K, Yoshino G, Kazumi T. Relationships of systemic oxidative stress to body fat distribution, adipokines and inflammatory markers in healthy middle-aged women. Endocr J 2009; 56(6): 773-82.

17. Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care 2005; 28(7): 1769-78.

18. Nojima H, Watanabe H, Yamane K, Kitahara Y, Sekikawa K, Yamamoto H, et al. Effect of aerobic exercise training on oxidative stress in patients with type 2 diabetes mellitus. Metabolism 2008; 57(2): 170-76.

19. Fisher-Wellman K, Bloomer RJ. Acute exercise and oxidative stress: a 30 year history. Dyn Med 2009; 8(1): 1.

20. Bloomer RJ, Fisher-Wellman KH. Blood oxidative stress biomarkers: influence of sex, exercise training status, and dietary intake. Gend Med 2008; 5(3): 218-28.

21. Elosua R, Molina L, Fito M, Arquer A, Sanchez-Quesada JL, Covas MI, et al. Response of oxidative stress biomarkers to a 16-week aerobic physical activity program, and to acute physical activity, in healthy young men and women. Atherosclerosis 2003; 167(2): 327-34.

22. Knez WL, Coombes JS, Jenkins DG. Ultra-endurance exercise and oxidative damage : implications for cardiovascular health. Sports Med 2006; 36(5): 429-41.

23. Bloomer RJ, Goldfarb AH. Anaerobic exercise and oxidative stress: a review. Can J Appl Physiol 2004; 29(3): 245-63.

24. Radak Z, Taylor AW, Ohno H, Goto S. Adaptation to exercise-induced oxidative stress: from muscle to brain. Exerc Immunol Rev 2001; 7: 90-107.

25. Metin G, Gumustas MK, Uslu E, Belce A, Kayserilioglu A. Effect of regular training on plasma thiols, malondialdehyde and carnitine concentrations in young soccer players. Chin J Physiol 2003; 46(1): 35-9.

26. Gomez-Cabrera MC, Domenech E, Viña J. Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radical Biology and Medicine 2008; 44(2): 126-31.

27. Vincent HK, Bourguignon CM, Vincent KR, Weltman AL, Bryant M, Taylor AG. Antioxidant supplementation lowers exercise-induced oxidative stress in young overweight adults. Obesity (Silver Spring) 2006; 14(12): 2224-35.

28. Azizbeigi K, Stannard SR, Atashak S, Mosalman-Haghighi M. Antioxidant enzymes and oxidative stress adaptation to exercise training: Comparison of endurance, resistance, and concurrent training in untrained males. J Exercise Sci Fitness 2014; 12(1): 1-6.

29. Bloomer RJ, Goldfarb AH, Wideman L, McKenzie MJ, Consitt LA. Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res 2005; 19(2): 276-85.

30. Jahani GR, Firoozrai M, Matin-Homaee H, Tarverdizadeh B, Azarbayjani MA, Movaseghi GR, et al. The Effect of Continuous and Regular Exercise on Erytrocyte Antioxidative Enzymes Activity and Stress Oxidative in Young Soccer Players. RJMS 2010; 17(74): 22-32. [Persian]

31. Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary. Diabetes Care 2010; 33(12): 2692-96.

32. Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S. Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetol 2010; 47(1): 15-22.

33. Snowling NJ, Hopkins WG. Effects of different modes of exercise training on glucose control and risk factors for complications in type 2 diabetic patients: a meta-analysis. Diabetes Care 2006; 29(11): 2518-27.

34. Hasanvand B, Karami K, Khodadadi A, Valipour M. Impact determination of strength and resistance training on Glycoside hemoglobin and blood sugar on patients with type II diabetes. Yafte 2011; 13(3): 75-81. [Persian]

35. Pescatello LS, Arena R, Riebe D, Thompson PD, (editors). ACSM’s Guidelines for Exercise Testing and Prescription. 9 ed. Philadelphia Wolters/ Kluwer—Lippincott Williams & Wilkins; 2014. P. 69-70, 80.

36. Oliveira C, Simoes M, Carvalho J, Ribeiro J. Combined exercise for people with type 2 diabetes mellitus: a systematic review. Diabetes Res Clin Pract 2012; 98(2): 187-98.

37. Yousefipour A, Taadibi V, Behpour N, Abdolhosein P, Delbari MA, Rashidi S. Association the effect of 8 aerobic and combined (aerobic and resistance) exercise on IL-6 plasma levels and insulin resistance in type 2 diabetic patient. JSSU 2013; 21(5): 619-31. [Persian]

38. Hermes-Lima M, Storey KB. Antioxidant defenses and metabolic depression in a pulmonate land snail. Am J Physiol 1995; 268(6): R1386-93.

39. Cohen G, Dembiec D, Marcus J. Measurement of catalase activity in tissue extracts. Anal Biochem 1970; 34(1): 30-8.

40. Uichiyma M, Mihara M. Determination of malondialdehyde precursor in tissues by thiobarbituric acid test. Analyt Biochem 1978; 86(1): 217-78.

41. Parker L, McGuckin T, Leicht A. Influence of exercise intensity on endogenous oxidative stress and antioxidant capacity. J Sci Med Sport 2012; 15(Supplement 1): 18-9.

42. Marius-Daniel R, Stelian S, Dragomir C. The effect of acute physical exercise on the antioxidant status of the skeletal and cardiac muscle in the Wistar rat. Romanian Biotechnol Lett 2010; 15(3): 56-61.

43. Teixeira de Lemos E, Pinto R, Oliveira J, Garrido P, Sereno J, Mascarenhas-Melo F, et al. Differential effects of acute (extenuating) and chronic (training) exercise on inflammation and oxidative stress status in an animal model of type 2 diabetes mellitus. Mediators Inflamm 2011; 2011: 253061.

44. Leelarungrayub D, Saidee K, Pothongsunun P, Pratanaphon S, YanKai A, Bloomer RJ. Six weeks of aerobic dance exercise improves blood oxidative stress status and increases interleukin-2 in previously sedentary women. J Bodyw Mov Ther 2011; 15(3): 355-62.

45. Salehi I, Mohammadi M, Farajnia S, Gaderi-Sophi F, Badalzadeh R, Vatankhah AM. Effect of Regular Swimming on Oxidative Stress and Atherogenic Index in Blood of Diabetic Male Rats. Sci J Hamdan Univ Med Sci 2007; 14(3): 29-35. [Persian]

46. Stoppa GR, Cesquini M, Roman EA, Ogo SH, Torsoni MA. Aminoguanidine prevented impairment of blood antioxidant system in insulin-dependent diabetic rats. Life Sci 2006; 78(12): 1352-61.

47. Chugh SN, Dhawan R, Kishore K, Sharma A, Chugh K. Glibenclamide vs gliclazide in reducing oxidative stress in patients of noninsulin dependent diabetes mellitus--a double blind randomized study. J Assoc Physicians India 2001; 49: 803-07.

48. Debnath T, Park SR, Kim da H, Jo JE, Lim BO. Anti-oxidant and anti-inflammatory activities of Inonotus obliquus and germinated brown rice extracts. Molecules 2013; 18(8): 9293-304.

49. Zhang N, Andresen BT, Zhang C. Inflammation and reactive oxygen species in cardiovascular disease. World J Cardiol 2010; 2(12): 408-10.

50. Karimi N, Roshan VD. Change in adiponectin and oxidative stress after modifiable lifestyle interventions in breast cancer cases. Asian Pac J Cancer Prev 2012; 14(5): 2845-50.