Introduction: The purpose of this study was to investigate the effects of a ten week period of aerobic exercise training on serum alkaline phosphates and osteocalsin in type 2 diabetic patients. Methods: In a quasi-experimental trial study twenty one male patients with type 2 diabetes(40-50 years) were randomly divided into exercise(n=11) and control(n=10) groups. The exercise group underwent a 10-week aerobic exercise program(three sessions per week, 45-60 minutes each session, at 50-65% of heart rate reserve). VO2max, BMI, fasting blood glucose and serum insulin, alkaline phosphatase and osteocalcin were measured at baseline and after exercise program. Results: Exercise program resulted in a significant increase in VO2max and a significant decrease in BMI, fasting blood glucose and HbA1c in exercise group however, no significant changes were found in the insulin concentration, alkaline phosphatase and osteocalcin. The bone formation markers and other measured variables did not show significant change in control group. Conclusion: These results suggest that aerobic exercise leads to glycemic improvement in type 2 diabetic patients, but does not affect serum levels of alkaline phosphatase and osteocalcin.

Keywords: Diabetes Mellitus Type 2; Exercise; Alkaline Phosphatase; Osteocalcin

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