Volume 21, Issue 2 (May-Jun 2013)                   JSSU 2013, 21(2): 189-197 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Farahani M. Antiviral Effect Assay of Thymus Kotschyanus and Nerium Oleander on HSV-1 in Vitro. JSSU. 2013; 21 (2) :189-197
URL: http://jssu.ssu.ac.ir/article-1-2426-en.html
Abstract:   (5896 Views)
Introduction: The treatment of HSV-1 diseases with the anti-herpes drugs often leads to the problem of viral resistance. There is a requirement for new efficient antiviral drugs. Medicinal plants with therapeutic application for different ailments in traditional medicine can be a useful way in this field. In the present study, Thymus kotschyanus and Nerium oleander with ethno-medical background were screened for antiviral property on HSV-1. Methods: The plants were extracted to obtain crude aqueous extract. These extracts were screened for their cytotoxicity against Hep II cell line by CPE (cytopathic effect( assay. Antiviral effect of the plant extracts were determined by cytopathic effect inhibition assay. Results: CC50 of Nerium oleander and Thymus kotschyanus extract was obtained with 4.73μg/ml and 9.28 ×102μg/ml respectively. Thymus kotschyanus extract inhibited HSV-1 multiplication at concentrations of 200-900μg/ml. Its EC50 and IC50 was 48.36 μg/ml and 1.12 ×102μg/ml. Conclusions: Thymus kotschyanus plant showed significant Antiviral effect on HSV-1, but Nerium oleander plant was toxic on it. Further research is required to find the mechanism of these plants’ effects in order to be used in conformation of anti-herpes drugs.
Full-Text [PDF 204 kb]   (1396 Downloads)    
Type of Study: Original article | Subject: Microbiology
Received: 2013/06/3 | Accepted: 2013/09/28 | Published: 2013/09/28

Add your comments about this article : Your username or Email:

© 2019 All Rights Reserved | SSU_Journals

Designed & Developed by : Yektaweb