Introduction: Drug addiction causes many complications for mother and fetus. Preterm labor, spontaneous abortion, intrauterine fetal growth retardation, prenatal mortality, placental abruption, preeclampsia, PROM, cesarean delivery and congenital anomalies among the newborns of addicted mothers are increased. The purpose of this study was to evaluate the final of maternal, fetal and neonatal of drugs addicted pregnant women. Methods: The study is a Cross-Sectional study was done on 236 pregnant women 19-40 years old addicted to drugs and 236 pregnant women non-addicted that referred for delivery to maternity hospitals of Imam Reza(as) and Imam Sajjad(as) during 2008-2010. Measuring instruments were: observing and checklist includes various sections were related on the aims. Data Analysis was done using SPSS. After ensuring that these values followed the normal distribution, chi-square test and Fisher exact test to compare qualitative variables of two groups and for quantitative variables T test was used. Confidence coefficient of 95% was considered. Results: The results showed complication such as placental abruption, preterm labor, preeclampsia, hypertension, PROM, cesarean, hepatitis B, meconium in the amniotic fluid, intrauterine fetal growth retardation, anomalies in infant, low Apgar score in the first and fifth minutes, fetal death, hypoglycemia, neonatal convulsions, breathing problems, RDS, need to neonatal resuscitation, admission in NICU, neonatal death in the first three days of birth, weight loss, low circumference head size among infants were born of mothers addicted compared with the control group had shown significant increase. Conclusion: Opium addiction causes serious complications for mother, fetus and newborn.

Keywords: Pregnancy; Embryonic and Fetal Development; Infant, Newborn; Mothers; Substance-Related Disorders; Embryo, Mammalian

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