Introduction: Resistin, as a novel adipocytokine, is associated with type 2 diabetes. The present study aimed to determine the effect of circuit resistance exercise training on plasma resistin concentration and insulin resistance in type 2 diabetic men.

Methods: In this applied experimental study, 24 type 2 diabetic men were selected and randomly assigned into two exercise (n = 15, aged 46.40 ± 3.02 yrs) and control (n = 12, aged 45.06 ± 3.86 yrs) groups. Exercise training was performed in eight weeks, 3 days a week with intensity corresponding to 30-70% 1RM. Before and after exercise, levels of plasma resistin, insulin, blood glucose, HBA1c and HOMA-IR after a 12-h fasting were measured. Following the second blood sampling, data analysis was performed using T-test which, p Value <0.05 was considered significant.

Results: The study findings demonstrated a significant differnce between the exercise  and control groups (p&le0.05) in regard with plasma resistin (p&le0.002), insulin levels (p&le0.001), HOMA-IR (p&le0.001), fasting blood glucose (FBG) (p&le0.001) and HBA1c (p&le0.038).

Conclusion: It seems that circuit resistance exercise training can produce significant effects on  plasma resistin and insulin resistance in type 2 diabetic men. Moreover,  resistin level might be associated with insulin resistance in type 2 diabetic men.