Volume 24, Number 12 (Feb-Mar 2017) | JSSU 2017, 24(12): 972-980 | Back to browse issues page

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habib zade V, faghih N. Prevalence of Anti-Thyroid Peroxidase (TPO) Antibodies in Euthyroid Women with Unexplained Infertility Referred to IVF Center in Afzalipour Hospital in 2013-2014. JSSU. 2017; 24 (12) :972-980
URL: http://jssu.ssu.ac.ir/article-1-3163-en.html

Abstract:   (368 Views)

Introduction: Evidences suggest an association between the prevalence of thyroid peroxidase (anti-TPO) and infertility. About 5-10 percent of euthyroid women have anti-TPO antibodies.. The aim of this study was to obtain the prevalence of anti TPO antibodies in euthyroid women with unexplained infertility referred to IVF center in Afzalipour Hospital in 2013-2014.

Methods: Through convenience sampling 75 euthyroid women with unexplained infertility were selected for the experience group and 150 euthyroid fertile women with one successful pregnancy for the control group. Anti-TPO antibodies were measured and evaluated by Liaison method in serum of participant.

Results: Serum anti-TPO antibodies were significantly higher in infertile euthyroid women comparing to the healthy group (infertile group:15/4±3/61,fertile group:5/68±0/65 p=0/013). In the fertile group, serum anti-TPO antibody levels were significantly different between women with positive aborted history and the negative ones. There was no significant relation between age, BMI, TSH level and abuse of opium in two groups. There was also no significant relation between serum anti TPO antibody in one side and TSH level ,BMI and gravidity on other side  in each group. 

Conclusion: The results of our study show for the first time that serum anti-TPO antibodies were significantly higher in infertile euthyroid women comparing to healthy group. We put in that anti TPO antibody measured in infertile women.

Full-Text [PDF 562 kb]   (218 Downloads)    
Type of Study: Original article | Subject: Obstetrics
Received: 2015/04/4 | Accepted: 2015/11/1 | Published: 2017/04/26

2. Fritz M, Speroff L. Infertility in women In: Clinical gynecologic endocrinology and infertility (sperrof). 8 th ed Philadelphia Lippicott Williams & Wikins 2011.p. 564-624.
3. Putowski L, Darmochwal-Kolarz D, Rolinski J, Oleszczuk J, Jakowicki J. The immunological profile of infertile women after repeated IVF failure (Preliminary study). Eur J Obstet Gynecol Reprod Biol 2004; 112: 192-96.
4. Ramezani Tehrani F, Aghaee M, Asefzadeh S. The comparison of thyroid function tests in cord blood following cesarean section or vaginal delivery. International Journal of Endocrinology and Metabolism 2003; 1(1): 22-26.
5. Fauci A, Braunwald, Kasper D, Hauser E, Longo D, Jameson L. Thyroid disease In: Harrison’s principle Internal Medicine. 18th ed. New York Mc Graw Hill 2012. P .137-98.
6. Poppe K, Glinoer D, Tournaye H, Schiettecatte J, Devroey P, van Steirteghem A, et al. Impact of ovarian hyperstimulation on thyroid function in women with and without thyroid autoimmunity. J Clin Endocrinol Metab 2004; 89: 3808-12.
7. Davis LB, Lathi RB, Dahan MH. The effect of infertility medication on thyroid function in hypothyroid women who conceive. Thyroid 2007; 17(8): 773-77.
8. Thangaratinam S, Tan A, Knox E, Kilby MD, Franklyn J, Coomarasam A. Association between thyroid autoantibodies and misscarriage and preterm birth:meta-analysis of evidence. BMJ 2011; 9: 342: d 2616.
9. Negro R. Thyroid autoimmunity and pre-term delivery: brief review and meta-analysis. J Endocrinol Invest 2011; 34(2): 155-58.
10. Unuane D, Velkeniers B, Anckaert E, Schiettecatte J, Tournaye H, Haentjens P, et al. Thyroglobulin autoantibodies: is there any added value in the detection of thyroid autoimmunity in women consulting for fertility treatment? Thyroid 2013; 23(8): 1022-28.
11. Poppe K,Velkiners B,Glinoer D. The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab 2008; 4(7): 394-405.
12. Bellver J, Soares SR, Alvarez C, Muñoz E, Ramírez A, Rubio C, et al. The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion. Hum Reprod 2008; 23(2): 278-84.
13. Kilic S, Tasdemir N, Yilmaz N, Yuksel B, Gul A, Batioglu S. The effect ofanti-thyroid antibodies on endometrial volume, embryo grade and IVF outcome. Gynecol Endocrinol 2008; 24(11): 649-55.
14. Soltanghoraee H, Arefi S, Mohammadzadeh A, Taheri A, Zeraati H, Hashemi SB, et al. Thyroid autoantibodies in euthyroid women with recurrent abortion and infertility. IJRM 2010; 8(4): 153-56.
15. Twig G, Shina A, Amital H, Shoenfeld Y. Pathogenesis of infertility and recurrent pregnancy loss in thyroid autoimmunity. J Autoimmun 2012; 38(2-3): J275-81.
16. Ghoraishian SM, Hekmati Moghaddam SH, Afkhami-Ardekani M. Relationship between anti-thyroid peroxidase antibody and thyroid function test. Iran J Immunol 2006; 3(3): 146-49.
17. Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroiddisease: effects on obstetrical complications. J Clin Endocrinol Metab 2006; 91(7): 2587e91.
18. Chan S, Boelaert K. Optimal management of hypothyroidism, hypothyroxinaemia and euthyroid TPO antibody positivity preconception and in pregnancy. Clin Endocrinol (Oxf). 2015; 82(3): 313-26.
19. Walsh JP, Bremner AP, Bulsara MK, O'Leary P, Leedman PJ, Feddema P, et al. Parity and the risk of autoimmune thyroid disease: a community-based study. J Clin Endocrinol Metab 2005; 90(14): 5309-12.
20. Bulow Pedersen I, Laurberg P, Knudsen N, Jørgensen T, Perrild H, Ovesen L, et al. Lack of association between thyroid autoantibodies and parity in a population study argues against microchimerism as trigger of thyroid autoimmunity. Eur J Endocrinol 2006; 154(1): 39-45.
21. Sgarbi JA, Kasamatsu TS, Matsumura LK, Maciel RMB. Parity is not related to autoimmune thyroid disease in a population-based study of Japanese-Brazilians. Thyroid 2010; 20: 1151-56.
22. Friedrich N, Schwarz S, Thonack J, John U, Wallaschofski H, Volzke H. Association between parity and autoimmune thyroiditis in a general female population. Autoimmunity 2008; 41: 174-80.

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