Volume 21, Number 6 (Jan-Feb 2014)                   JSSU 2014, 21(6): 766-775 | Back to browse issues page


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Madani S, Shahbazi S, Mahdian R, Alizadeh J, Salehi Z. Investigating the Correlation between rs1049305 and ‏rs10244884 Polymorphisms of AQP-1 Gene and Menorrhagia ‎in Adolescents. JSSU. 2014; 21 (6) :766-775
URL: http://jssu.ssu.ac.ir/article-1-2450-en.html

Abstract:   (4255 Views)
Introduction: Aquaporins (AQPs) are water channels present in the cell wall, allowing water – ‎and occasionally other molecules – to pass the cell membrane. Their function is to maintain the ‎ internal milieu cells by regulating water and ion equilibrium. The endometrium undergoes ‎structural changes during the menstrual cycle. If implantation does not occur at the end of each ‎menstrual cycle, amplified endometrium is shed in absence of hormones and leads to ‎bleeding. Excessive uterine bleeding over 80 cc in each menstrual cycle called ‎menorrhagia, is a common gynecological disorder which causes large menstrual bleedings ‎and reduced quality of life for those affected.‎ Methods: The study included 37 patients with menorrhagia and 20 healthy ‎individuals. Genomic DNA was extracted from peripheral blood and Genotypes were determined ‎by ARMS-PCR and PCR-RFLP .Statistical analysis was performed using the SPSS ‎program. ‎ Results: Regarding ‏‎rs1049305, the C minor allele showed more frequency in patients' group‏ (0.47 vs. 0.37).‎‎ The results revealed that GG genotype presents less probable risk ‎for menorrhagia. ‎‎ rs10244884‎ also shows the same frequency. Conclusion: It can be concluded that both variants are important in pathogenesis of menorrhagia and the results confirm the important role of Aquqporin–1 channel in menstruation as well as endometrium physiology.
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Type of Study: Original article | Subject: Genetics
Received: 2013/06/15 | Accepted: 2013/12/7 | Published: 2014/02/5

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