Volume 24, Issue 1 (Apr 2016)                   JSSU 2016, 24(1): 93-101 | Back to browse issues page

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Ahmadi S, Mozaffari-Khosravi H, Dehghan-bonadaki S, Noori-majelan N, Lotfi M. The Effect of Oral L-Carnitine Supplementation on Lipid Profiles and Antioxidant Status in Hemodialysis Patients: A Randomized Clinical Trial. JSSU. 2016; 24 (1) :93-101
URL: http://jssu.ssu.ac.ir/article-1-3032-en.html
Abstract:   (5426 Views)

Introduction: Dyslipidemia and oxidative stress are commonly seen in the patients undergoing hemodialysis. This study aimed to evaluate the effect of oral L-carnitine supplementation on lipid profiles and total antioxidant capacity of the patients were treated with hemodialysis.

Methods: This study was a randomized, controlled clinical trial. The participants of this study consisted of 50 hemodialysis patients in dialysis centers of Yazd between 2013 and 2014. The patients randomly divided into two groups; L-carnitine (LG) and control group (CG). The patients in the LG were instructed to use daily 1g L-carnitine oral supplementation, as syrup for 12 weeks. The patients in the CG did not receive any supplement containing L-carnitine. At the baseline and the end of 12 weeks, triglycerides, total cholesterol (TC), LDLc, and total antioxidant capacity of serum (TAC) were evaluated in both groups.

Results: The mean of triglyceride and TC between and within groups were not significantly different. The mean of LDLc did not change in LG whereas a significant increase was seen in CG (p=0.02). The mean differences of LDLc between groups was statistically significant (p=0.05). No Significant changes were observed in serum levels of TAC in LG compared with CG (p=0.76). TAC was increased in both groups, but these changes were not statistically significant (p=0.62).

Conclusions: This study showed that oral supplementation of L-carnitine as syrup (1g per day) for 12 weeks among the hemodialysis patients would have no effect on