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Introduction: In order to improve the oral health, systematic analysis of oral health condition and related factors should be conducted. This study aimed to evaluate dental caries and some related factors in 35-44 years old men & women in five urban areas of Sistan and Baluchestan in 2009-2010. Methods: In this descriptive cross-sectional study, 550 people were chosen by random stratified clustering in five different urban areas of the province. All participants were examined and the DMFT index was determined. Demographic and social information and their oral health behaviors were registered in a questionnaire which was composed of 11 questions. The data were analyzed by SPSS (version 17) and descriptive statistic methods. Results: Statistical analysis showed that average of DMFT was 10.05 ± 7.186. DMFT in females (11.43 ± 7.5) was more than males (8.68 ± 6.6) significantly (P< 0.001). A significant difference was found between ethnicity and DMFT (P< 0.05) while analysis did not reveal any difference between income, level of education, time and number of daily brushing. (P> 0.05) Conclusion: Results of this study could be used by public health managers to plan and evaluate public health in the future. With an emphasis on improving high risk patients’ situation, appropriate interventions can be designed to achieve good results in the short and long term

Keywords: Oral Health; Caries Dental; Socio- Economic Status

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