Introduction: Vaginal dryness is a common symptom after menopause and reduction of estrogen levels. Prescription of the drug can temporarily be effective but it will not be possible for most of the women to take them for a prolonged period of time. Therefore, as an alternative to estrogen replacement, this study was conducted to determine the effect of vitamin D on vaginal dryness in menopause women. Methods: In the present double-blind clinical trial study, forty-four women were randomly divided into two groups. Treatment group received the vitamin D vaginal suppository, and the control group received placebo vaginal suppository in an 8-week period. The vaginal paleness and dryness were assessed in first, 2, 4 and 8 weeks of visit. The mean of maturation index of parabasal cells were measured in the beginning of the study as well as at the end of the eighth week. The Mann-whitney and independent T-test were utilized in order to analyze the data. Results: The mean of vaginal dryness in treatment and control groups were (Mean ± SD), 1.42±0.5, 2.09±0.76, respectively, at the end of eighth week (P<0.05). Mann Whitney test determined a significant difference (P<0.05) of vaginal palenss in the treatment group (1.9±0.62) compared to the control group (2.8±o.67). The mean of parabasal cells in the treatment group decreased significantly compare to the control group. Conclusion: Vitamin D vaginal suppository is effective on decrease of vaginal dryness and paleness in menopause women.

Keywords: Vitamin D, Menopause, Vaginal dryness, pale

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