Volume 25, Issue 4 (July 2017)
JSSU 2017, 25(4): 311-321 |
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kaboli H, Haghighat S.
Evaluation of Borrago topical effects on wound healing of cutting wounds in mice
. JSSU 2017; 25 (4) :311-321
URL: http://jssu.ssu.ac.ir/article-1-2861-en.html
URL: http://jssu.ssu.ac.ir/article-1-2861-en.html
Abstract: (5547 Views)
Introduction: Borrago Officinalis has wide effects on rheumatoid arthritis, cardiovascular disorder, gastrointestinal diseases, pulmonary disorders and skin allergies. This plant can be useful in wound healing process due to specific compounds. The aim of this study was comparative evaluation of the effects of Borrago Officinalis with iodine and phenytoin on wound healing.
Methods: This is an experimental research study performed on 20 mature mice, in four therapeutic groups, including the Borrago Officinalis extract, iodine, phenytoin and control groups. Cutting wounds in dorsal part of mice body were evaluated through healing rate and histopathology at days 3, 7, 10 and 14. Data were analyzed using SPSS software using ANOVA and TUKEY tests.
Results: The findings about the mean area and the increase in the rate of wound healing in the use of Borrago Officinalis were compared at the 3rd, 7th, 10th and 14th days; the results indicated that the Borrago Officinalis had a positive effect on healing wounds (P˂ 0.05). However, this effect is more rather than both the iodine and control groups, but is less than the phenytoin group. . From the viewpoint of histopathology, the findings indicated a significant decrease in terms of inflammatory factors in Borrago Officinalis group (P= 0.007). The phenytoin group in relative to granulation tissue and epithelial cell growth had a higher level than the other of the groups.
Conclusion: The results show the positive effect of Borrago Officinalis extract on wound healing. In comparison, this effect is less than the phenytoin and more than iodine. More studies are needed on different doses of this plant and its comparative effect with other common treatments for wound healing.
Methods: This is an experimental research study performed on 20 mature mice, in four therapeutic groups, including the Borrago Officinalis extract, iodine, phenytoin and control groups. Cutting wounds in dorsal part of mice body were evaluated through healing rate and histopathology at days 3, 7, 10 and 14. Data were analyzed using SPSS software using ANOVA and TUKEY tests.
Results: The findings about the mean area and the increase in the rate of wound healing in the use of Borrago Officinalis were compared at the 3rd, 7th, 10th and 14th days; the results indicated that the Borrago Officinalis had a positive effect on healing wounds (P˂ 0.05). However, this effect is more rather than both the iodine and control groups, but is less than the phenytoin group. . From the viewpoint of histopathology, the findings indicated a significant decrease in terms of inflammatory factors in Borrago Officinalis group (P= 0.007). The phenytoin group in relative to granulation tissue and epithelial cell growth had a higher level than the other of the groups.
Conclusion: The results show the positive effect of Borrago Officinalis extract on wound healing. In comparison, this effect is less than the phenytoin and more than iodine. More studies are needed on different doses of this plant and its comparative effect with other common treatments for wound healing.
Type of Study: Original article |
Subject:
Pharmacology
Received: 2014/07/11 | Accepted: 2017/09/24 | Published: 2017/09/25
Received: 2014/07/11 | Accepted: 2017/09/24 | Published: 2017/09/25
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